Biomedical subjects

E Stokić

Publications and source records attributed to E Stokić.

10 recordsLinked to original sources

PubMed1996

[Epidemiologic analysis of emergency conditions in the diabetic population as observed in the work of emergency medical services in the area of Novi Sad].

The authors analyzed a group of 236 diabetic patients in the municipality of Novi Sad who asked for the help of the Emergency medical service of the Health Center "Novi Sad". A special emergency team which manages vitally endangered patients acted on their requests. After anamnestic data were gathered and physical examination done, electrocardiographic monitoring was performed. Glycemia was determined from semiquantitative analysis of the capillary blood, while glycosuria and acetonuria from urine. In regard to these patients the gathered results point to predominant presence of chronic, degenerative complications, especially of the cardiovascular apparatus. However, this was the case due to the fact that these were elderly persons (62.78 +/- 12.21 years of age) suffering from diabetes mellitus for about 8 years, which is sufficient for development of chronic, degenerative complications of diabetes. Although the studied group was metabolically unregulated (glycemia: 18.13 +/- 5.43 mmol/l, glycosuria positive in 4.54%, acetonuria in 2.20% of patients) there were no elements for diagnosis of some acute metabolic complications. The decrease of acute metabolic complications may be connected to better organization of the antidiabetic service in the municipality of Novi Sad. It is especially important to point out the occurrence of serious hypoglycemias caused by oral hypoglycemics (64.28%) which require, according to contemporary approach, a long-term hospital treatment.

Adolescent↗

PubMed1996

[The role and significance of sagittal abdominal diameter in the determination of adipose tissue distribution].

Up-to-now trials have pointed out the importance of determining the type of obesity because the central type of obesity is joined with glucose tolerance disturbance, hyperinsulinemia and insulin resistance. The sagittal abdominal diameter proved to be the method of choice in routine clinical practice for visceral fat tissue detection. We examined a group of 60 females in whom, apart from standard measures (body weight, height, body mass index, perimeters of waist and hips), the sagittal abdominal diameter was measured by means of specially constructed caliper (Holtain Kahn Abdominal Caliper). Gathered parameters were compared with the results of an examination performed on 30 healthy females of normal body weight (control group). Results show a statistically significant higher sagittal abdominal diameter in females with central type of obesity in comparison to the control group, which points to greater quantity of visceral fat tissue in this type of obesity.

Abdomen↗

PubMed1996

[Relation between the abdominal sagittal diameter, fat tissue distribution and metabolic complications].

Numerous epidemiological and clinical studies point to association of android type of obesity with metabolic complications, such as glyco-regulation, hyperlipoproteinemia, accelerated atherosclerosis which all lead to cardiovascular diseases. As the waist-hip ratio did not prove to be specific enough for determining association between fat tissue distribution and risk from development of obesity complications, measurement of the sagittal abdominal diameter has been established. Studies carried out up to now reveal that there is a better connection between these measurements and obesity complications. A group of 45 women was examined: 30 obese and 15 healthy non-obese women being the control group. The following was measured: body height, body weight, waist and hip circumferences, blood pressure, body mass index (BMI), waist-hip ratio (WHR) and a special caliper was used to measure the sagittal abdominal diameter. In order to study glyco-regulation all obese women underwent GTT (Glucose tolerance test) with determination of insulinemia; in regard to lipidic parameters total cholesterol, high-density lipoproteins (HDL) and low-density lipoproteins (LDL) cholesterol and index of atherosclerosis were determined. Gathered results show that in the group of obese women values of sagittal abdominal diameter were significantly higher than in the control group, while metabolic parameters show that in these patients there is a metabolism disorder of lipids and lipoproteins as well as hyperinsulinemia and reactive hyperinsulinemia and higher values of systolic and diastolic blood pressure. Our results of examination in the group of android obese women show that there is a significant association among values of sagittal abdominal diameter and lipid disorders, disorders of glycoregulation, especially hyperinsulinism and insulin resistance.

Abdomen↗

PubMed1992

[Hypophyseal pseudomacroadenoma in primary hypothyroidism--2 case reports].

Primary hypothyroidism is often accompanied with hyperprolactinemia and if the untreated disease persists longer hypophyseal adenoma consisting of thyreotropic cells might develop. On the other hand, although rarely, simultaneous occurrence of primary hypothyroidism and hypophyseal prolactin adenoma might be encountered. If substitutional therapy, after the establishment of euthyroid status, does not eliminate clinical signs of hyperprolactinemia and normalize prolactin levels, a decision can be made in favor of hyperprolactinemia within primary hypothyroidism. In that case possible tumor changes in the hypophysis will show regressive tendency towards final disappearance. However if clinical signs and hyperprolactinemia persist after the establishment of euthyroid status, especially if accompanied with compressive signs this should be regarded as a coincidence of primary hypothyroidism and hypophyseal prolactin tumor. We report two female patients with primary hypothyroidism and hypophyseal pseudomacroadenoma.

