[Imitation of nature in form and color].
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Biomedical subjects
Publications and source records attributed to E Steger.
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Swelling, monomer production, polymerization and frictional qualities of test samples of Palocos E, Palacos R and Paladon 65 (Messrs Kulzer & Co, Bad Homburg) have been examined in order to establish which of these plastic substances would be most suitable for replacement of small joints. We found that samples of Palacos E, hardened under pressure of 3.0 kp, had the most favorable qualities.
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Cold polymerizates "Kallocryl K" and "Palacos" were characterized by means of physico-chemical methods of examination. The residual monomer content of the polymerizates, which is of major toxicological interest, was also determined quantitatively. It was possible to show that the residual monomer content decreases exponentially as a function of the duration of polymerization. "Palacos" polymerizates had much higher residual monomer contents than "Kallocryl K" polymerizates when the same time of polymerization was used. Also discussed in this paper are possible methods of reducing the residual monomer content prior to implantation of the plastic materials.
Positive clinical results were obtained using implanted cold polymerizates, and these were compared with the negative results of experiments made on animals. The observed local pathophysiological processes are considered to be due to the effects produced by the methacrylic methyl ester. The absolute content of residual monomers in the implants does not allow to make any definite conclusions as to the rate of diffusion into the organism. Therefore, the diffusion of residual monomers into an aqueous medium was titrimetrically measured for three weeks by the pyridine sulfate dibromide method. After a description of the method of titration and the results obtained, a discussion is given of the causes of the different rates of diffusion of residual monomers from Kallokryl K and Palacos samples, which are dependent upon the duration of polymerization in air.