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Biomedical subjects

E Simonson

Publications and source records attributed to E Simonson.

At least 19 recordsLinked to original sources

Osteogenic sarcoma and cisplatin chemotherapy in dogs: 16 cases (1986-1989).

Sixteen dogs, given adjuvant cisplatin chemotherapy after amputation for osteogenic sarcoma of the appendicular skeleton, had a median survival time of 413 days. Ten dogs (62%) were alive 1 year after amputation. Dogs were given cisplatin at a dosage of 50 mg/m2 of body surface every 4 weeks for a total of 6 cisplatin treatments, or until metastatic disease was detected. Cisplatin chemotherapy was well-tolerated by most dogs, with only 1 dog developing serious gastrointestinal toxicosis, requiring hospitalization. Results of this study support other investigators' findings that when a cisplatin chemotherapy-based protocol is administered, survival times after amputation can be prolonged for dogs with osteogenic sarcoma.

Amputation, Surgical

The electrocardiogram in epidemiologic investigations. A new classification system.

A new coding system for ECG abnormalities was developed, based on Frank's orthogonal ECG leads. In contrast to other systems, such as the Minnesota Code (MC), the new system was based on data collected prospectively in a cooperative study of 5031 records. The records were classified solely on the basis of non-ECG information. A record sample from normal women was also available. The large data base allowed stratification of ECG criteria according to sex and race. ECG criteria were determined at two levels of sensitivity and specificity. Specificity was 80-100% at the first level and 90-90% at the second. The new system has fewer criteria than other codes, which leads to reduction of coding errors and coding time. For common problems in differential diagnosis, optional criteria were included. A computer program for automated coding was also developed.

Adolescent

Analysis of discrepancies between VCG and ECG interpretation of anterior wall myocardial infarction.

In 247 cases in which an old anterior myocardial infarction (MI) was suspected and in which SVEC III-lead system vectorcardiograms (VCGs) and matching conventional 12-lead electrocardiograms (ECGs) were available, records were analyzed to investigate the diagnostic agreement or discrepancy between the two techniques. The frequency of agreement (155 cases) exceeded the frequency of disagreement (92 cases), but the frequency of disagreement even with lumped subgroups was high. Eighty percent of this disagreement was between positive VCG and negative ECG diagnostic consensus. The positive MI group by ECG diagnosis showed smaller R waves and larger S waves and larger S waves in leads V2 and V3 and smaller R/S ratios in leads V2 and V4 than the negative MI groupe by ECG, while small R waves or QS patterns and large S waves in just lead V1 were the only positive finding in the positive MI group by VCG. The important VCG characteristic for positive MI diagnosis was abnormal posterior deviation of the initial QRS vectors. The high incidence of discrepancies shown by positive VCG and negative ECG diagnoses resulted from the fact that, in spite of the presence of a fairly well developed R wave in precordial leads, the initial QRS vectors were displaced posteriorly. In 8 of 18 cases classified into negative VCG and positive ECG diagnostic group, poor R wave progression did not necessarily result in the posterior displacement of the initial QRS vectors. In contrast to the difficulties in applying ECG criteria for anterior MI (variability of QRS patterns in precordial leads), an orthogenal VCG (representing the phasic changes in the depolarization process) seems to clarify the equivocal situation in the ECG diagnosis of MI.

Electrocardiography

Hans Schaefer's asystole: two case reports.

Two cases of myocardial infarction are reported with transient (case 1) or permanent (Case 2) recovery of an R wave in anterior chest leads in the acute epsiode. This observation confirms H. Schaefer's hypothesis of asystole of the affected area, i.e. electrical inexcitability without necrosis. This phase precedes necrosis in any acute infarction; in the large majority of cases, myocardial infarction ultimately develops; therefore, demonstration in a clinical follow-up is quite rare.

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