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Biomedical subjects

E Seidel

Publications and source records attributed to E Seidel.

At least 19 recordsLinked to original sources
PubMed2001

Endocrine alteration in the adrenal gland in kidney transplant patients.

INTRODUCTION: Endocrine alterations associated with chronic renal failure have been reviewed recently. Some of these alterations are of clinical relevance. The aim of this study was to investigate the effect of renal transplantation on the endocrine system of the adrenal gland of the transplant recipients. METHODS: The serum angiotensin-converting enzyme (SACE), plasma renin (PR) and plasma aldosterone (PA) were examined in 30 patients before and after renal allotransplantation. Additionally measured parameters were blood pressure, serum creatinine, potassium, sodium, the duration of dialysis and immunosuppressive medication. RESULTS: Six weeks after renal transplantation, serum creatinine decreased from 820.07 +/- 172.01 to 138.12 +/- 67.54 micromol/l. In the same period, serum potassium decreased from 5.42 +/- 0.89 to 4.17 +/- 0.42 mmol/l. PA and PR decreased from 1,150.84 +/- 976.06 to 233.52 +/- 217.07 micromol/l, and from 121.07 +/- 100.12 to 26.16 +/- 10.86 microU/ml, respectively. SACE decreased from 0.21 +/- 0.21 to 0.13 +/- 0.11 micromol/l. No significant correlation was seen with blood pressure, serum sodium, the duration of dialysis and immunosuppressive drugs. Additionally, 2 patients with acute renal graft dysfunction showed significant increases in PR and PA. After successful treatment both levels declined very quickly to prerejection levels. Patients after binephrectomy show no elevation in PR (5-47 microU/ml) or PA (21-416 micromol/l) neither before nor after renal transplantation. CONCLUSIONS: We conclude that renal transplantation has profound effects on the recipient's renin-angiotensin-aldosterone system. Because of the rapid depression after renal transplantation, it does not appear to be involved in the pathogenesis of post transplantation hypertension but may reflect a role for repair processes after renal allotransplantation.

Adrenal Gland Diseases↗
PubMed1999

Reference values for vertebral artery flow volume by duplex sonography in young and elderly adults.

BACKGROUND AND PURPOSE: Vertebrobasilar ischemia has been attributed to a reduction of net vertebral artery flow volume, the product of mean flow velocity and the cross-sectional area of the vessel. It can be determined by duplex sonography. There are no reference values for vertebral artery flow volume in an age group representative of patients with cerebrovascular disease. METHODS: We examined 50 nonvascular neurological patients (age 55.8+/-14.0 years). Flow velocities and vessel diameters were recorded in the intertransverse (V2) segments bilaterally, and the flow volume was calculated according to the following equations: (1) Q1=time-averaged mean velocity times area and (2) Q2=(time-averaged maximum velocity/2)times area. RESULTS: Flow velocities and vessel diameters tended to be lower on the right side, resulting in a lower flow volume. Flow volumes (according to Equation 1) were 77.2+/-29.8 mL/min on the right side, 105.3+/-46.4 mL/min on the left side, and 182.0+/-56.0 mL/min net. Side-to-side differences were not significant. Flow volumes calculated with the 2 equations did not differ significantly. An age dependence could not be shown, but vessel diameters and net vertebral artery flow volumes were significantly lower in women than in men. The normal range for net vertebral artery flow volume defined by the 5th to 95th percentiles is between 102.4 and 301.0 mL/min. This wide range is due to the high interindividual variability of the parameters. CONCLUSIONS: On the basis of the reference values presented here, the association of decreased vertebral artery flow volume and vertebrobasilar ischemia should be reevaluated. Additional areas for investigation include the quantification of collateral flow in the vertebral arteries in carotid artery occlusive disease and their contribution to overall cerebral blood flow volume.

Adult↗
PubMed1998

Assessment of rehabilitation needs in cancer patients.

In Germany and the United States cancer patients are admitted to rehabilitation programmes after anti-cancer treatment. Such programmes do not exist in the Netherlands. This leads to the question of whether in the Dutch health care situation certain problems (impairments-disabilities-handicaps) exist in (ex)cancer patients that can be dealt with by a rehabilitation programme. Using theories on the development of health care needs of chronic patients and the WHO approach of Impairment, Disability and Handicap, a framework for a questionnaire was developed. This questionnaire used quality of life items, functional health items and items mainly from specific cancer-orientated instruments. One hundred and forty seven patients participated in the study. After the results of this phase were clear, a focus group approach combined with in-depth interviews was used to present patients with possible rehabilitation programmes. Questions were formulated verifying the nature of prior results, inquiring about specific elements and desired outcomes and about practical aspects concerning post-cancer rehabilitation. The population consisted mostly of breast cancer (69.4%) and bowel cancer patients (23.8%). Quality of life scored averagely moderate, not indicating large problems. About 26% of all respondents wanted to receive professional help; this was largely determined by perceived quality of life and level of social support. The desire for professional help concentrated significantly on role performance, cognition, control, family relations, psychologic and somatic aspects. The focus group discussion and interviews revealed that patients would prefer a rehabilitation programme focusing on reducing fatigue, reinforcing loadability, coping with social aspects, dietary aspects and finding new life targets. Quality of life seemed to be relatively high and only 26% of post-cancer patients indicated the need of rehabilitation. Related to a significantly lower quality of life score, improved physical loadability and psychosocial functioning (coping) should be the main outcomes of such a programme. Specific elements such as dietary advice and finding new life targets should, from the patients' perspective, be included.

Adult↗