Biogenic amines and narcotic effects. II. Serotonin turnover in the rat after acute and chronic morphine administration.
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Animals↗
Biomedical subjects
E Sanders-Bush
Publications and source records attributed to E Sanders-Bush.
p-Chloroamphetamine--inhibition of cerebral tryptophan hydroxylase.
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Amphetamine↗
Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following 9 -tetrahydrocannabinol.
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Analgesia↗
Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in brain.
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Amphetamine↗
Increased serotonin turnover in the acutely morphine treated rat.
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Animals↗
p-Chloramphetamine--species differences in the rate of disappearance and the lowering of cerebral serotonin.
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Amphetamine↗
Tryptophan hydroxylase activity in developing rat brain.
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5-Hydroxytryptophan↗
Effect of drugs on amines in the CNS.
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Amines↗
p-Chloroamphetamine. Temporal relationship between psychomotor stimulation and metabolism of brain norepinephrine.
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Amphetamine↗
P-chloroamphetamine: in vivo investigations on the mechanism of action of the selective depletion of cerebral serotonin.
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5-Hydroxytryptophan↗
Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions.
In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are not due to a selective cytotoxic action on B-9 cells; and that a lateral 5HT pathway, possibly from the B-9 cell group, projects to the metathalamus-thalamus.
Amphetamines↗
p-Chloroamphetamine: evidence against a serotonin mediated learning deficit in PKU.
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Aging↗
Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis.
Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic administration of antagonists elicits a paradoxical downregulation of both receptors. This article explores the possible explanations for these anomalous findings.
Adaptation, Physiological↗