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Biomedical subjects

E Sajo

Publications and source records attributed to E Sajo.

5 recordsLinked to original sources

Spatial distribution of indoor aerosol deposition under accidental release conditions.

Indoor aerosol dispersion and particle deposition was investigated using a series of puff releases of nonspecific activatable tracers simulating an accidental source. Initial particle size distribution included the respirable range, with most of the particles between 0.5 to 5.0 microm. Tracers were released in a nuclear laboratory/work environment and were collected via passive collector foils to obtain the spatial distribution of deposition. The observed distribution characteristics did not always correspond to the measured air flow patterns, and they showed a non-negligible dependence on aerosol dynamics such as thermophoretic effects. The collected data represent integrated deposition flux, which can serve for validation of aerosol dynamics models that aim to predict the deposition fluence of particles and may also be used for planning surface contamination surveys following accidental releases.

Accidents, Occupational↗

Deterministic calculations of photon spectra for clinical accelerator targets.

A method is proposed to compute photon energy spectra produced in clinical electron accelerator targets, based on the deterministic solution of the Boltzmann equation for coupled electron-photon transport in one-dimensional (1-D) slab geometry. It is shown that the deterministic method gives similar results as Monte Carlo calculations over the angular range of interest for therapy applications. Relative energy spectra computed by deterministic and 3-D Monte Carlo methods, respectively, are compared for several realistic target materials and different electron beams, and are found to give similar photon energy distributions and mean energies. The deterministic calculations typically require 1-2 mins of execution time on a Sun Workstation, compared to 2-36 h for the Monte Carlo runs.

Computers↗

A historically controlled trial of tyrosine for cocaine dependence.

Cocaine dependence continues to be a major public health problem and efforts to develop pharmacotherapies have been disappointing. Chronic cocaine use is believed to cause catecholamine depletion and similarities exist between cocaine withdrawal and major depression. Tyrosine is the dietary precursor to catecholamines and has yielded positive results in small trials of its antidepressant efficacy. Tyrosine 2 g every 8 hours was administered on an open-label basis to 49 cocaine-dependent individuals, as an adjunct to intensive out-patient drug abuse counseling. Retention in treatment at 90 days was compared to data from a control group of 80 subjects who had received 10 mg of imipramine per day in an earlier trial. Median retention was 17 days in both groups. No side effects were reported by the subjects receiving tyrosine. These results do not support the utility of tyrosine in the treatment of cocaine dependence.

Adolescent↗

Marijuana.

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Humans↗