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Biomedical subjects

E Stetter

Publications and source records attributed to E Stetter.

9 recordsLinked to original sources

Multiple-spin-echo imaging with a 2D Fourier method.

In 2D Fourier imaging the normal Carr-Purcell multiple-echo sequence generally leads to center line and mirror artifacts caused by imperfect rotations by the rf pulses. We describe a method to avoid these distortions using a phase alternating-phase shift (PHAPS) sequence which also allows multiple-slice and multiple-echo imaging at the same time. Measuring phantoms with calibrated T2 values, we have shown that the PHAPS imaging sequence leads to an accuracy of quantitative T2 determinations of better than 10%. Contrast-enhanced images are presented which we calculated from multiple-echo images and extrapolated to arbitrary echotimes, including negative ones. We believe that these improvements in T2 imaging will result in a significant reduction of patient investigation time in magnetic resonance imaging.

Fourier Analysis

Magnetic resonance imaging of aneurysms and thrombi.

This is a report of the first systematic investigation of the qualitative and quantitative diagnosis of aneurysms in the regions of the left ventricle and thoracic and abdominal aorta plus proof of intracavitary thrombi in the heart and the aorta, as well as aneurysms in the superior and inferior vena cava. For diagnosis of the heart, ECG gating is an absolute necessity, but for the analysis of abdominal aortic aneurysms it only leads to a considerable improvement of the spatial resolution. For differential diagnosis of the blood flow and intracavitary clots in the heart and the aorta, use of a second or even multiple echoes is needed. Also, digital subtraction between the first and second echoes (magnetic resonance digital subtraction) can assist in assessing flow. When dissecting aortic aneurysm is suspected and in cases when risk of perforation of ventricular and aortic aneurysms is present. MR offers particular advantages, since it is noninvasive and few scans can provide all the information that is required.

Aged

[ECG-triggered NMR-tomography of the heart. Pathological findings].

Initial systematic examinations of the heart by ECG-triggered NMR are reported. Twenty-three abnormal findings were observed amongst 46 patients examined. Special indications are the search for cardiac aneurysms, intracardiac thrombi and changes from pressure and volume stress.

Coronary Disease

[ECG-triggered NMR tomography of the heart].

The technique and scope of ECG-triggered NMR tomography of the heart are described. Correct attachment of the ECG electrodes and cables is important in order to avoid artifacts. The anatomical structure of the heart and mediastinum can be demonstrated with a clarity which has not been possible hitherto in all three planes (axial, frontal, sagittal). This results in considerable advantages when examining abnormal hearts, since it is possible to avoid the risk of contrast media.

Electrocardiography

[Clinicoradiologic significance of different study parameters in NMR tomography of the abdomen].

One hundred and nine patients have been examined with NMR tomography, including 44 examinations of the abdomen. In 35 cases, different sequences were used. In 28 patients it was possible to determine the relaxation times T1 and T2. Pathological processes showed not only different T1 and T2 values, but also different pictorial contrast. In order to extract the maximum amount of information, it is necessary to carry out NMR tomography with varying sequences.

Abdominal Neoplasms

[Experience with NMR tomography of the skeletal system].

The value of nuclear magnetic resonance (NMR) tomography in the skeleton is analysed in 27 patients who had been examined by a prototype NMR scanner (resistive magnet, 0.2 Tesla). Anatomical structures and detail can be seen using the spin-echo mode and brief sequences. There is marked contrast difference between normal and abnormal tissues. Pathological changes lead to marked alterations in relaxation times. Inflammatory conditions, tumours and aseptic bone necrosis are demonstrated with a high degree of sensitivity. Tomography in the three geometric planes, with any desired additional plane, shows the extent and localisation of bone abnormalities.

Adolescent

Nuclear magnetic resonance (NMR) tomography of the central nervous system: comparison of two imaging sequences.

A brief description of a nuclear magnetic resonance (NMR) imaging system and preliminary results from its clinical evaluation in the study of various central nervous system diseases are presented. Particular attention is paid to NMR capabilities for soft tissue discrimination, topographical demarcation, and specificity of diagnosis. Two imaging sequences were used: (a) Spin echo measurements with four sets of imaging parameters revealed the different appearances of normal and pathological structures. (b) Inversion recovery images showed marked gray-white matter contrast and clear depiction of pathological lesions. Finally, a number of measurements of longitudinal (T1) and transverse (T2) relaxation times of normal and pathological tissues were carried out.

Adult

The diagnostic value of morphology and relaxation times in NMR-imaging of the body.

NMR examinations were performed on a total of 109 patients using a resistive magnet. In 67 patients various organs and tissues of the face and neck the trunk and the limbs were evaluated in axial, sagittal and coronal planes. The use of more than one sequence time is essential for adequate representation of the anatomical structures and for detection and evaluation of pathological processes. They are the base to compute "secondary" T1- and T2-images, in order to obtain numerical values of both relaxation times. Thus a better understanding of the morphology of structures within the images is obtained. NMR appears to represent a sensitive method of tissue characterization: Specific changes in the T1- and the T2-pattern were found in pathological conditions, e.g. longer T1-times with normal or moderately longer T2-times in tumors compared to healthy tissue and extremely long T1- and T2-times typical of fluid accumulations.

Abdomen