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Biomedical subjects

E Sadovsky

Publications and source records attributed to E Sadovsky.

At least 73 records · Page 4Linked to original sources

Antepartum fetal evaluation by assessment of fetal heart rate and fetal movements.

Three antenatal monitoring tests--fetal movement acceleration test (FMAC-test), fetal heart rate-nonstress test (FHR-NST), and daily fetal movement recording (DFMR) were evaluated in 212 high risk pregnant women. While in 196 cases all three tests were normal, in 16 patients one to three tests showed pathological results. In the latter group, there was a significantly higher incidence of perinatal mortality, low Apgar score and growth retardation. Since false positives are known to occur in these tests, at least two should be pathological to warrant delivery in am attempt to prevent fetal death in utero. The sequence in which the pathology appears in the deteriorating fetus is as follows: the first to become non-reactive is the FMAC-test, followed by decreased fetal movements till cessation, and, finally, severe changes in the FHR-NST take place. The importance of this sequence of events is discussed.

Delivery, Obstetric↗

Thromboplastic activity of amniotic fluid in term and postmature gestations.

The danger to the newborn inherent in a postmature pregnancy has gained recognition. However, the diagnosis of postmaturity remains a difficult problem. The thromboplastic activity of amniotic fluid (TAAF) increases with the gestational age. Based on this phenomenon, the TAAF of 45 women in the 41st to 43rd weeks of gestation was established, using their amniotic fluid as a source of thromboplastin. It was found that in all cases in which the TAAF value was less than 42 seconds, the newborns exhibited clinical evidence of postmaturity.

Amniotic Fluid↗

Diurnal variation of fetal activity.

Fetal movements (FM) in utero are an expression of fetal well-being, and the importance of assessing these movements has been shown in cases of chronic fetal distress. The diurnal variations were studied in 2 groups of high-risk pregnant women who assessed FM by subjective perception. The patients in the first group assessed FM before and after meals. The majority (86%) reported no significant difference in fetal activity before and after meals; the remaining 14% noted a constant decrease after meals. Of the second group, which assessed FM 3 times daily 82% discerned no significant differences and 18% showed significant diurnal variations. It is concluded that assessment of FM is not necessarily dependent on a strict timetable.

Circadian Rhythm↗

The incidence of different types of fetal movements during pregnancy.

In high risk pregnancies with severe fetal distress, a reduction of fetal movements may take place before fetal death occurs. This decrease is accompanied by a weakening of the fetal movements. One hundred and twenty pregnant women (310 recordings) between 20 and 41 weeks gestation recorded fetal movements and classified them into weak, strong, and rolling. The movements noted by the woman were correlated to those recorded by a fetal movements recorder. The rate of weak movements gradually decreased until the 36 to 37th week, while the strong and rolling movements increased. From the 36 to 37th week till term weak movements increased again with a decline in strong and rolling movements. Before fetal death, or in severe fetal distress with decreased total movements, the relative rate of weak movements increased. Reduction in daily total movements without a change in the distribution of the type of movement may not indicate fetal distress.

Adult↗

The role of fetal movements assessment in cases of severe RH immunized patients.

Two cases of severe Rh-immunization are presented. The obstetric history, maternal serum anti-D titre, amniotic fluid spectrophotometric evaluation, amniography and ultrasound placentography suggest the diagnosis of hydrops fetalis. The reduction of fetal movements until cessation in the presence of an audible fetal heart point to a severely distressed fetus and impending death, thus providing additional data confirming the diagnosis of hydrops fetalis. The importance of diagnosed hydrops fetalis lies in the fact that most authors agree that in these cases treatment of the fetus should not be attempted.

Adult↗

The effect of intrauterine devices containing zinc and copper on their levels in serum.

