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Biomedical subjects

E Shimada

Publications and source records attributed to E Shimada.

At least 37 records · Page 2Linked to original sources
PubMed1987

A case of acute poisoning with fenitrothion (Sumithion).

A 56-year-old male attempted suicide by ingestion of about 60 ml of 50% fenitrothion (Sumithion) emulsion. Five hours later, combined hemoperfusion and hemodialysis (HP-HD) treatment was performed for 60 min and consequently the toxic symptoms improved gradually. However, cholinergic symptoms recurred 4 days after ingestion. Although HP-HD was immediately performed for 180 min, it had no effect on the clinical symptoms. He died of respiratory insufficiency 6 days after the ingestion of fenitrothion. Fenitrothion concentration in the organs and tissues showed the highest values in the fat tissue, followed in decreasing order by the pancreas, muscle, lung and brain. The results indicate that fenitrothion has high lipid solubility and deposits in the fat tissue. Furthermore, we believe that when HP-HD therapy is used in the treatment of acute insecticide poisoning it is important that it be performed continuously and in as early a stage as possible.

Acute Disease↗
PubMed1984

Thin-layer chromatography of hyaluronate oligosaccharides.

Odd- and even-numbered hyaluronate oligosaccharides with N-acetylglucosamine, glucuronic acid, or 4,5-unsaturated glucuronic acid at their nonreducing ends were separated by thin-layer chromatography, using silica gel and a solvent system of isopropanol-water (66 : 34) containing 0.05 M NaCl. In the isopropanol system, small amounts of electrolytes were necessary for the resolution of each oligosaccharide.

Acetylglucosamine↗
PubMed1983

[Hypertrophic cardiomyopathy presenting ECG changes mimicking myocardial infarction during 18 years: report of a case].

This report describes a 54-year-old man with hypertrophic cardiomyopathy whose electrocardiogram had developed abnormal changes characterized by progressive ST-segment elevation with Q waves during eighteen years period. The ECG taken on the initial examination at his age of 36 showed a high voltage QRS complex with deep inverted T waves in V3-6. Twelve years later, these inverted T waves became shallow and ST-segment elevation was recognized. Since the age of 49, the ECG showed persistent ST-segment elevation and Q waves in V3-6 mimicking anterolateral myocardial infarction. At the age of 54, he suddenly died of ventricular tachycardia. At necropsy the heart showed the thickened ventricular septum and transmurally infarcted scar in the anteroseptal area near the apex with patent epicardial coronary arteries. Microscopic examination revealed myofibrillar disarray in the ventricular septum and significant intramural coronary artery narrowing in the left ventricular free wall and ventricular septum. The association of myocardial infarction in hypertrophic cardiomyopathy with the patent epicardial coronary artery has been reported by Maron et al, who stressed the role of the narrowing of intramural coronary arteries in such cases. In the present report, we discussed the pathogenesis of myocardial infarction in hypertrophic cardiomyopathy with a review of literature.

Cardiomyopathy, Hypertrophic↗
PubMed1981

[Clinical study on left atrial thrombi: comparative study between echocardiography and CT scan (author's transl)].

We studied left atrial thrombi (LAT) by both echocardiography and computed tomography (CT) and compared the features of the 2 methods. A total of 15 patients with mitral stenosis complicated by atrial fibrillation were selected as the subjects. LAT were noted on the M-mode echocardiograms in 2 patients including a questionably positive one, on the two-dimensional echocardiograms in 5, and on the CT scans in 6 of 15. The history of thromboembolism was rather frequent and was found in 7 of 15 patients. However, LAT was found in only 3 of these on the CT scans. A shaggy or fuzzy pattern on the M-mode echocardiogram cannot be regarded as representing thrombi, while a laminar pattern undoubtedly represented thrombi. Two-dimensional echocardiography has considerably contributed to the improved detection rate of LAT. For the characteristic properties of ultrasound beams, however, it was impossible to investigate the entire left atrium. The detection of the thrombi in the appendage was especially difficult. However, computed tomography, permitting transverse cross-sectional tomography, was capable of sectioning the heart even in the presence of air and bones. The measurement of CT values was suggestive of the properties of the substance or substances involved, and also allowed the presumption as to whether the thrombus has been fibrosed. Furthermore, it was possible to estimate more accurately as well as 3-dimensionally the location, shape and dimensions of the thrombi by the reconstruction of the heart according to the CT values. It was concluded that echocardiography and computed tomography are the mutual aid to further improvement in the detection rate of left atrial thrombi.

Aged↗
PubMed1980

Degradation process of hyaluronic acid by Streptomyces hyaluronidase.

Saturated and unsaturated hyaluronate oligosaccharides were prepared from human umbilical cord hyaluronic acid by partial digestion with bovine testicular and Streptomyces hyaluronidase, respectively. After treatment with Streptomyces hyaluronidase, the distribution of degradation products from these oligosaccharides was determined. Octasaccharides, either saturated or unsaturated, were substrates of the minimum size. Tetra- and hexasaccharides were not degraded further and remained as final products. This indicates that at least four succeeding N-acetylhyalobiuronosyl residues were required for this enzymatic degradation. Since unsaturated oligosaccharides were more susceptible to this enzyme than saturated ones of the same polymerization degree, and inner glucosaminidic linkages were cleaved in preference to those at the outermost sites, some groups adjacent to this segment seemed to influence the susceptibility of the oligosaccharide to this enzyme.

Animals↗
PubMed1980

The relation between mercury levels in brain and blood or cerebrospinal fluid (CSF) after mercury exposure.

Rabbits were exposed to elemental mercury (Hg degrees) vapor, methyl mercury (MeHg) and HgCl2 respectively, and the relationship of mercury concentration in brain to that in blood or cerebrospinal fluid (CSF) was investigated after the termination of exposure. At one day post-exposure, the ratio of mercury concentration in brain (microgram Hg/g) to that in blood (microgram Hg/g) was approximately 10.0 in Hg degrees vapor, 0.6 in HgCl2 and 3.0 in MeHg. The ratio for Hg degrees vapor was about 10 times higher than that for HgCl2. In rabbits exposed to Hg degrees vapor, the ratios of mercury concentration in blood to brain or CSF to brain at 1 day and 20 days after the termination of exposure were compared. The blood to brain ratio showed a decrease to about 1/10 after 20 days, and the CSF to brain ratio, a decrease of about 1/2. The results obtained seems to suggest that mercury is eliminated from the blood and CSF more rapidly than from the brain. In the case of rabbits administrated MeHg, the ratio of mercury concentration in blood to that in brain was almost unchanged at both 1 day and 20 days after the termination of exposure. There did not seem to be any differences in the rates of elimination from blood and brain. The elimination of mercury from CSF was more rapid than from brain because the ratio between the mercury concentration of CSF to that of brain showed a decrease to about 1/3 after 20 days.

Animals↗