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Biomedical subjects

E Sauer

Publications and source records attributed to E Sauer.

47 records · Page 3Linked to original sources

[Clinical and experimental investigations with 201tl for noninvasive myocardial scintigraphy (author's transl)].

The biological distribution of 201Tl after intravenous injection was studied experimentally in 42 rats. It was found (see figure 1) that the kidneys showed the greatest affinity for 201Th, reaching an activity concentration of 6.6% per gramme of tissue, almost independently of time. Within the first 30 minutes of injection, myocardial activity exceeds that of the surrounding structures (10 min. p.i.: 4.24%/g; 30 min. p.i.: 2.58%/g). During this time the myocardium can be well demonstrated by "image processing". The relatively fast myocardial kinetics of 201Tl (half value time 33 minutes) make it necessary, strictly speaking, to use a scintillation camera. The clinical value of this method is illustrated by a number of case histories.

Animals↗

[Results of non-specific iliac crest biopsy in patients with bronchial carcinoma (author's transl)].

Systematic bone marrow examinations in patients with bronchial carcinoma (n equals 75) gave positive findings (identification of tumor cells) in 12% related to all types of tumors and in 32% of microcellular carcinoma. The information value of this method is relatively small with regard to the assessment of operability, because positive findings in stages I and II are extremely rare. Non-specific iliac crest biopsy provides therapeutically and prognostically important pointers in patients who are to be irradiated (tumor stage III and all microcellular tumors of stages I-III), because a positive bone marrow finding must be valued as stage IV.

Adult↗

[Acute bilateral pulmonary infiltration as a complication of cytostatic treatment (author's transl)].

In three patients on cytostatic drugs acute bilaterally symmetrical pulmonary infiltrates developed. Bacterial, viral or mycotic infections were excluded. The histological findings in the lungs of two had died were those of nonspecific alveolitis. Clinical and radiological findings, as well as the rapid regression of the infiltrates after stopping the cytostatic drugs in the third patient and the marked similarity of the X-ray picture to some similar cases reported in the literature, suggest that these infiltrates resulted from an acute allergic reaction to the cytostatic drugs.

Acute Disease↗

Disseminated melanomatosis of the central nervous system and other organs: a case report.

This case represents an example of clinically occult, disseminated neoplastic disease with almost asymptomatic but severe involvement of the central nervous system. The only helpful diagnostic investigation appeared to be cerebrospinal fluid cytology. Extensive post mortem examination was inconclusive as to whether the widespread CNS involvement with melanoma was primary or secondary.

Brain↗