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Biomedical subjects

E Simonsen

Publications and source records attributed to E Simonsen.

At least 91 records · Page 5Linked to original sources
PubMed1984

Stage I squamous cell carcinoma of the vulva.

Eighty-six patients with invasive squamous cell carcinoma of the vulva stage I were followed for 2 to 20 years after surgical treatment varying from local excision to radical vulvectomy with inguinal lymph node dissection. The results are presented and the prognosis discussed in relation to the radicality of the surgical intervention, the degree of tumour differentiation, the morphologic properties of tumour cell population, and the tumour host relationship. The most important prognostic factor seemed to be the radicality of the surgical intervention. To reduce patient morbidity in radical surgery while still achieving a comparable survival rate an operative approach with less than radical vulvectomy, inguinal dissections or pelvic lymphadenectomy, or both, is proposed for selected patients.

Actuarial Analysis↗
PubMed1984

Spontaneous rotation of permanent pacemaker--a cause of muscle stimulation and myopotential inhibition.

In 5 of 192 patients who received their first pacemaker during a 17-month period, severe pectoral muscle stimulation was caused by spontaneous rotation of the pacemaker in the pocket, so that the uncoated side faced backwards. All five patients were women with abundant, loose subcutaneous tissue which allowed increased mobility of the pacemaker. This causal mechanism of muscle stimulation seems to be related to the reduced size and the coating of modern pacemakers. Reprogramming of the pacemaker to a lower output solved the problem in three cases, but reoperation was necessary in two. These cases stress the need to secure the pacemaker to the fascia during implantation, particularly in patients at enhanced risk. For such patients, use of a pacemaker equipped with suture holes may be advisable.

Aged↗
PubMed1984

Invasive squamous cell carcinoma of the vulva.

Clinical data on 266 patients with squamous cell carcinoma of the vulva seen between 1960 and 1979 are reported. Two-hundred and eleven of these patients were eligible for 5-year evaluation. The crude survival for these patients was 59%, and the 5-year crude survival for 195 patients treated with curative intention was 64%. Two-hundred-forty-four patients were treated with radical vulvectomy and in 122 patients lymphadenectomy was also performed. Fifty per cent of the patients treated with lymphadenectomy had lymph node metastases at the time of surgery. In 88% radiotherapy was included in the treatment of the regional lymph node regions. Treatment failures occurred in 25% of the patients. Prognosis was discussed in relation to tumour size, tumour site, and histological differentiation. The presence of lymphatic involvement and surgical radicality appeared to be the most significant prognostic factors.

Adult↗
PubMed1983

Bleomycin-mitomycin C in advanced carcinoma of the cervix. A third look.

Thirty-three patients with advanced cervical cancer (31 squamous cancer, two adenosquamous cancer) previously untreated with cytotoxic drugs, were treated with bleomycin, 5 mg daily, for seven days and mitomycin C, 10 mg, on day 8. This regimen was repeated four times at two-week intervals. All but one patient had previously been treated with radiotherapy; 36% of the patients had an objective response (five complete remission (CR), median duration 12 months; seven partial remission (PR), median duration six months). Severe myelosuppression occurred in nine patients. One drug-related death due to thrombocytopenia occurred. Three patients developed pulmonary fibrosis and one of them died of respiratory failure. The bleomycin-mitomycin C regimen has a definite but clearly limited effect in advanced cancer of the uterine cervix.

Adult↗
PubMed1983

CO2 laser for the treatment of invasive vulvar and vaginal cancer.

In a material of 21 patients including 7 primary and 6 recurrent vulvar carcinomas, 5 vaginal carcinomas, 1 urethral carcinoma and 2 preinvasive vulvar carcinomas operation was performed with a CO2-laser scalpel. In 9 radical and 3 partial vulvectomies no primary closing of the wounds was performed. In the remaining primary closing was performed. The operative bleeding and healing process with laser scalpel and electrosurgical scalpel using open wound technique were about the same. The surgical time was longer with the laser technique but the operative specimens were better preserved. Healing of the primary closed wounds were uncomplicated.

Carbon Dioxide↗
PubMed1982

The recovery pattern of patients with vulvar melanoma treated by combined surgery and radiation therapy.

Twenty-five patients with malignant vulvar melanoma have been treated with radical vulvectomy using the warm knife-open wound technique. Following preoperative radiation therapy, dissection of the groin and, in some cases, pelvic lymphadenectomy, were performed as a second procedure. Crude five-year survival was 9/21 (approximately 43%). Patients with tumours of Clark level II--IV have been found to have a good prognosis (7/9), while those with Clark V-tumours have had an extremely poor prognosis (2/10). Prophylactic dissection of the inguinal nodes has not been found to improve the prognosis, and pelvic lymphadenectomy is considered to be inadvisable.

Adult↗
PubMed1980

Sinus node dysfunction in 128 patients. A retrospective study with follow-up.

A retrospective study covering all admissions during a 6-year period revealed 128 patients with sinus node dysfunction (SND). The patients were grouped according to the ECG criteria chosen: group I 33 patients with sinus bradycardia, group II 37 with sinoatrial block/sinus arrest, group III 58 with brady-tachy syndrome. Additional heart disease, predominantly ischaemic, was found in 56%. The frequency and severity of symptoms increased from group I to group III. Pacemaker treatment was given to 40% of the cases, while medical treatment alone was successful in 17%. A follow-up including 104 patients was carried out after a mean observation period of approximately three years. Sixteen patients had died. The cause of death may have been SND per se in only one case. Five patients died of apoplectic insults or complications to such. In total, nine possible or proven systemic embolic events were found--all occurring in patients with brady-tachy syndrome. A progression of the ECG abnormality from a lower to a higher group took place in nine patients during the observation period. It is concluded that SND is a condition with a broad clinical spectrum and a stationary or slowly progressive course. In general, it carries a good prognosis. A substantial number of deaths of disabilities in patients with brady-tachy syndrome may be ascribed to systemic embolism. Long-term anticoagulant therapy is proposed in this subgroup of patients with SND.

Adult↗
PubMed1980

Sinus node dysfunction in acute myocardial infarction.

In a retrospective study of patients admitted for acute myocardial infarction (AMI) during six years, sinus node dysfunction (SND) was detected in 20 (1.04%). Twelve had persistent sinus bradycardia, 11 sinotrial block or sinus arrest and six bradytachy syndrome. Symptoms occurred in 17 patients, 12 of whom required temporary pacing for periods up to three weeks. A permanent cardiac pacemaker was implanted in three patients with brady-tachy syndrome. Three patients died during the primary admission and six during the observation period. Follow-up after a mean observation period of 34 months showed continuous signs of SND in 11 out of 19 patients. The arrhythmia caused symptoms in five patients, two of whom had a cardiac pacemaker and two received medical treatment. It is concluded that SND appearing during an AMI persists in a high number of these patients.

Aged↗
PubMed1979

Significance of the acetylation phenotype and the therapeutic effect of procainamide.

In order to estimate the relative anti-arrhythmic effect of procainamide and N-acetyl-procainamide, 18 randomly selected, patients with arrhythmia were divided into two groups; the first was treated with Pronestyl in the first half of the investigation period, followed by Duretter in the second half, and the second group began with Duretter and terminated with Pronestyl. The concentrations of procainamide and N-acetylprocainamide were measured twice a day during the steady state part of each treatment period. The acetylation phenotype of the patients was determined with sulfadimidine, and compared with the relative serum concentrations of procainamide and N-acetylprocainamide. N-acetylprocainamide was found to antagonize the action of procainamide.

Acetylation↗