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E Solsona Narbón

Publications and source records attributed to E Solsona Narbón.

At least 19 recordsLinked to original sources
PubMed2006

[Usefulness of bcl-2 expression as a new basal cell marker in prostatic pathology].

INTRODUCTION AND OBJECTIVES: The diagnosis of invasive adenocarcinoma of the prostate is often difficult in needle prostatic cores, where, additionally, the assessment of the presence of basal cells has demonstrated to be of paramount importance. Currently, the immunohistochemical expression of 34betaE12 antigen and p63 protein are the most utilized markers. In our study, we analyzed comparatively the expression of 34betaE12, p63, bcl-2 and alpha-methylacyl-CoA racemase in order to evaluate the usefulness of bcl-2 as a new marker of the basal cells in prostatic pathology. METHODS AND RESULTS: This study comprises radical prostatectomy specimens from 48 patients which were studied in order to determine the lack of staining of basal cells in invasive tumor areas together with the expression of racemase. Likewise, the presence of basal cells in areas of atrophy, hyperplasia, adenosis, and high-grade prostatic intraepithelial neoplasia (PIN) was also examined. Within the areas of adenosis and PIN a discontinuous pattern of basal cell expression was found in some cases. In 2 out of 48 cases (4,2%) of invasive carcinoma a weak bcl-2 expression without a basal cell distribution was found. Moreover, the expression of bcl-2 in the stromal lymphocytes appeared to be essential as an internal positive control of the technique. CONCLUSIONS: In addition to classical markers, we demonstrated the diagnostic value of bcl-2 as a new basal cell marker.

Adenocarcinoma↗
PubMed2006

[Radical laparoscopic nephrectomy].

In this article, we review the different surgical approaches to carry out radical laparoscopic nephrectomy: transperitoneal approach, retroperitoneal approach and hand-assisted approach. We describe the advantages and drawbacks of each alternative and summarize the most important references in the medical literature. In spite of this being a relatively new surgical approach, less than 15 years old, it has become a standard treatment and, today, is considered as the elective surgical treatment for T1 and T2 renal tumours in many centres.

Humans↗
PubMed2005

[Radiation-induced infiltrating transitional cell carcinoma].

INTRODUCTION: The increased risk of developing a transitional cell carcinoma (TCC) among patients irradiated for other pathologies in a known fact, but many times forgotten due to its low incidence. Our aim is to review the association between radiotherapy (RT) and muscle-infiltrating TCC among our patients. MATERIAL AND METHODS: Clinical survey among our muscle-infiltrating TCC data base since 1975. Descriptive analysis of found cases. RESULTS: We found 5 patients who developed muscle-infiltrating TCC with a mean time of 19.2 years since radiotherapy (three of them more than 20 years and the other two less than 10 years). Three patients also developed other tumours or pathologies related to radiotherapy. Two of them had an upper tract muscle-infiltrating TCC and required nephroureterectomy. All of them had high risk TCC of the bladder and one developed distant metastasis. CONCLUSIONS: Patients under abdomino-pelvic RT and a prolongued follow-up, can be considered a risk group for developing muscle-infiltrating TCC. Thus, either micro or macrohaematuria or irritative symptoms should lead us to think in this possibility, demanding complete and exhaustive study to rule out TCC in all the urothelium.

Aged↗
PubMed2004

[Usefulness of serum markers in renal cell carcinoma].

OBJECTIVES: To select a group of useful serum markers in renal cell carcinoma (RCC) with investigational purpose in future. MATERIAL AND METHODS: Periodic determination in serum of 21 RCC patients of the following markers: EGR, RPC, hemogram and leucocyte differential count (LDC), standard biochemist parameters, beta-2 microglobuline, CEA, CA 12.5, CA 50, CA 15.3, ferritin, interleukin-6, serum interleukin-2 receptor, TNF-alpha and TPSA. RESULTS: Different elements within the LDC had relations with the presence of symptoms/signs, tumour size, pathological stage and disease progression. There was a significant increase of beta-2 microglobuline and sIL-2 receptor when disease progressed, as well as a similar statistical trend with RPC and alkaline phosphatases. Beta-2 microglobuline and sIL-2 receptor also decreased after treatment of the disease progression. CONCLUSIONS: We will keep analysing hemogram, LDC and standard byochemics, RPC, ferritin, beta-2 microglobuline and sIL-2 receptor only with investigational purposes, obviating the determination of the rest of the tested markers.

Biomarkers, Tumor↗
PubMed2004

[Treatment of post radical prostatectomy erectile dysfunction with sildenafil in a non-selected group of patients].

