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Biomedical subjects

E Stanek

Publications and source records attributed to E Stanek.

6 recordsLinked to original sources
PubMed2001

Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults.

BACKGROUND: Increased concentrations of high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, are associated with increased risk for coronary heart disease. Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol. METHODS: One hundred thirteen individuals were scheduled to have five measurements each of hs-CRP and total cholesterol carried out at quarterly intervals over a 1-year period. Variations of hs-CRP and total cholesterol were characterized, and classification accuracy was described and compared for both. RESULTS: The relative variation was comparable for hs-CRP and total cholesterol. When classified by quartile, 63% of first and second hs-CRP measurements were in agreement; for total cholesterol it was 60%. Ninety percent of hs-CRP measurements were within one quartile of each other. This relationship was not altered by the use of log-transformed hs-CRP data. CONCLUSION: hs-CRP has a degree of measurement stability that is similar to that of total cholesterol.

Adult↗
PubMed1999

Effect of physician-delivered nutrition counseling training and an office-support program on saturated fat intake, weight, and serum lipid measurements in a hyperlipidemic population: Worcester Area Trial for Counseling in Hyperlipidemia (WATCH).

OBJECTIVE: To evaluate the effectiveness of a training program for physician-delivered nutrition counseling, alone and in combination with an office-support program, on dietary fat intake, weight, and blood low-density lipoprotein cholesterol levels in patients with hyperlipidemia. PARTICIPANTS AND METHODS: Forty-five primary care internists at the Fallon Community Health Plan, a central Massachusetts health maintenance organization, were randomized by site into 3 groups: (1) usual care; (2) physician nutrition counseling training; and (3) physician nutrition counseling training plus an office-support program. Eleven hundred sixty-two of their patients with blood total cholesterol levels in the highest 25th percentile, having previously scheduled physician visits, were recruited. Physicians in groups 2 and 3 attended a 3-hour training program on the use of brief patient-centered interactive counseling and the use of an office-support program that included in-office prompts, algorithms, and simple dietary assessment tools. Primary outcome measures included change at 1-year of follow-up in percentage of energy intake from saturated fat; weight; and blood low-density lipoprotein cholesterol levels. RESULTS: Improvement was seen in all 3 primary outcome measures, but was limited to patients in group 3. Compared with group 1, patients in group 3 had average reductions of 1.1 percentage points in percent of energy from saturated fat (a 10.3% decrease) (P = .01); a reduction in weight of 2.3 kg (P<.001); and a decrease of 0.10 mmol/L (3.8 mg/dL) in low-density lipoprotein cholesterol level (P = .10). Average time for the initial counseling intervention in group 3 was 8.2 minutes, 5.5 minutes more than in the control group. CONCLUSION: Brief supported physician nutrition counseling can produce beneficial changes in diet, weight, and blood lipids.

Adult↗
PubMed1984

Facial pattern differences in long-faced children and adults.

Vertical facial morphology has traditionally been studied by examining subjects chosen because of open bite/overbite or mandibular plane angle. The underlying skeletal and dental morphology associated with clinical facial appearance of normal and vertically dysplastic children and adults has not been well documented. The purposes of this study were to (1) describe vertical facial morphology in long-, normal-, and short-faced children and long-faced and normal adults, and (2) identify morphologic factors associated with the clinical evaluation of long-faced and normal subjects. Forty-two children, 6 to 12 years old, and forty-two young adults with varied vertical facial types were examined clinically and separated into three vertical classifications: long, normal, or short face. Lateral cephalometric radiographs were obtained in natural head position and seven angular, eighteen linear, and six ratio measurements were made. Descriptive statistics were used to characterize all groups, and intergroup differences were compared using analysis of variance for the three child groups and the t test for the two adult groups. For both long-faced children and adults, anterior total face height, mandibular plane angle, gonial angle, and mandibulopalatal plane angle were significantly greater than normal. Ramus height was not significantly different from normal in the children, but there was a tendency for long-faced adults to have short rami. Excessive dentoalveolar development was evident in long-faced children but not in adults. Factors associated with the clinical identification of vertical dysplastic subjects were identified by a principal component analysis. For each component, a variable highly correlated with that component was selected.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

Accuracy of cancer death certificates and its effect on cancer mortality statistics.

A study to determine the accuracy of cancer mortality data was done using cancer deaths occurring during 1970 and 1971 in eight of the nine areas included in the Third National Cancer Survey (TNCS). Death certificates with an underlying cause of death of cancer were compared to the hospital diagnosis for 48,826 resident cases of single primary cancers. The underlying cause of death as coded on the death certificate was found to be accurate for about 65 per cent of the cancer deaths in this study. Misclassification problems occurred for colorectal cancer, the second leading cause of death from cancer. Colon cancer was overreported and rectal cancer was under-reported on death certificates. Other misclassification problems were found for cancers of the uterus, brain, and buccal cavity including most of its sub-sites. Physicians tended to report a non-specific site of cancer on the death certificate rather than the specific site identified by the hospital diagnosis.

Autopsy↗
PubMedDate not supplied

Comparison of visual estimate with digital caliper measurement of coronary artery stenosis.

We compared visual estimate and digital caliper measurement of coronary stenoses, utilizing both a 50% and 70% diameter reduction as a definition of significance and both experienced angiographers and cardiology fellows as readers. Ten angiograms were interpreted twice, using the different methods, by four readers, two months apart. The angiograms were divided into 12 vessel segments. Stenoses were judged more severe by visual estimate in 11 segments. Seven of twelve segments had significant differences between readers using the visual estimate, but no significant differences were obtained using caliper measurements. Variability was highest for fellows using the visual method. Interobserver agreement was highest using the digital caliper and the 70% criteria. Intraobserver agreement was most dependent on the amount of time taken in film interpretation. The digital caliper appears to be preferable in interpreting angiograms, particularly for cardiology fellows.

Coronary Angiography↗