Adult↗

PubMed1992

[Psychological characteristics of obese persons with special reference to periods of modified fasting].

It is well known fact that the results of modified fasting can be improved if the basic therapeutic method is combined with psychotherapeutic procedures. We have analyzed the data taken by a poll from 55 extremely obese women treated by modified fasting regimen. The results absolutely justify the above mentioned remark that radical reduction cures may cause critical moments most frequently recognized in hunger crisis when patients feel a need for conversion with medical staff. With no doubt, any help from a qualified person might be perfectly beneficial. Besides, obese persons are more inclined to depressive moods which may aggravate during these cures. In order to maintain the achieved result for a longer period of time if not for good, a continuous team work which include psychotherapeutic measures is of special significance. On the highest level it would be smart to establish an association of treated obese people, which would be a link between a patient and a professional.

Adult↗

PubMed1992

[The metabolic X syndrome--4 case reports].

The study reviews current knowledge about metabolic X syndrome characterized by android obesity, arterial hypertension, insulin resistance with hyperinsulinemia and disturbed carbohydrate tolerance, a decrease of HDL cholesterol and an increase of the triglyceride rich VLDL particle level. The study describes 4 female patients having been diagnosed for this syndrome. Only an ontime and vigorous reduction of overweight, along with intensified physical activity can prevent later development of serious complications, first of all, in cardiovascular system.

Adult↗

PubMed1990

[Case report of pheochromocytoma with an atypical localization].

One of the endocrine causes of arterial hypertension is pheochromocytoma, usually located in the adrenal gland medulla. Extra-adrenal tumor locations are seldom encountered, and this can considerably complicate the diagnostic procedure. If a distinct clinical manifestation exists, supported by the finding of elevated catecholamine values, it is essential to persistently and carefully search for the place of their increased production. Such an attitude is completely justified in regard to the knowledge that this endocrinologically conditioned hypertension can be permanently and successfully solved with a surgical procedure. A case of pheochromocytoma has been presented with an atypical mediastinal location, prolonged and complicated diagnostic procedure, which has been successfully solved by surgery.

Adult↗

PubMed1990

[Drug therapy of obesity--results of treatment with dexfenfluramine].

The paper presents the results of treatment in 22 obese persons with hypoenergetical nutrition of 4200 kJ with the simultaneous application of dexfenfluoramine in the daily dose of 30 mg in the course of three months. During this period of time an average weight loss of 7.5 kg was achieved, and a loss of 10 kg and more in one third of the patients. The controlled laboratory parameters did not show any significant deviations, and side effects in the form of mouth dryness and diarrhea were rare, and of a lighter intensity so that they did not demand the stop of therapy. When correctly indicated, dexfenfluoramine presents a valuable supplement in the therapeutic arsenal for obesity treatment, because thanks to its anorexigenic effect it eases the conducting of hypoenergetical nutrition and improves the treatment effect of this pathological condition.

Adult↗

PubMedDate not supplied

[Prolactin secretion in hyperthyroid individuals].

Several endocrine and metabolic changes occur in hyperthyroidism, among which also changes in prolactin secretion are present. Causes are numerous. However, a decreased content of prolactin in secretory granules of the lactotrophic cells in the adeno-hypophysis gland, e.i. a decreased prolactin pool, should be especially emphasized. Prolactin secretion of the adeno-hypophysis gland was examined in 30 hyperthyroid patients. Normoprolacinaemia was diagnosed in basal conditions, but prolactin response was not so great during stimulation tests (test with thyrotropic hormone and eglonylic test) and suppression tests (L-DOPA and bromo-cryptic test). This finding suggests the existence of a decreased prolactin pool in hyperthyroidism.

Adolescent↗

PubMedDate not supplied

[Hyperinsulinemia as a key factor in the development of many metabolic disorders].

Insulin resistance and consequent hyperinsulinemia present a frequent disorder and according to some investigations it is present in a quarter of whole population. Leaving aside numerous genetic syndromes caused by pronounced insulin resistance, this paper surveys the influence of specific arrangement of fat tissue in the development of this disorder, its role in insulin-independent form of diabetes, development of lipidic and lipoproteinic disorders, in the essential arterial hypertension, and finally, in the appearance of accelerated and premature atherosclerosis. Further intensive investigations of this problem will probably result in achieving a definite explanation of the importance of hyperinsulinemia as a marker of cardiovascular risk.

Arteriosclerosis↗