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Biomedical subjects

E Sadovsky

Publications and source records attributed to E Sadovsky.

At least 109 records · Page 6Linked to original sources
PubMed1975

A syndrome of recurrent intrauterine adhesions.

Traumatic intrauterine adhesions are known to be reversible. In some cases, following lysis of adhesions we find residual adhesions on hysterography. We have studied 11 cases in whom new adhesion formation, of different type and location have recurred following curettage for lysis of adhesions or in subsequent pregnancy. In each case there were between two and five different forms of intrauterine adhesions during the course of study. In all 11 cases hypomenorrhea was a prominent symptom. On premestrual curettage a scanty amount of endometrium was removed. Their obstetric history was characterized by sterility (four cases) and repeated early abortions, spontaneous or missed. Treatment consisted of repeated curettage and placement of an IUD. Four patients who subsequently become pregnant carried pregnancy to term or near term. Intrauterine adhesions may be considered as a localized manifestation of more generalized process of endometrial fibrosis. This may explain this syndrome of recurrent intrauterine adhesions and the paradoxical phenomenon of limited adhesions being associated with amenorrhea and hypomenorrhea.

Abortion, Spontaneous↗
PubMed1975

Successive spontaneous abortions with diverse chromosomal aberrations in human translocation heterozygote.

A patient who had 3 first-trimester spontaneous abortions (blighted ova) was found to be carrying a balanced 13/14 Robertsonian translocation. In the 2 cases cytogenetically analyzed, different chromosomal aberration were found (trisomy 16 and supernumerary D elements). Histologic examination of the placentas of all 3 abortions revealed hypovascular or avascular villi, hydropic degeneration, and occasional atypical stromal (Hofbauer-like) cells. In 2 cases the decidua was examined by light microscopy and was diffusely inflamed with a plasmolymphocytic infiltrate. The relation of the maternal translocation to the repeated abortions with chromosome anomalies is discussed.

Abnormalities, Multiple↗
PubMed1975

Prevention of postpartum venous thrombosis with low doses of heparin.

Postpartum superficial and deep venous thrombosis were found in 22.3% and 5.3% of women with varicose veins who delivered vaginally, or by cesarean section. The preventive use of low doses of heparin (5,000 U every 12 h injected subcutaneously) in 116 parturients with varicose veins reduced significantly the incidence of postpartum venous thrombosis. None of the 26 women with previous thrombosis who received preventive treatment, developed such an event.

Dose-Response Relationship, Drug↗
PubMed1975

Retrograde seeding of endometrium: a sequela of tubal flushing.

The problem of retrograde seeding of endometrial tissue fragments to the peritoneum was investigated by injecting fluids through the cervical canal into the uterus before and after curettage. Fluid samples were collected from the peritoneal cavity through a laparoscope. Endometrial glands were detected in almost all of the fluids samples, and seeding was greater after curettage than before. It is concluded that any procedure in which fluids are pushed through the uterus may cause peritoneal seeding of endometrium.

Dilatation and Curettage↗
PubMed1975

Leukocyte alkaline phosphatase in the newborn.

Leukocyte alkaline phosphatase (LAP) activity was studied in 50 women at delivery and in the newborn after delivery. The following findings were observed: (1) the LAP activity of newborns is lower than that of the mothers; (2) significant decrease in the LAP activity has been observed in newborns on the 4th day after delivery; (3) there are no significant differences between newborns from normal and prolonged labor; (4) immediately after delivery the LAP scores of male newborns are lower than those of females, but 4 days later these scores were reversed, and (5) 4 days after delivery, the LAP scores do correlate to the weight of the newborn.

Alkaline Phosphatase↗
PubMed1975

Leukocyte alkaline phosphatase in newborn infants after delivery and in the puerperium.

Leukocyte alkaline phosphatase (LAP) activity increases progressively during pregnancy, returning to non-pregnant levels 6 weeks post-partum. This enzymatic activity is under the influence of placental steroid hormones, thus reflecting placental function. LAP activity is thus a reflection of the dynamic relations between estrogenic, progestational and corticoid activity during pregnancy. LAP activity was studied in 60 women and in their 61 newborn infants at delivery and during the first five days of the puerperium. The Kaplow cytochemical technique was employed. The average maternal LAP score as well as the average newborn infant LAP score was considerably higher than the LAP score of the normal adult. The level of the enzyme in the maternal granulocytes was significantly higher than that of the newborn (Tab. I). During the first five days after labor, there was progressive decrease in the LAP score in the maternal and the newborn blood; on the fifth day the LAP scores of both were only slightly above the normal adult score (Figs. 1, 2). An inverse relation between the LAP score and the birth weight of the infant was found (Tab. III). These results confirm the view that LAP activity in the fetus in utero, are dependent on placental steroid function. The lower LAP values in the newborn, as compared to those of the mother are probably dependent on the lower newborn hormone levels. The significance of the relation between LAP scores and the infants birth weight is not clear.

Alkaline Phosphatase↗