PubMed Health⌕ Search

Biomedical subjects

E Süss

Publications and source records attributed to E Süss.

At least 19 recordsLinked to original sources
PubMed1989

Comparative antimicrobial activity of the new macrolides against Borrelia burgdorferi.

The in vitro and in vivo activity of the new macrolides azithromycin, clarithromycin and roxythromycin was compared with that of erythromycin against Borrelia burgdorferi. In in vitro tests using ten clinical isolates all macrolides were highly active against Borrelia burgdorferi (MIC90 0.015-0.06 micrograms/ml). Azithromycin was more potent than the other macrolides in experimental animal infection, eradicating the organism in all animals tested at a dosage of 8 mg/kg.

4-Quinolones↗
PubMed1989

[Allergic reactions of the immediate and delayed type following prednisolone medication].

Allergic sensitization due to corticosteroids seldom occur and are compound-specific, as a rule. They induce various clinical features, in particular urticaria, different exanthematous reactions and contact dermatitis as shown by our observations in 10 patients with prednisolone-allergy. In three cases a simultaneous allergy due to methylprednisolone was found. Impairment of the features or alterations in the clinical morphology after the application of prednisolone suggest the diagnosis, which can be confirmed by means of the scratch and epicutaneous testing and in one patient by the oral exposure, additionally. In addition a delayed-type sensitization to propylene glycol could be proved in three cases, and the same was with romulgin and parabens in one case each. Dexamethasone was used and tolerated as alternative and emergency medication in equivalent doses.

Administration, Oral↗
PubMed1987

In vitro and in vivo susceptibility of Borrelia burgdorferi.

The antispirochetal activity in vitro and in vivo of several antibiotics against ten isolates of Borrelia burgdorferi from human spinal fluids and skin biopsies was determined. Borrelia burgdorferi was most susceptible in vitro to erythromycin, ceftriaxone and cefotaxime (MIC90: 0.06, 0.06, 0.12 mcg/ml respectively). Less activity was observed with tetracycline, amoxycillin and lincomycin (MIC90: 0.50 mcg/ml), imipenem and augmentin (MIC90: 0.25 mcg/ml), oxacillin (MIC90: 1 mcg/ml), ciprofloxacin (MIC90: 2 mcg/ml) and ofloxacin (MIC90: 4 mcg/ml). Penicillin G, normally regarded as appropriate treatment for Lyme disease, had an MIC90 of only 4 mcg/ml. With the exception of erythromycin, activity in vitro corresponded to the activity in vivo. Erythromycin, however, was less active in vivo, and penicillin G showed poor activity both in vitro and in vivo.

Animals↗
PubMed1985

The TINA test.

Explore the source record for details and available documents.

Adjuvants, Immunologic↗
PubMed1980

[Methodical problems in detecting new allergens in ;animal experiments (author's transl)].

With the help of the Tina-test partial aspects of the predictive testing of potential allergens were examined in animal experiments. The Tina-test is based on the intramuscular, intracutaneous and epicutaneous application of the allergen in question using Freund's adjuvant and sodium laurylsulphate. The test has been acknowledged by the authorities as a standardized method. the following aspects were examined. A prolongation of the exposition times causes an increase of the sensitization rates. Freund's adjuvant should be used in every case, since the percentage of sensitized animals may be clearly increased. Outbred guinea pigs are well suited. the use of inbred animals is not necessary. In cases where more than 30% of the experimental group fall ill during the procedure of sensitization, the results are not reliable. Neither the sex of the animals nor the seasons influence sensitization rates. Per experimental group at least 25 animals should be used. Pilot studies with different quantities of allergens (potassium bichromate: 131 mg: 13.1 mg and 1.31 mg) did not show a clear influence on the results. Similar results we received also with nickel-2-sulphate. The sensitization rate corresponded well with our clinical experience in 19 out of 24 substances. With turpentine, nickel, mercury and a low-molecular phenol resin the number of the sensitized animals was somewhat too low, whereas with tetramethylthiuramdisulfide the percentage was somewhat too high.

Allergens↗