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Biomedical subjects

E Sakmar

Publications and source records attributed to E Sakmar.

At least 37 records · Page 2Linked to original sources
PubMed1977

High-pressure liquid chromatographic (HPLC) determination of tolmetin and its major metabolite in plasma.

A high-pressure liquid chromatographic assay was developed for the quantitative determination of tolmetin and its major metabolite in plasma. Determination of tolmetin was compared to a previously reported spectro-photometric assay method. The standard curves were evaluated statistically and daily standard curves were preferred over a pooled standard curve. The method was applied to samples of one subject's plasma containing both tolmetin and its major metabolite.

Chromatography, High Pressure Liquid↗
PubMed1977

Linear and nonlinear assessment of tolmetin pharmacokinetics.

Plasma concentration-time data in man after oral dosing of the nonsteroidal antiinflammatory agent, tolmetin sodium, were fitted to both linear and nonlinear pharmacokinetic equations. The apparent elimination half-life of tolmetin is shown to be 4.5 to 6.0 hours. An analytical method is presented which allows measurement of plasma concentrations for at least 32 hr (compared with a previous limit of about 8 hr) after a single oral dose of the equivalent of 400 mg of tolmetin acid.

Adult↗
PubMed1976

Blood ethanol concentrations during and following constant-rate intravenous infusion of alcohol.

Blood ethanol concentrations were determined in 7 subjects during and subsequent to a 2-hr constant-rate intravenous infusion of ethyl alcohol (8% v/v). Eight to 10 capillary blood samples were collected during the infusion and 10 to 21 samples were obtained after the infusion ceased. Thus, the total time course of blood ethanol concentrations in man was defined, both during and postinfusion. Blood ethanol concentration data from each of 6 subjects were fitted simultaneously to the two equations for the one-compartment open model with zero order input and Michaelis-Menten elimination kinetics. The average Vm[0.232 mg/(ml x hr)] and Km[0.0821 mg/ml] obtained fron these fittings correspond very closely with corresponding values estimated by the fitting of all the mean concentration-time data obtained following oral administration of 4 different doses of ethanol to 8 other fasting subjects in another study. A disproportionate increase in area under the concentration-time curve with increase in dose (gm/kg) was observed in a single subject who was infused with equal volumes of a 4% and an 8% (v/v) ethanol solution at the same constant rate.

Adult↗
PubMed1976

Food effects on absorption and metabolism of alcohol.

The concomitant ingestion of various foods with alcohol resulted in a decreased area under the blood alcohol concentration curve, a lower peak concentration and an increased time to reach peak. Michaelis-Menten kinetics indicated a decreased alcohol metabolism rate after the ingestion of carbohydrates or fats.

Absorption↗
PubMed1975

In vitro and in vivo availability of commercial prednisone tablets.

A three-way crossover bioavailability study was performed using nine adult male volunteers with three different commercial prednisone tablets. Plasma samples were assayed for prednisolone, the active metabolite of prednisone, by a radioimmunoassay method. Statistical analysis showed significant differences in the rate of appearance of prednisolone in plasma but not in the amount converted to prednisolone. The results suggest that differences in in vivo rates of appearance of prednisolone in plasma correlate with in vitro rates of dissolution.

Adult↗
PubMedDate not supplied

Comparative bioavailability study of two tablet formulations of cimetidine.

A two-way crossover bioavailability study of two commercial cimetidine formulations was performed on 24 healthy male volunteers. Drug was administered after an overnight fast and plasma samples were withdrawn periodically for 12 h. Urine was collected throughout the study period. Results indicated that the two formulations were bioequivalent since no statistically significant difference in means was detected for any of the parameters studied. Extensive interpatient variation in cimetidine blood concentration was observed during both treatments.

Administration, Oral↗