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Biomedical subjects

E Sakamoto

Publications and source records attributed to E Sakamoto.

At least 19 recordsLinked to original sources
PubMed1995

Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite.

Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1 x 10(-5) M DTMA.

Administration, Oral↗
PubMed1990

[Reconstruction of occlusal function with osseointegrated implant following mandibular resection].

We succeeded satisfactorily to restore the occlusal function by use of an osseointegrated implant following iliac bone grafting and partial mandibulectomy in 4 patients who underwent surgical resection of odontgenic cyst and benign or malignant tumor of the oral cavity. Case 1: The patient was a 19-year-old man. Partial resection of the mandible was carried out under the diagnosis of odontgenic keratocyst of the left lateral incisor to the 1st premolar region. Iliac bone grafting was performed as secondary surgery. After confirmation of the fusion of the grafted bone, the occlusal function was restored by use of an osseointegrated implant. Case 2: The patient was a 36-year-old man. After segmental resection of the mandible under the diagnosis of ameloblastoma of the left 2nd premolar to the right 2nd premolar region, mandibular reconstruction was carried out with an A-O plate. Iliac bone grafting was performed as secondary surgery. After fusion of the grafted bone had been confirmed, the A-O plate was remounted and the fixture was immediately implanted. Five months later, vestibuloplasty by free skin grafting and attachment of the abutment were carried out. A superstructure was mounted. Case 3: The patient was a 22-year-old woman. The histopathologically confirmed odontogenic myxoma in the right mandible posteriorly from the second premolar was resected. Immediate reconstruction of the mandible was carried out by use of an iliac bone graft. After confirmation of the fusion of the grafted bone, the occlusal function was restored by use of an osseointegrated implant. Case 4: The patient was a 57-year-old woman with carcinoma of the right lingual margin and mouth floor. The tumor was resected with the mandibular margin. Immediate reconstruction of the tongue and mouth floor with a major pectoral muscle skin flap was carried out. In the absence of evidence of recurrence, restoration of the occlusal function was attempted with an osseointegrated implant.

Adult↗
PubMed1989

[CT findings of malignant lymphoma of the anterior mediastinum--differentiation from invasive thymoma].

CT findings were compared retrospectively between 9 cases with malignant lymphoma of the anterior mediastinum and 8 cases with invasive thymoma. CT findings of malignant lymphoma were as follows: 1) The majority of the tumors were bilateral and extended beyond the anterior mediastinum to the other mediastinum compartments. 2) Their margin was either smooth or lobulated. 3) Their density was either homogeneous or heterogeneous. In the case with heterogeneous density, ring, triangle and/or band-like low density areas, just like interspace of fused lymph nodes, were demonstrated. Calcification or cysts could not be shown. 4) Patent inherent vessels without deviation were occasionally demonstrated running through the tumors. 5) The tumors faced and contacted widely to anterior chest wall and often pressed the lung laterally at the anterior parietomediastinal pleural reflection. 6) Pleural implants were not demonstrated.

Adolescent↗
PubMed1989

Determination of vitamin B6 derivatives in foods and biological materials by reversed-phase HPLC.

Through use of a simplified analyzing system, seven vitamin B6 derivatives were determined with a satisfactory sensitivity and precision. This system consisted of a single reversed-phase ODS column with a fluorescence detector employing an isocratic solvent system. Each vitamin B6 derivative in some foods and biological materials was determined, based on the measurement of the integrated peak area. The data obtained by this method were compared with those obtained from a bioassay by Saccharomyces uvarum ATCC 9080, after acid hydrolysis of these materials.

Animals↗
PubMed1989

[Biomechanical study on the mechanism of the mandibular condylar fracture. 1].

The condylar process is one of the sites predisposed to fracture clinical and experimental studies on the fracture mechanism have so far been undertaken by a number of our predecessor. However, the difference in the fracture mechanisms of intracapsular and extracapsular fracture has not completely been determined yet. In a Japanese Journal of Oral and Maxillofacial Surgery: Vol.32, 1362-1381, 1986: Shimada have previously reported the strong possibility that the direction and extend of fracture lines in the fracture of condylar process were influenced by the morphological characteristics of the condylar head. In order to verify this postulation, stress distribution patterns by the cross-sectional morphology of various types of condylar heads were investigated by two-dimensional finite element method, using 15 Indian edentulous mandibles. In this analysis, loading was applied to three directions in the model of the mandibular body, and two directions in the model of the mandibular head. The results indicated the following something. 1) With the loading in the direction of condylar head from mandibular angle, compressed stress arose on the condylar head with the surface. And with the loading in the direction of condylar head from chin and mandibular body, tugged stress arose on the condylar neck. 2) With the loading in the direction of vertical, these were conjectured that comminuted fracture arose on convex type, sagittal fracture arose on concave type and a style midway fracture arose on straight type. 3) With the loading in the direction of lateral, these were conjectured that fracture of condylar neck arose on the three types, especially the tendency was remarkable on straight type.