OBJECTIVE: To evaluate erectile disfunction (ED) after radical prostatectomy in a non selected group of patients and their response to sildenafil. METHODS: We included our patients who were operated on between 1998 and 2001. The patients filled in a modification of IIEF (mIIEF) before the RP operation. We tried sildenafil with doses of 100 mg in 3 different periods: 3-6, 12 and 18-24 months after the RP operation. In the event of a complete response they filled in the mIIEF again. RESULTS: The mean age of the patients was 62.8 years old and the mean observation period was 31.7 months. Only 111 (62%) of the total number of patients operated on wanted treatment and only 90 took sildenafil in the proposed protocol; 27 (30%), 18 (20%) and 45 (50%) patients had a complete response, a partial response or no response to the sildenafil respectively. The mIIEF showed 6.5+/-5.7 points less than the mIIEF pre-treatment. In the univariate analysis, the preservation of bundles, the presence of a previous partial response and the presence of the previous tumescence were significantly related to the complete response; however, only tumescence kept its value in the multivariate study. CONCLUSIONS: Urologists must involve themselves in the early rehabilitation of the erectile function even in those patients where preservation of the NVB was not possible. One must always try to preserve, uni or bilaterally, whenever the patient desires preservation of EF. The response to sildenafil is better after the first year and in patients who have previous tumescence.

Aged↗
PubMed2002

[Assessment of the basal membrane status as prognostic factor in renal carcinoma].

OBJECTIVES: To know the basal membrane (BM) integrity in renal cell carcinoma (RC) and its importance as prognostic factor. MATERIAL AND METHODS: 73 patients with RC were selected. Immunohistochemistry with monoclonal antibodies against basal proteins laminin and collagen IV was performed. Percentage for BM fragmentation in the whole tumour was considered taking 75% as cut off. RESULTS: Follow-up was 6.3 +/- 4.3 years and 27 patients progressed. Correlation between laminin and collagen IV was significative (p = 0.000). A BM fragmentation expressed with laminin bigger than 75% was related to tumoural symptoms (p = 0.019), worse grade (p = 0.004) and necrosis in more than 10% of the tumour (p = 0.000). Fragmentation observed with collagen IV was associated to tumours greater than 7 cm (p = 0.014). Those patients whose tumours displayed more than 75% of BM fragmentation, measured with collagen IV, presented worse survival (p = 0.042). A similar trend was observed in the case of laminin, but it did not reach statistic significance (p = 0.119). In the unvariated analysis grade III-IV, more than 10% of necrosis within the tumour, tumoural symptoms and BM fragmentation bigger than 75% measured with collagen IV were prognostic, while only grade and necrosis did so in the multivariate analysis. CONCLUSIONS: Collagen IV and laminin represent nicely, with a similar expression pattern, the BM fragmentation in RC. Within a battery of immunohistochemical markers to study RC at least one of them should be included because their prognostic implication.

Basement Membrane↗
PubMed2002

[Penile cancer].

Penile carcinoma is a tumoral condition of inconsistent incidence. Its biological and etiological features are under permanent scientific review. Such circumstance is increased by the growing awareness of a greater demand of anything related with the patients' quality of life. This paper reviews the latest controversies guiding current therapeutic approaches in penile cancer. An analysis is made through a revision of the lymphadenectomy indication and its therapeutic value, criteria related to technical aspects and indications. At the same time, the criteria that should preside over the choice between conservative or radical options are established and emphasis is placed on the growing role of prevention in tumoral conditions and the contribution of innovative gene therapy regimes.

Humans↗
PubMed1998

[Adrenal gland incidentaloma in the oncologic patient: is its histologic study obligatory?].

OBJECTIVES: To analyze the need for histological study in suprarenal incidentalomas in the specific status of the oncological patient. MATERIAL AND METHODS: 21 patients with tumoral suprarenal masses, 12 diagnosed in the initial study and 9 during the follow-up RESULTS: 16 masses were benign in nature and 5 were metastatic. Neither the location nor the staging of the initial tumour, the time of diagnosis, or the hormonal study were of any use to separate the primitive tumour from the metastasis. All metastasis were equal to or greater than 5 cm in size. Radiological study only confirmed the nature of the tumour in a few cases. Percutaneous biopsy was resolutive in 4/8 cases (50%). Suprarenalectomy was performed in 15 occasions, associated in 10 to surgical treatment of the primary therapy with not added morbidity. CONCLUSION: When incidentaloma is detected in tumoral patients at the time of diagnosis, it requires an histological study which in 1 out of 3 cases will modify the therapeutic attitude in the presence of metastasis. If the incidentaloma is detected during follow-up, it may be monitored in terms of evolution as we would only be delaying a palliative treatment.

Adrenal Gland Neoplasms↗
PubMed1993

[Bladder carcinosarcoma. Report of 2 cases].

Two additional cases of this rare bladder tumor are described. The immunohistochemical analyses confirmed the histological diagnosis of this aggressive tumor type. The choice of treatment for the tumor and its metastasis is influenced by its rarity.

Aged↗
PubMed1992

[Results of a randomized, double blind prospective study of intravesical chemoprophylaxis with 2 drugs: adriamycin and mitomycin; and 2 ways of initiating the instillations: early and late. Effect on recurrence and progression].

