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Biomedical subjects

E Schmied

Publications and source records attributed to E Schmied.

17 recordsLinked to original sources
PubMed1993

[Alarm signs in drug-induced skin reactions].

Drug-induced skin reactions may represent warning signs in three different situations. First, the cutaneous rash may reveal an underlying systemic disease being perhaps still undiagnosed. The following examples illustrate this concept: the drug-induced eruption observed in patients suffering from infectious mononucleosis, from lymphoproliferative malignancy or from HIV infection. Second, the cutaneous rash may indicate a drug-induced multisystemic disease possibly more severe than the cutaneous symptoms. Third, the cutaneous rash may herald the most severe drug-induced skin reaction, Lyell syndrome, due to epidermal necrolysis probably of immunological origin.

Diagnosis, Differential↗
PubMed1992

Systemic corticosteroids do not prevent postherpetic neuralgia.

We review the use of corticosteroids in preventing postherpetic neuralgia (PHN) in a retrospective study over 5 years and 10 months. Out of 113 patients evaluable, 46 (40%) had PHN. 21 of these 46 patients (38%) had received prednisone (p = 0.49; n.s.). Duration and intensity of PHN were not different in the prednisone-treated group. This long-term study does not support the use of prednisone for preventing PHN.

Female↗
PubMed1991

L-tryptophan-induced eosinophilia-myalgia syndrome. I. Report of two cases with pseudoxanthoma-elasticum-like skin changes.

Two female patients who fulfilled the criteria for L-tryptophan-induced eosinophilia-myalgia syndrome (EMS) had, together with morphea-like and fasciitis-like sclerotic changes of the skin, lesions that clinically mimicked pseudoxanthoma elasticum (PXE). Histology was compatible with the diagnosis; electron microscopy did not reveal calcium deposits. PXE-like changes may represent an additional feature of the pleomorphic L-tryptophan-induced EMS.

Eosinophilia-Myalgia Syndrome↗
PubMed1990

[Cutaneous manifestations of infection due to hepatitis B virus].

Two entities can precede the clinical and biological signs of hepatitis B virus (HBV) infection: the various lesions of the serum sickness-like prodrome (urticaria, maculopapular exanthem, purpura, etc.) induced by the deposition of intravascular circulating immune complexes and papular acrodermatitis of childhood in which the physiopathological role of HBV has not yet been established. The persistence of HBs antigen (HBs Ag) may give rise to the purpuric lesions of essential mixed cryoglobulinemia and to the livedo, the nodules and ulcerations of poly-arteritis nodosa.

Acrodermatitis↗
PubMed1990

[Cutaneous manifestations of tuberculosis].

Tuberculous lesions of the skin occur rarely nowadays. We therefore have mostly lost the knowledge to recognize this entity. Furthermore, the great variability of the clinical and particularly dermatologic manifestations of the disease can tax the most astute clinician. The challenge is even greater, when the patient has an intercurrent condition such as a malignancy or AIDS. In order to make understanding easier, we replace all descriptive terms, some carried over from the last century, by a useful pathogenetic and clinical, algorithmic classification. Finally the necessity of biopsy and specific cultures for proper diagnosis and treatment of any skin lesion consistent with skin tuberculosis is emphasized.

Antitubercular Agents↗
PubMed1990

[Pasteurellosis in human pathology].

Pasteurella are common bacteria among healthy animals. Humans usually are infected by dog and cat bites or scratches. Besides, local skin infection, Pasteurella may spread, in some cases, to lungs, joints, bones or, less frequently, to other organs.

Aged↗
PubMed1990

[Hoigné's syndrome or pseudo-anaphylactic reaction to procaine penicillin G: a still current classic].

In this journal in 1959 R. Hoigné described the first cases of pseudo-anaphylactic reactions induced by intramuscular administration of procaine penicillin G. This complication, characterized by acute psychological and neurological manifestations, is still of current interest since recently three cases of Hoigné's syndrome were diagnosed at the University Hospital of Geneva. This entity deserves consideration because it must be differentiated from authentic anaphylactic shock due to penicillin. The distinction is important from a therapeutic viewpoint since Hoigné's syndrome allows continuation of treatment, whereas it is absolutely contraindicated in anaphylactic shock.

Adult↗
PubMed1990

A patient with features of both Bardet-Biedl and Alström syndromes.

We describe a 30-year-old patient with acanthosis nigricans, diabetes mellitus with insulin resistance, hypogonadotropic hypogonadism, pigmentary degeneration of the retina and cerebellar, pyramidal and posterior columnar involvement. He had normal mental function, normal hearing and no hexadactyly. The patient had symptoms of both Bardet-Biedl and Alström syndromes, but did not manifest all the main features of either syndrome. This suggests either that the Bardet-Biedl, Alström, Laurence-Moon syndromes (including the variant described by Edwards) have a highly variable expression or that our case is a new variant within this group of syndromes.

Acanthosis Nigricans↗
PubMed1990

Age-related rather than ulcer-related impairment of venous function tests in patients with venous ulceration.

Various noninvasive tests of venous function and skin oxygenation were studied in 12 patients with unilateral venous ulcer and in 24 control subjects. In the ulcer patients, there was no difference between the leg with and the leg without ulcer regarding all the tests studied. Except for the maximal venous outflow, the patients and their age- and sex-matched controls did not differ with regard to all parameters studied. In contrast to these findings, ageing was associated with a reduction in maximum venous outflow, a shortening in venous filling time, an increase in venous pressure in the posterior tibial vein and a diminution of transcutaneous partial oxygen pressure.

Age Factors↗
PubMed1989

[Leg ulcer complicated by secondary amyloidosis].

A 76-year-old woman with a chronic leg ulcer for the last thirty-seven years was hospitalized in our institution for chronic diarrhea and terminal kidney failure with proteinuria. The diagnosis of secondary amyloidosis due to persistent skin inflammation was confirmed by aspiration of subcutaneous abdominal fat and by kidney biopsy which showed AA type systemic amyloidosis. This appears to be a rare complication of chronic leg ulcers as there have been only eight publications covering eleven cases in the literature.

Aged↗
PubMed1989

Bullous pemphigoid and multiple sclerosis: more than a coincidence? Report of three cases.

In three patients with long-standing multiple sclerosis, bullous pemphigoid developed. The diagnosis of bullous pemphigoid was based on histologic findings, direct and indirect immunofluorescence, and Western blots showing IgG reacting with the 220 to 240 kD bullous pemphigoid antigen in the serum of three patients. Contrary to previous observations, bullous pemphigoid associated with multiple sclerosis was not different from bullous pemphigoid alone. Three similar cases have been reported previously, so the occurrence of bullous pemphigoid in patients with multiple sclerosis may be more than a coincidence.

Aged↗
PubMed1980

Living with cost containment.

Cost containment need not have an adverse effect on quality of care. A critical review of policies and practices can reveal possibilities for controlling and containing costs while maintaining or even increasing quality. The author discusses several areas that deserve the attention of nursing administrators and staff.

Cost Control↗