Biomedical subjects
Publications and source records attributed to E Stolević.
A 35-year-old female patient with oligomenorrhoea had a deletion of the long arm of the X chromosome. The breakpoint at band q23 caused infertility in spite of excessive pituitary stimulation. The aberrant X chromosome was inactivated in all cells analysed.
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A structural X chromosome abnormality was found in the karyotype of a tall patient with gonadal dysgenesis and with no extragenital anomalies. Based on her mother's karyotype, which showed a pericentric inversion of the X chromosome: 46,X,inv(X)(p22q24), as well as from G and R banding, we concluded that the abnormal X chromosome of our patient was a recombinant chromosome that had originated as a result of one crossing over in the inversion loop during gametogenesis in her mother. The recombinant X chromosome had a partial delection of Xq and a partial duplication of Xp: 46,X,rec(S),dup p,inv(X)(p22q24). After BUDR incorporation, the abnormal X chromosome of the patient and that of her mother showed a late replication. The karyotype-phenotype correlation and the nonrandom inactivation of the inverted X chromosome in the mother are discussed.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The author sets forth most recent views of the role of the cervical factor in the process of conception, of the composition of the cervical secretion, the mechanism of the elimination of the secretion, the sperm transport, secretory changes under the influence of hormones, and the part played by cervical crypts in the whole process. It is pointed out that in the assessment of the cervical factor in the development of infertility, the distributed sperm transport itself is already a disease of the cervix.
Antibodies against spermatozoids can prevent the passage of of spermatozoids through the cervical mucus in the in vitro penetration test. Statistically significant negative correlations were observed between spermoagglutinizing antibodies, spermoimmobilizing antibodies, and the penetration capacity of spermatozoids through the cervical mucus, which means that the spermoimmobilizing activities of the agglutinizing serum might have been responsible for the diminished penetration of spermatozoids.