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E Schoen

Publications and source records attributed to E Schoen.

8 recordsLinked to original sources

[Evaluation of radiologic criteria in rheumatoid arthritis].

The authors compared the hand Xrays of 53 patients with rheumatoid arthritis (AR) with those of 53 control subjects matched for age and s. x. Each AR patient conformed to the New York clinical criteria. Assesment was carried out on Xrays of both hands, search being made for erosions, geodes, and joint narrowing, the severity being graduated from 0 to 4, according to data from the international Atlas of Radiology. The sensitivity, sepcificity and severity of each of these abnormalities was studied joint by joint (18 for the hand). Analysis of the results shows that study of all 18 joints in the hand is not useful; account may be taken only of the first three metacarpo-phalangeal joints, the carpo-metacarpal joints and the radio-carpal joint. The proximal interphalangeal joints, contrary to the most commonly held opinion, are more a source of errors than of diagnosis. Erosion is the most specific sign, especially if one is only considering the characteristic sites. With a specificity of the order of 98 per cent, this abnormality has sufficient weight to counteract the very low incidence of the disease in a population in comparison with degenerative disorders. Geodes should be studied more by their severity than by their frequency; this is high in the controls, which diminishes their specificity (45 for the wrist, 62 for the first carpo-metacarpal, and 75 for the first metacarpo-phalangeal joint). Joint narrowing is a difficult sign to read and its value is all at the radiocarpal and carpal joints.

Arthritis, Rheumatoid↗

The Protein Crystallization Facility (PCF) for EURECA.

Research on the structure of molecules by X-ray diffraction analysis requires large single crystals. However, the dynamic behavior of proteins caused by their high molecular weight prevents the growth of large single crystals if this process is disturbed by thermal convection. For example, protein single crystals grown under terrestrial (1 g) conditions are limited to dimensions in the order of 0.1 mm, whereas the size of crystals, grown under (quasi) space conditions has been 5 times larger (pilot experiment CRYOSTAT, Spacelab). Under EURECA conditions (e.g. no microgravity disturbances), the result in regularity of crystal growth and size is expected to be much better. In this paper an overview is given of the protein crystallization facility which includes Experiment-, Service- and Secondary Cooling Module, and its interfaces to the EURECA Carrier. At the end, there will be presented a short mission profile concerning cooling-, power- and data exchange requirements.

Convection↗