Biomechanical Phenomena↗
PubMed1989

[Measurement of oral and facial blood flow with a laser Doppler flowmeter. 4. Alteration of oral blood flow by position change].

The laser doppler flowmeter was developed by Stern in 1975 and applied for practical use by Nilsson et al. in 1980. Since then, it has been used in various fields of medicine. The primary advantages of this device an that it is noninvasive and can monitor the blood flow continuously and rapidly. We used a Laser doppler flowmeter to continuously monitor the change in the oral peripheral blood flow due to changes in the body position of patients in a dental chair, since such changes are unavoidable during the course of dental treatment. A change from the sitting position to the supine position caused an increase in oral blood flow in 19 of 20 patients. In terms of the mean value per minute, oral blood flow was 23% greater in the supine position.

Blood Flow Velocity↗
PubMed1989

[Mechanical study on the stability of multiform mini-plates. I. Double-T-type plate (90, regular, 6-holes) in mandibular body fracture].

In this present paper, we reported the stability of osteosynthesis using a special type of mini-plate for mandibular fractures as evaluated from a mechanical study with static loading. The materials used in this study were fifteen bars made of acrylic resin, each divided at the center of its length into two parts to simulate a condition of mandibular body fracture. Following the fixation of these materials with mini-plates firmly attached between their cut ends, the bars were secured in a vice at one end and a static load was applied from the vertical direction at the other end. The amount of displacement of the loaded end was investigated with a displacement-measuring device, and the strains on mini-plates and test bars were measured with strain gauges. A comparative study was conducted on three kinds of mini-plates: 1) Group S, fixed with one Champy mini-plate, 2) Group W, fixed with two Champy mini plates, 3) Group T, fixed with one double-T-type mini-plate. The following results were obtained: 1) The amount of displacement was largest in the vertical direction and smallest in the horizontal direction in the three groups. Especially in group T, it was smaller the longitudinal and horizontal axes than in the other two groups. 2) Longitudinal strain of the plate was smallest in group W. However, the strain on the test bar was smallest group S. Especially , in group T, the largest compressive strain was observed at the lower portion of the synthesized ends.(ABSTRACT TRUNCATED AT 250 WORDS)

Bone Plates↗
PubMed1989

[Plastic operation of alveolar process by visor osteotomy].

Extraction of teeth from the lower jaw often results in atrophy of the alveolar process and mandibular body, and sometimes the atrophy progresses so severely as to seriously affect the fitness of the denture, especially the full denture. If the alveolar ridge is markedly resorbed, patients are not satisfied, unless the alveolar process is surgically heightened and the fitness of the denture is regained. Plastic operation of the alveolar process by visor osteotomy and grafting of the iliac bone was performed on a 54-year-old woman who presented at our Department with a complaint of unfitness of the full denture because of marked atrophy of the mandibular alveolar process. As a result of this operation, a functionally well-fitting denture could be fitted to the satisfaction of this patient. This paper describes the outline of the surgical procedure.

Alveolar Ridge Augmentation↗
PubMed1989

[An analysis of 30 patients with renal trauma: diagnostic value of radiographic examinations].

To evaluate the diagnostic value of radiographic examinations in renal trauma, 30 patients treated between April, 1985 and March, 1988 were examined. The 25 male and 5 female patients ranged in age from 10 to 74 years, with 17 (57%) less than 30 years of age. Causes of injuries were traffic accidents in 19 patients (63%), falls in 5 (17%), sports in 2 (7%), and others in 4 (13%). Twenty-nine patients (97%) had hematuria and 3 (10%) had shock due to renal injury. The presence of shock indicated severe renal injury, but the degree of hematuria did not correlate to severity of injury. Of the 30 patients, 18 (60%) had renal contusions, 7 (23%) had minor lacerations, 4 (13%) had major lacerations and one had vascular injury. One patient had penetrating trauma and the other 29 had blunt trauma. Two patients (7%) had pre-existing renal anomalies. Associated injuries were present in 16 patients (53%). The presence of associated injuries had no relation to the severity of the renal injury. Computerized tomography (CT) with contrast medium was more sensitive to abnormal findings, especially subcapsular and perirenal hematoma, than excretory pyelography. Findings of renal angiography provided additional anatomical information for deciding immediate surgical treatment and for selecting operative methods for salvage of the kidney.(ABSTRACT TRUNCATED AT 250 WORDS)

Accidents↗