The results of a double blind prospective study comparing the chemoprophylactic effects of adriamycin and mitomycin C and two modes of instillation (early: 6 hours following transurethral resection; late: 7-14 days later) for superficial carcinoma of the bladder are presented herein. Since the minimum follow up is over 5 years, the effects on tumor progression and mortality achieved by each of the 4 arms of the protocol were also evaluated. Concerning tumor recurrence, early instillation of mitomycin and overall early instillation therapy achieved significantly better results (p < 0.01). No differences, however, were observed relative to tumor progression or mortality.

Administration, Intravesical↗
PubMed1992

[Mitoxantrone (MTX) versus mitomycin C (MMC) in the ablative treatment of Ta, T1 superficial bladder tumors. Phase III, randomized prospective study].

A prospective randomized study was conducted to determine the ablation capacity of mitoxantrone in Ta-T1 superficial bladder tumors versus mitomycin C, a drug whose intravesical ablation properties are well-known. Fifty-seven patients comprised the study. The tumor was not completely resected when the patient underwent TUR. This residual tumor was used as control. The patients were treated with either 20 mg Mitoxantrone or 40 mg mitomycin C weekly for 8 weeks and two other instillations every 15 days in 50 ml saline solution. Response to therapy was evaluated between the 4th and 8th week and classified as complete response (CR), defined as no gross and microscopic evidence of residual tumor, or no response (NR) or therapeutic failure. CR was observed in 77.7% of the patients treated with mitomycin C and in 50% in those that had been treated with Mitoxantrone. Treatment was discontinued because of side effects in 15% of the patients treated with mitomycin C and in 63.4% of those who received Mitoxantrone. We can conclude from the results of the present study that Mitoxantrone is a useful agent for ablation therapy of superficial bladder tumors, although the high incidence of severe side effects warrants its limited use and at high dilutions.

Female↗
PubMed1991

[Tumor embolization to the lymphatic vessel structures of the bladder wall (L+). Its effect on the course of bladder tumors].

A retrospective study was conducted in patients with bladder tumors equal to or higher than stage T1 to determine the influence on survival of tumor cell invasion of the microscopic lymphatic vessels of the bladder wall. Sixty-two patients were studied (34 recurrent and 28 primary tumors). Evidence of microscopic lymphatic invasion was disclosed following TUR (48 cases) and cystectomy (14 cases). Overall and with a mean follow up of 27 months, 25% of the patients are alive and tumor free, 51.6% had died from the tumor (90% less than 3 years following diagnosis). Forty-five percent had lymph node metastasis and 56.6% node and organ metastases. For a time interval of over 6 months between the diagnosis of L + and definitive treatment, there was an 80% mortality versus 43% when treatment was concurrent with diagnosis. Finally, survival was much better in patients submitted to radical surgery. We can conclude from the present study that evidence of tumor invasion of the lymphatic vessels must be routinely sought by the pathologist in order to identify those patients with a high probability of tumor dissemination.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[Reliability of computerized axial tomography (CAT), for the evaluation of lymph node involvement in patients with infiltrating bladder tumor].

The present study was undertaken to determine the reliability of CAT scanning in the preoperative evaluation to detect or discard pelvic lymph node involvement in patients with infiltrating bladder tumor. We compared the radiologic findings with the results of histopathologic examination of the lymph nodes following lymphadenectomy or biopsy of nodes with gross evidence of tumor spread. A comparative study performed in 84 patients revealed a sensitivity rate of 36.3%, a specificity of 87.2%, and an accuracy rate of 66.2% for CAT scanning and, although radiologic evaluation afforded good results, pelvic lymphadenectomy continues to be the method of choice for correct staging of infiltrating bladder tumors.

Female↗
PubMed1990

[Incidence of vesico-ureteral reflux after endoscopic surgery of superficial tumors of the bladder. A prospective study].

The present retrospective study was undertaken to determine the true incidence of vesicoureteric reflux after transurethral resection (TUR) of superficial bladder tumors. The possible role of tumor size, number, site, etc., relative to the appearance of reflux were analyzed, and the principal pathogenic factors involved in iatrogenic vesicoureteric reflux were determined. The incidence of reflux was studied using pre and postoperative ureterocystograms. The study revealed the presence of vesicoureteric reflux long after TUR in 20.6% of the patients.

Adult↗
PubMedDate not supplied

[Surgical treatment of stage I germ cell tumor of the testis].

OBJECTIVE: To analyze the current role of surgery in the treatment of stage I testicular germ cell tumors. METHODS: We reviewed the literature on stage I testicular germ cell tumors. The technique of orchidectomy, the arguments in favor of retroperitoneal lymphadenectomy, the evolution of this technique and the prognostic factors that might be useful in determining the therapeutic approach to stage I testicular germ cell tumors are analyzed. RESULTS/CONCLUSIONS: Treatment of testicular germ cell tumors should be performed in specialized centers that can offer all the therapeutic possibilities with a maximum guarantee so that the patient can decide on the treatment after receiving all the information on the advantages and disadvantages of each modality. Retroperitoneal lymphadenectomy with preservation of sympathetic innervation preserves ejaculation. Its cure rate is similar to that of other therapeutic options, it carries a minimum morbidity, follow-up is simplified, patient anxiety is reduced and there are long-term savings on costs.

Germinoma↗