Serum levels of copper and zinc were determined in 11 health women in whom Latex Leaf intrauterine devices (IUDs) containing copper and zinc had been inserted. Patients with low levels of serum copper or zinc before insertion usually had increased levels of either of these metals while using the device, but they did not exceed the upper limits of normal values. When the group was considered as a whole, the serum levels of zinc showed a slight tendency to increase with duration of IUD use, whereas there was no statistical difference between the serum levels of copper before and after insertion of the IUD.

Adult↗

Preliminary report on the use of the combined multiload contraceptive intrauterine device (ML Cu-250).

The multiload contraceptive intrauterine device (IUD) (ML Cu-250) is made of polyethylene and contains copper wire which is wrapped around the stem, providing 250 sq mm of exposed copper surface area. The IUD was inserted in 294 women comprising 1884 women-months of use. Four pregnancies and three expulsions occurred. In 13 instances the ML Cu-250 IUD was removed for medical reasons (side effects). The net cumulative pregnancy rate for a 12-month period after insertion was 3.9% and the expulsion rate was 1.6%; the medical removal rate was 8.2%. No perforations or tubal pregnancies occurred. Our results with the ML Cu-250 was compared with our previous experience with other IUDs. It seems that the comparatively low pregnancy, expulsion, and medical removal rates render the ML Cu-250 a good device for clinical use.

Adult↗

Decreased fetal movements and polyhydramnios.

It was previously demonstrated that in high-risk pregnancies, pronounced reduction of fetal movements until cessation, with audible fetal heart sounds, indicates severe fetal distress and impending death. Immediate delivery is indicated provided the fetus is viable. Three instances of cessation of fetal movements associated with polyhydramnios are reported; the fetuses proved to have malformations lethal for the newborn infant. These cases of polyhydramnios with diminished fetal movements stress the importance of investigating fetal morphology in this condition. Antenatal diagnosis of congenital anomalies may influence decisions about intervening in cases of decreased fetal movements.

Abnormalities, Multiple↗

Experience with the Ypsilon (Soichet) intrauterine device.

The Ypsilon intrauterine device (IUD), which consists of stainless steel covered with silicone rubber, was studied in 209 women. In the 3,169 woman-months of use, there were 21 pregnancies, nine expulsions, and in 24 instances the Ypsilon IUD was removed for medical reasons (side effects). The net cumulative pregnancy rate in the 12 months after insertion was 6.4% and the expulsion rate was 3.8%; the medical removal rate was 9.0%. No perforations or tubal pregnancies occurred. The comparatively low medical removal rate renders the Ypsilon IUD a fairly good device for clinical use, although the pregnancy rate is rather high.

Adult↗

Fetal movements recorder, use and indications.

A new device for recording fetal movements is presented. This device is composed of 2 sensors, incorporating a highly sensitive piezoelectric material. It is sensitive to rapid straining forces such as fetal movements and relatively insensitive to steady, slow movements such as uterine contractions and maternal respiratory movements. In this study of 20 women, the sensors were placed on 2 different zones of the abdomen, usually above the umbilicus. There was a good correlation between fetal movements recorded by the device and those felt by the patients. Seventy percent of all observed fetal movements recorded by the device were registered simultaneously by the women. The device recorded 90.4 percent and the women recorded 79.7 percent of all such movements.

Female↗

Correlation between thromboplastic activity and lecithin/sphingomyelin ratio in amniotic fluid preliminary report.

THe thromboplastic activity of amniotic fluid was correlated with the lecithin sphingomyelin (L/S) ratio in 59 pregnancies. It was shown that the thromboplastic activity and the L/S ratio in amniotic fluid had a coefficient of correlation of r = --0-73 (P less than 0-004). The thromboplastic activity was estimated by a modified method for prothrombin time, and a time of 113 seconds appeared to correspond to an L/S ratio of 2, in that it was the border line between maturity and immaturity of the fetal lungs. Thirty women were delivered within 24 hours of a sample of amniotic fluid being obtained. In the three patients whose babies developed the respiratory distress syndrome, the thromboplastic activity was estimated as being slower than 113 seconds.

Amniotic Fluid↗