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Biomedical subjects

E Sagredo

Publications and source records attributed to E Sagredo.

At least 19 recordsLinked to original sources
PubMed1990

[Evaluation of the gingival status by quantification of the T6 (CD1a) and HLA-DR antigens].

The number/mm2 of sections of Langerhans cells (LC's) expressing antigens T6 and/or HLA-DR was determined in eight human gingival samples which consisting of normal gingivae, contraceptive induced hyperplastic, traumatic, inflammatory and diphenylhydantoin hyperplasic gingivae. All samples, except those from normal gingivae, showed inflammatory and/or hyperplasic histopathological patterns. In the immunostained samples, LC's appeared in variable numbers and were randomly distributed between the keratinocytes. All pathological samples, except the inflammatory gingiva showed HLA-DR+ keratinocytes. Wilcoxon and Mann-Whitney statistical tests suggested the existence of three subpopulations of LC's: T6+/DR+; T6-/DR+ and T6+/DR-. The subpopulation T6+/DR+ was predominant in conditions of normal immune response. The subpopulation T6-/DR+ suggested the presence of newly incorporated LC's from the lamina propia. T6+/DR- subpopulations could indicate the existence of a system to avoid overstimulation. It is concluded that quantitative evaluation of T6 and HLA-DR expression was representative of the gingival conditions and the disease activity.

Adult↗
PubMed1990

Changes in the number and distribution of Langerhans cells in the hydantoin hyperplasic gingiva as compared with the clinically normal one.

A study was made of the number of Langerhan's cells (LCs) per mm2 of section which express the antigens T6 and/or HLA-DR in seriated gingival sections of diphenylhydantoine-induced hyperplasia (HG) and clinically normal gingivae (NG). NG showed histological correlation with its macroscopic appearance. In HG the classical histopathological findings were verified, as well as the epithelial maturation irregularities, conductive to the development of epithelial gaps. In the immunostained samples, LCs appear amply distributed in the epithelium in greater numbers than in NG and more branched except in the immature areas, where they mostly express HLA-DR. In HG keratinocytes, HLA-DR+ are observed in the basal layer, except in developing epithelial gap zones. The Wilcoxon test for the NG-T6/NG-DR and HG-T6/HG-DR was not significant; but the Mann Whitney test for NG-T6/HG-T6 and NG-DR/HG-DR was significant to p less than 0.05. It is understood that the increase in LC numbers in HG is a manifestation of their active participation in local immune reactions. The presence of DR+/T6- LCs in the less keratinized areas seems to indicate the relationship of LCs with epithelial proliferation and/or differentiation.

Adult↗
PubMed1989

[Benign fibrohistiocytoma of the soft palate].

A case of benign fibrohistiocytoma of the soft palate in a 61 years-old woman is presented and current approaches to histogenesis of fibro-histiocytic tumors commented.

Denture, Complete, Upper↗
PubMed1985

[Optical study of the sensitive hair (vibrissae) of the Wistar rat using imbedding in plastic resin and staining in paraffin with the usual technics].

Mystical vibrissae of wistar rat processed in TAAB-Transmit resin R and stained with standard methods are studied from a morphological point of view. Vibrassae show up as hair follicles plunged in a blood sinus encircled by a thick connective capsule. Nerve fibers entered this connective capsule. Anatomical, embryological, functional and staining characteristics are discussed.

Animals↗