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E Seem

Publications and source records attributed to E Seem.

28 records · Page 2Linked to original sources
PubMed1990

Transcapillary filtration in lower limbs with deep venous thrombosis; the role of the capillary filtration coefficient.

The capillary filtration coefficient (CFC) of the Starling equation was measured with strain gauge plethysmography at calf level of lower limbs with deep venous thrombosis (DVT). CFC was significantly elevated in limbs with DVT compared to the contralateral limb (0.0037(0.0005) ml min-1 100 g-1 mmHg-1 rise in filtration pressure and 0.0026(0.0010) ml min-1 100 g-1 mmHg-1 rise in filtration pressure, p less than 0.01) (Mean(SD]. Calf blood flow was also measured with strain-gauge plethysmography and was significantly increased in limbs with DVT compared to the contralateral (2.9(1.4)ml min-1 100 g-1 and 2.3(1.4) ml min-1 100 g-1, p less than 0.05). Increased venous pressure (Pv) found in lower limbs with DVT could be expected to lead to reduced blood flow. Our results point to an inflammatory reaction over-ruling increased venous resistance. No correlation was found between CFC and blood flow but this may have methodological explanations since increased Pv will influence both CFC and blood flow recordings obtained with plethysmography. Interstitial fluid hydrostatic pressure (Pif) measured with the 'wick-in-needle' technique in the deep posterior muscle compartment was significantly increased compared to the contralateral limb (6.3(3.5) mmHg and -1.2(3.4) mmHg, p less than 0.001). No correlation was found between CFC and Pif. Increase in CFC and blood flow at calf level is probably important in oedema in lower limbs with DVT.

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PubMed1987

Arterial blood flow in deep venous thrombosis of the lower limbs.

Calf blood flow was measured in 19 patients with deep venous thrombosis (DVT) of the lower limb using a mercury strain gauge. The affected limb had a significantly (P less than 0.05) higher blood flow (2.9 +/- 1.4 ml/min. 100 g of tissue) then the contralateral limb (2.3 +/- 1.2 ml/min. 100 g). Blood flow velocity in the common femoral artery measured with a pulsed Doppler ultrasound flowmeter in 13 patients was also significantly (P less than 0.05) higher in the limb with DVT (6.6 +/- 2.8 cm/s) compared to the contralateral limb (5.3 +/- 3.0 cm/s). Interstitial fluid hydrostatic pressure (Pif) was measured by the "wick-in-needle" technique in the deep posterior compartment of the leg. There was a significant (P less than 0.001) increase in the limb with DVT (6.3 +/- 5.5 mmHg) compared to the contralateral limb (1.2 +/- 3.4 mmHg).

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PubMed1986

Transcapillary forces in subcutaneous tissue of lower limbs with deep venous thrombosis.

Starling forces (interstitial fluid pressure, plasma- and interstitial fluid colloid osmotic pressures) were measured in the subcutaneous tissue of legs in 22 patients with deep venous thrombosis (DVT). For comparison, measurements were obtained in the contralateral leg and in healthy controls as well. Interstitial fluid pressure (Pif) was measured with the 'wick-in-needle' technique and we found a significantly higher pressure in limbs with DVT compared to contralateral limbs and controls. Interstitial fluid was collected from subcutaneous tissue with the 'wick technique'. Colloid osmotic pressure was measured in wick interstitial fluid (COPif) and plasma (COPpl) with an osmometer. A significant reduction of COPif was found in limbs with DVT compared to the contralateral side and controls. The COPpl was also significantly reduced in patients compared to controls. Saphenous vein pressure (Pv) measured at the ankle was significantly increased in the thrombosed limb compared to the contralateral. We conclude that the main cause of subcutaneous oedema in DVT of the lower limbs is increased transcapillary filtration caused by a rise in Pv. This leads to a fall in COPif and rise in Pif which act as oedema-preventing mechanisms.

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PubMed1984

Treatment of Raynaud's phenomenon with ketanserin in patients with connective tissue disorders.

The serotonin receptor blocker ketanserin was given orally in a double blind crossover study to 10 patients with connective tissue disorders and Raynaud's phenomenon. Eight of the 10 patients improved clinically on ketanserin and none on placebo. Digital blood flow was assessed with laser Doppler flowmetry (LDF), photoplethysmography, and skin temperature measurements. Laser Doppler flowmetry was the most useful method, showing a significant reduction in recovery time after a standard cold provocation. Although the resting flow was not significantly improved, digital ulcers healed in four out of five patients, providing evidence of increased nutritive flow. The results of this study suggest that orally administered ketanserin may be an effective and well tolerated treatment for Raynaud's phenomenon associated with connective tissue disorders, especially scleroderma.

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PubMed1975

Salicylate saturation index in neonatal jaundice.

30 serum samples from premature and newborn infants with non-haemolytic hyperbilirubinaemia were analyzed to prove the accuracy of determination of albumin binding capacity for bilirubin. The salicylate method of Odell was used to determine the saturation index of albumin indicated by a decrease in optical density through displaced bilirubin. Bilirubin is stoichometrically displaced from albumin by the addition of salicylate. The values of the sautration index correspond to free binding sites. Analysis of our data demonstrated that there is no direct correlation between the saturation index (SI) and total serum bilirubin/albumin concentration quotient. Methodical errors, problems in statistics and other theoretical concepts are discussed. The salicylate method is not suitable for accurate determination of albumin binding capacity for bilirubin.

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PubMedDate not supplied

Computed tomography in deep venous thrombosis with limb oedema.

Computed tomography was used in 12 patients to investigate the distribution of oedema in the soft tissue compartments of lower limbs with deep venous thrombosis. Oedema was evenly distributed throughout the subcutis and the muscular compartments in tomograms obtained 25 cm proximal to the ankle. Significantly less swelling in the muscular compartments was found 10 cm proximal to the ankle. Interstitial fluid hydrostatic pressure was measured in the subcutis, and in anterior and posterior muscular compartments, and was significantly increased in all cases. Except for one case, the recorded pressures were well below 30 mmHg, which is considered the limit above which compartment syndromes occur. Tissue compliance was significantly lower in muscular compartments than in the subcutis.

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