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Biomedical subjects

E Shand

Publications and source records attributed to E Shand.

2 recordsLinked to original sources
PubMed1982

The effects of dimercaptosuccinic acid and other chelating agents on the retention of platinum in the rat kidney after treatment with cisplatin.

The ability of three chelating agents, dimercaptopropanesulphonate (DMPS), dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DPTA), to reduce the retention of platinum in the kidneys was tested in male Sprague-Dawley rats treated 24 h previously with Cisplatin. DMPS and DMSA, when given as four daily doses of 1 mMol/kg, increased the urinary excretion from 10.1% +/- 1.2% to 13.6% +/- 1.3% and 13.5% +/- 2.6%, respectively, but only DMSA caused a small but significant reduction in the kidney platinum content. DTPA was totally ineffective. It is concluded that none of these agents is likely to be useful for the reduction of Cisplatin-induced renal toxicity in the clinical situation.

Animals↗
PubMed1979

Amyloid in basal cell carcinomas.

Stromal or intratumour deposits of amyloid were found in thirty of forty-six randomly selected basal cell carcinomas. Amyloid was found less often in histologically aggressive tumours than in other sub-types. Immunoglobulins, predominantly IgM, were demonstrated in all but one of these thirty cases, corresponding to the distribution of the amyloid deposits. Electron microscopy revealed 'early' amyloid in one case which showed numerous stromal IgM bodies on immunofluorescence but no evidence of amyloid by routine histochemical methods.

Amyloid↗