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Biomedical subjects

E Sobata

Publications and source records attributed to E Sobata.

7 recordsLinked to original sources
PubMed1991

Role of platelet function in symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

To evaluate the role of platelet function in the pathogenesis of cerebral vasospasm, we compared sequential changes of platelet aggregability and beta-thromboglobulin and thromboxane B2 concentrations in blood samples from the internal jugular and peripheral vein of 13 patients with aneurysmal subarachnoid hemorrhage. Platelet function in blood from the internal jugular vein tended to be enhanced during days 0-1 but recovered to the normal range during days 2-4. After day 5, platelet function showed various patterns depending on the presence of symptomatic vasospasm. In patients without symptomatic vasospasm, sequential changes were relatively minor, with normal or slightly high values. Patients with symptomatic vasospasm already showed high platelet aggregability during the early stage of vasospasm. The concentration of beta-thromboglobulin increased several days after the onset of vasospasm, reaching 80 ng/ml or more in patients with a poor prognosis. Two of the five patients with symptomatic vasospasm showed markedly high concentrations of thromboxane B2 after day 8. These results suggest that vasospasm activates platelets and promotes aggregability and that the resulting increased tendency for thrombus formation may affect the patient's prognosis during the advanced stage.

Adult↗
PubMed1988

Cerebrovascular disorders associated with von Recklinghausen's neurofibromatosis: a case report.

A 28-year-old woman with von Recklinghausen's neurofibromatosis (NF-1) had a huge hematoma in the left posterior nuchal region. Carotid and vertebral angiograms revealed marked stenosis at the C3 portion of the left internal carotid artery, slight moyamoya staining, occlusion of the left vertebral artery at the atlas level, and a right internal carotid artery aneurysm. The radiographic, clinical, and histological features of this case are discussed together with a review of 42 similar cases found in the literature.

Adult↗
PubMed1986

Dural sinus pressure: various aspects in human brain surgery in children and adults.

To prevent air embolism and minimize neurosurgical venous hemorrhage, the dural sinus pressure (confluens sinuum pressure, CSP) was examined under various conditions in 47 cases, 11 of whom were children. Either the extracranial (group A) or catheter type (group B) pressure transducer was used. The latter gave approximately 30% higher values than the former. In any surgical position, children showed a tendency toward higher pressure than did adults. This was particularly the case in the sitting position; adults showed negative pressure [-8.6 +/- 2.3 (SD) mmHg, group A], whereas all eight children less than 9 yr of age (group A, 5 cases; group B, 3 cases) showed positive pressure. The youngest with negative CSP in a sitting position was a 9-yr-old boy. When the upper half of the body was raised, the CSP decreased linearly and became zero at approximately 25 degrees. In anteflexion of the neck, the CSP decreased significantly, and even with inclination of the upper half of the body of only 15-20 degrees or more upward, negative pressure was observed in adults. In children, right and left rotation of the neck showed remarkable increase of the CSP. In both supine and sitting positions, CSP was elevated sufficiently by bilateral jugular compression to prevent air embolism. Positive-pressure respiration did not raise the CSP, contrary to widely accepted knowledge. This study was originally performed in relation to brain surgery, but the results also seemed to be valuable in physiology.

Adolescent↗
PubMed1986

[Posterior fossa subdural hematoma in neonates: report of two cases and review of the literature].

Posterior fossa subdural hematoma in neonates caused by birth trauma is rare; only 30 clinical cases can be found in the literature so far. Here we experience two similar cases and review that literature. Case #1 is that of a full-term female born in the pelvic position. At 21 hours after birth she developed convulsions and a CT scan revealed a high-density area, mainly in the right posterior fossa. On the fourth day, a right suboccipital craniectomy was performed and about 15 ml of hematoma was removed. At present her mental and somatic development is appropriate for her age (5 months), despite the fact that moderate brain atrophy was seen in the CT scan taken at 4 months. Case #2 is that of a full-term female also born in the pelvic position. At 38 hours she became convulsive and opisthotonic; a CT scan revealed a high-density area in the posterior fossa. No neurological abnormality was seen thereafter, however, and she was treated conservatively. On the 18th day, the high-density area in the CT scan had almost disappeared. In the CT scan taken at 6 months moderate brain atrophy was seen, but at the present age of two she evidences quite normal development both mentally and somatically. These cases lead us to emphasize the importance of prompt diagnosis followed by removal of hematoma, and the usefulness of CT scan as a diagnostic method in clinical manifestations of this sort.

Birth Injuries↗
PubMed1979

[A case of extra-intracranial bypass venous graft for giant internal carotid aneurysm (author's transl)].

A male patient, aged 42, (No. 780624) was admitted to the Department of Neurosurgery of Hirosaki University Hospital, complaining recent weight loss, intolerance to cold and visual disturbance of the right eye. Ophthalmological examination revealed the optic atrophy with decreased visual acuity and concentric visual defect of the right eye. Endocrinological examination showed almost general suppression of adenohypophyseal function except abnormal high level resetting of cortisol diurnal rhythm. Radiological examination revealed the accessory middle cerebral artery and giant internal carotid aneurysm of the right side which was displayed by contrast-enhanced CT scan, with the enlarged sella turcica. Good cross filling was seen in left CAG through the anterior communicating artery. Extra-intracranial end to end anastomosis of the right internal carotid artery was performed with long venous graft under general anesthesia with hypothermia and induced hypotension, on Oct. 26 '78. Unroofing of the right optic canal was very useful to preserve the optic nerve, and the body of the giant aneurysm was opened and sutured tightly to reduce its mass effect. Interlacing suture for the anastomosis of the cervical internal carotid artery was employed successfully. The blood flow of the bypass graft, measured as enough volume with square wave flowmeter during the operation, was also confirmed with postoperative angiography. After the episodes of gastrointestinal bleeding, hypotensive attack and hemorrhagic infarction of right frontal base, the postoperative final result was successful and the patient is doing well, 6 months after the operation.

Adult↗