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Biomedical subjects

E Shanon

Publications and source records attributed to E Shanon.

At least 19 recordsLinked to original sources

Multifocal extraosseous eosinophilic granuloma of the head and neck.

Multifocal eosinophilic granuloma (Hand-Schüller-Christian disease) confined to soft tissues in the head and neck region is described in a man, 32 years of age. The lesions were detected at varying time intervals within a period of 14 months. They were located in the gingivae, the submaxillary salivary glands, the thyroid gland, and in the dermal lining of the external auditory meatus. Clinical, histologic, ultrastructural, and immunohistochemical findings are presented and discussed. Some of these findings go along with the tenet that the typical proliferating histiocyte in eosinophilic granuloma is a pathologic Langerhans' cell, or a close kindred to it.

Adult

Adenocarcinoma of the epiglottis. Report of a case and review of the literature.

The larynx is rarely the site of an adenocarcinoma. About 60 patients were described in the literature, and the epiglottis was primarily involved in only three. We studied a fourth case in a 77-year-old man. Adenocarcinoma of the larynx is a highly lethal neoplasm that tends to spread to both regional lymph nodes and distant sites. Despite radical surgical measures, the cure rate is low.

Adenocarcinoma

Parotid gland hemorrhage as a complication of coumarin compound ingestion.

Bleeding in the salivary glands represents a very rare complication of oral anticoagulant therapy. Only one such case has been previously described in the submandibular glands. To the best of our knowledge, we document the first case of hemorrhage in the parotid gland following the ingestion of coumarin compounds.

Administration, Oral

Maturation of auditory brainstem potentials in neonates and infants.

Auditory brainstem evoked potentials (ABP) were recorded in 59 healthy neonates and infants whose age ranged from 3 days to 18 months (6 age groups). Latencies of individual waves and the interpeak latencies (IPL) of I-III, III-V and I-V were analysed. A different maturational pattern was observed in the pontomedullary and the pontomesencephalic segments of the brainstem. Latencies of all waves except wave I were longer in male than in female babies. Establishment of normative data related to the technical variables employed by the individual team is a sine qua non prerequisite for adequate neurological evaluation of ABP.

Auditory Pathways

Sudden hearing loss in the elderly.

In elderly subjects suffering from presbycusis a clinical picture of sudden hearing loss, tinnitus and vertigo may be precipitated by a superimposed serous otitis media. Such an abrupt and dramatic sensory deficiency may be erroneously ascribed to an acute cochlear lesion and given grave prognostication. This situation was observed in 12 patients during a period of 2 years. Appropriate diagnostic evaluation revealed the true nature of the disease and simple therapeutic measures promptly restored the auditory function to its previous level.

Aged

Measurement of auditory brain stem potentials in Bell's palsy.

Auditory brain stem potentials (ABP) were recorded in 27 patients with Bell's palsy during the early phase of the disease and 1-3 months later. Pathological findings were observed in 6 patients, the dominant features being prolonged brain stem transmission time and diminished amplitude of the second wave. The extension of the pathological process in the so called idiopathic peripheral facial paralysis appears to vary. The observation of brain stem involvement in some patients with Bell's palsy may have important clinical implications.

Adult

Auditory potentials of cochlear nerve and brain stem in multiple sclerosis.

Auditory evoked potentials of the cochlear nerve and the brain stem were recorded in ten patients with multiple sclerosis (MS) and four patients thought to possibly have MS. A characteristic pattern materialized, with a prolonged N1-P4 conduction time and absent or small N2 and/or N5 waves. We discuss possible clinical implications.

Adult

Tympanometry in normal neonates.

Acoustic conductance and susceptance tympanograms were obtained at 220 and 660 Hz in 34 neonates. The neonates were categorized into three age groups (8-24 hours, 24-60 hours, and 60-96 hours). Single-peaked, double-peaked, and monotonically increasing tympanograms were found. Static values for conductance, susceptance, admittance, resistance, reactance and impedance at the lateral surface of the tympanic membrane were computed from the tympanograms. There were no significant differences in mean static values among the three groups. At 220 Hz, the individual static reactance values were usually smaller than the static resistance values and often assumed a positive sign. At 660 Hz, the individual static reactance values always assumed a negative sign and were approximately equal to the static resistance values. The single- and double-peaked tympanograms apparently were the result of previously identified interactions between static resistance and reactance values. The data were compared to those of infants and adults. Tympanograms at 220 Hz were obtained for 13 of the original subjects at the age of three to four months. The data collected in this group were consistent with those reported in the literature for the same age group.

Acoustic Impedance Tests

Nasopharyngeal cancer in a total population: selected clinical and epidemiological aspects.

A nationwide study of nasopharyngeal cancer in Israel, during a 9-year period (1960-68) demonstrated a mean annual incidence rate of 1.0 per 100,000 in males and 0.4 per 100,000 in females. Significantly higher incidence was observed in residents born in North Africa (3.0 in males and 1. 1 in females). Survival was relatively better in females among patients with lymphoepithelioma and in those without neurological complications. The results may support the presence of environmental factors in aetiology, though genetic predisposition cannot be ruled out.

Adolescent

Otoadmittance in normal subjects.

Otoadmittance audiometry was performed on a group of young subjects (18-30 years old) with normal hearing. Mean values and standard deviations for static admittance, conductance and susceptance were computed on the basis of the point of maximum compliance, as well as the point of zero cross (drum-free position). In addition, the values of curve width for conductance and susceptance, middle ear pressure and the threshold of the acoustic reflex for pure tones and interrupted tones were evaluated. Subjects presenting an abnormality of the tympanic membrane were studied as a separate group. The results obtained in this study were compared with those reported in the literature.

Adolescent