Biomedical subjects

E Sherrard

Publications and source records attributed to E Sherrard.

3 recordsLinked to original sources

PubMed1992

Central conduction time in childhood autism.

To investigate the integrity of the brain-stem in 20 mentally handicapped children who met the Rutter criteria for autism, brain-stem auditory evoked potentials were obtained for a range of stimulus intensities. Central conduction times (CCTs) were calculated for the Wave I-Wave V interval of the brain-stem potentials. In children under 14 years of age CCTs were normal. In children 14 years of age and over, three of four girls and eight of nine boys had CCTs exceeding normal limits when compared with a group of controls of normal intelligence, matched for age and sex. CCTs recorded from a group of non-autistic mentally handicapped children were within normal limits. The age distribution are consistent with a maturational defect in myelination within the brain-stem in autism, a defect which may have a much wider anatomical distribution throughout cortical and subcortical structures.

Adolescent↗

PubMed1989

Sporadic diffuse corneal endotheliitis.

We studied two patients with acute diffuse corneal endotheliitis who had no family history of the disease. Endothelial specular photographs taken during and after an attack of endotheliitis demonstrate the deposition of inflammatory material on edematous endothelial cells, with areas of focal endothelial cell loss that resolved with treatment. These cases are distinctly different than the previously described "idiopathic" primary endotheliitis entities, which have included focal or sectoral areas of corneal edema, corneal edema in association with a migrating rejection line, or diffuse edema occurring as a dominantly inherited condition. No definitive causative agents have been established. It is likely that the disease results from an immune response to autoantigens or antigens from an unidentified viral infection. The pathogenesis may be similar to that of corneal homograft rejection.

Adult↗

PubMed1987

[Soft contact lenses and the corneal epithelium: experimental study with the scanning microscope].

Thick contact lenses 0.70 mm, of 30% water content, base curve 7.2 mm, power 1,18.00 D, have been fitted to rabbit eyes. After 35 minutes the alterations of the corneal epithelium have been studied using the electronic microscope. The following alterations have been noticed: an increased desquamation in superficial epithelial cell was observed, this detachment was observed only in the surface layer of the corneal epithelium, the number of medium and dark epithelial cells was more important and a significant decrease in microvilli was noted. The study demonstrated in vivo changes in surface cells in rabbit corneal epithelium under an hydrophilic contact lens. These alterations may play a role in the pathogenesis of some clinical problems in patients with soft contact lens.

Animals↗