[Vaccination for foreign travel].
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Biomedical subjects
Publications and source records attributed to E Stahel.
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A case of mixed schistosomiasis in an African female immigrant from Cameroon is reported. Schistosoma mansoni was found in a symptomatic double abscess of the lower lobe of the left lung (1981). S. haematobium was present in the stool and the rectal mucosa but the patient had no symptoms. In Africa the patient had been treated for urinary and intestinal bilharziosis with niridazole in 1979, at which time she did not present pulmonary symptoms. After her arrival to Switzerland (1980) she complained of thoracic pain and bloody purulent sputum. A solitary pulmonary infiltration in the left lower lobe and eosinophilia were noted. Tuberculosis was suspected and, despite negative bacillary findings, trial treatment with tuberculostatics was started. As a smaller infiltration appeared beside the first, left lower lobectomy was performed followed by niridazole treatment. The exceptional diagnosis of pulmonary bilharzioma should be considered in patients with a solitary pulmonary infiltration who come from an area endemic for bilharziosis or who show clinical or laboratory signs of a present or past bilharzial infection.
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The lancet fluke is a common parasite in Swiss sheep and cattle. From 1976 to 1980, 77 patients were found to have eggs of D. dendriticum in the stool. No genuine human infection could be diagnosed, and in all patients the coprologic finding of D. dendriticum eggs had to be considered the result of spurious infections due to the consumption of infected livers. The annual incidence of stool specimens positive for D. dendriticum eggs was between 0.20 and 0.38%.
In a prospective study on a Liberian rubber plantation lasting over 12 months, 79 consecutive patients with recurrent epigastric pain as well as 15 controls without evidence of gastrointestinal disease were endoscoped with a fiberoptic instrument. Peptic ulcers were found in 7 (9%) of the 79 patients; 3 were in the prepyloric antrum and 4 in the duodenal bulb. The incidence of symptomatic peptic ulcer disease estimated from the data was 0.15 per 1000 population per year. Histology revealed superficial gastritis in 34, atrophic gastritis in 23 and duodenitis in 23 of the patients and in 3, 2 and 1 respectively of the control group. The differences observed between patients and controls were statistically significant for the stomach (p less than 0.01) but not for the duodenum. No correlation was found between the presence of histological gastritis and either dietary and social habits or the presence of intestinal parasites.
During a one-year period 95 patients with a history of snake bite were admitted to the hospital of a Liberian rubber plantation. The population at risk included the field workers (tappers and slashers) with an incidence of 4.2 symptomatic snake bites per thousand per year. The incidence of symptomatic bites was 1.7 per thousand in the group of non-field employees and 0.4 per thousand per year in the group of non-employees. The temporary disability was between 3 and 5 days, and the loss of workings days due to snake bites was one day per 10,000 working days on the plantation. Among the 95 patients 27 did not show any symptoms of envenoming except occasional fang marks. 64 patients developed cytotoxic symptoms alone. In this group, the night adder (Causus maculatus) was the main responsible snake. 4 patients showed signs of systemic envenoming. Two were haematological and two were neurological in nature and caused by Bitis species and Naja species, respectively. No fatalities were noted. A definite maximum of snake bites was observed during October and November which corresponds to the transition from rainy to dry season.
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In recent years there has been an increase in imported tropical diseases in Switzerland. Travellers to the tropics are often inadequately or not at all informed about the dangers and possible prophylaxis of infection. This is true for malaria, of which 207 cases covering the years 1974 to 1976 are studied. Most involved were people between 21 and 30 years old. The main infections (71%) come from African countries. Plasmodium falciparum was found somewhat more frequently than P. vivax. Only a seventh of those infected took chemoprophylaxis regularly. Very many took irregular prophylaxis, while scarcely a third ever took an antimalarial drug. All the severe cases were in this group. A review is conducted of aspects of malaria in Switzerland, a country where the disease is not endemic. However, as it can be brought in at any time from tropical areas, it must be considered in the diagnosis of various clinical pictures. As the characteristic course of the fever is rare and onset of the disease often follows later than a month after the return from the infection area, malaria is only recognized late. The diagnosis is nevertheless relatively easy if the possibility of malaria is borne in mind.
A total of 105 patients with mild helminthiases have been treated with ciclobendazole, a benzimidazole derivative related to mebendazole. The treatment lasted 3 days. A group of 74 patients received 200 mg/day ciclobendazole while another 31 patients were given double this dose. The excretion rates achieved were very high at 84.2 and 83.3% respectively in trichuriasis and 93.3 and 100% respectively in ascariasis. In a relatively small number of cases of ankylostomiasis, the values were, however, considerable lower (38.5 and 20.0% respectively). Since ciclobendazole is well tolerated, there is a need for studies with higher dosages and possibly also long-term studies.
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