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Biomedical subjects

E Stranden

Publications and source records attributed to E Stranden.

At least 73 records · Page 4Linked to original sources
PubMed1983

Transcapillary forces in patients with lower limb ischemia.

Starling pressures (interstitial fluid pressure, plasma and interstitial fluid colloid osmotic pressures) were measured in subcutaneous tissue at the ankle in 20 healthy controls and 27 patients with lower limb atherosclerosis. Subcutaneous interstitial fluid pressure (Pif) of the leg was also measured in seven patients with arterial emboli of the lower limb. Interstitial fluid was collected by implantation of nylon wicks and Pif was measured by the 'wick-in-needle', technique. The calculated reabsorption pressure (equal to capillary pressure if no net filtration occurs) was 18.3 mmHg in the group with atherosclerosis, which was higher than in controls (15.8 mmHg, P less than 0.05). Colloid osmotic pressure of interstitial fluid (COPif) was significantly lower in patients with atherosclerosis than in controls (5.9 v. 9.2 mmHg). This finding in itself could make those patients more susceptible to edema formation postoperatively. On the other hand, there was no correlation between COPif and ankle systolic blood pressure within the group of patients. There was a slight, but statistically significant positive correlation between ankle systolic blood pressure and Pif in patients with lower limb atherosclerosis although mean Pif was not different from controls (-1.0 v. -0.8 mmHg). In patients with arterial emboli, however, Pif was lower (mean -4.5 mmHg).

Adolescent↗
PubMed1983

Transcapillary forces in subcutaneous tissue of patients following operation for lower limb atherosclerosis.

Colloid osmotic pressure in plasma (COPpl) and in interstitial fluid (COPif) was measured in 18 healthy controls and 38 patients with leg oedema following femoropopliteal arterial reconstruction. Interstitial fluid was collected from nylon wicks which had been implanted subcutaneously for 1 h. Interstitial fluid pressure was measured with the 'wick-in-needle' technique. The patients were examined once in the period 1-16 days after surgery. Twenty-three had oedema at the time of examination. Nearly all recordings of patients with oedema were performed 4-16 days postoperatively. Mean increase in leg volume in patients with oedema was 20%. Mean COPif of the operated extremity were 5.4, 6.8 and 7.5 mmHg in the periods 1-3, 4-7 and 8-16 days after surgery, respectively. These values were lower than in controls (9.3 mmHg, P less than 0.05). Mean COPif in the operated leg was 1.2 mmHg lower than in the contralateral leg of patients without oedema. In patients with moderate oedema (less than 15% leg volume increase) this difference was approximately three times higher. For more extensive oedema the difference declined, and above 20% leg volume increase, COPif of nearly all legs operated on was higher than the contralateral. This probably reflects an increased transcapillary fluid filtration in patients with moderate oedema whereas lymphatic obstruction due to the surgical procedure is the main causative factor in patients with extensive oedema. Compared to the contralateral leg, mean increases in Pif of the leg operated on were 0.6, 2.3 and 3.6 mmHg in the three investigation periods respectively. Pif in operated legs in the two last periods was also higher than in controls (-0.7 mmHg, P less than 0.005). Increased Pif may thus contribute towards limiting oedema formation postoperatively.

Adolescent↗
PubMed1982

Treatment of Raynaud's phenomenon with the 5-HT2-receptor antagonist ketanserin.

The selective 5-hydroxytryptamine2-(5-HT2)-receptor-blocking agent ketanserin was given in a dose of 10 mg intravenously to nine patients with Raynaud's phenomenon. The effect on blood flow was assessed by photopletysmography and measurments of skin temperature. Digital blood flow and skin temperature increased significantly after ketanserin injection, whereas the placebo (saline 9 g/l) had no such effect. This study suggests that ketanserin may be useful in the treatment of Raynaud's phenomenon.

Adult↗
PubMed1982

Radon daughter equilibrium and unattached fraction in mine atmospheres.

Measurements of the equilibrium between radon and its daughters in mine atmospheres are presented. The situation in mines seems to be too complex to be described by any simple theoretical model. There is however a good correlation between the equilibrium factor, F, and the individual daughter ratios. This suggests that the individual daughter concentrations may be assessed by Kusnetz-measurements of the equilibrium factor, F. Measurements by the wire screen method indicate that the dust concentration is the main influencing factor upon the unattached fraction of the radon daughters. The unattached fraction of the potential alpha-energy was lower than 0.05 in most mining situations. In areas with very clean air, the unattached fraction may however be higher than 0.3. Measurements indicated a good correlation between the unattached fraction of the potential alpha-energy and the unattached fraction of the individual daughter products. This suggests that assessments of the unattached fraction of the individual daughters may be obtained by using the Kusnetz method for measurements on the screen and back up filter.

Air Pollution, Radioactive↗
PubMed1982

Lymphatic and transcapillary forces in patients with edema following operation for lower limb atherosclerosis.

Intralymphatic end pressure and Starling pressures (interstitial fluid pressure (Pif), plasma and interstitial fluid colloid osmotic pressures (COPpl and COPif)) were measured in leg subcutaneous tissue in 5 patients with local leg edema following femoropopliteal reconstruction for lower limb atherosclerosis. Superficial lymphatics were cannulated proximal to the ankle and the catheter was connected to either syringes for determination of lymph flow and colloid osmotic pressure (COPl), or to a pressure transducer for measurement of intralymphatic end pressure. Samples of interstitial fluid were collected by implantation of nylon wicks and Pif was measured by the "wick-in-needle" technique. In all patients normal end pressure waves with maximum values ranging between 30 and 40 mmHg were recorded, indicating that the ischemia prior to surgery had not significantly affected the intrinsic mechanism for lymph propulsion. COPif of the operated leg averaged 5.7 mmHg +/- 1.0 which was 0.9 mmHg +/- 0.7 higher than the corresponding COPl. This supports the theory of "preferential channels" between the capillaries and the lymphatics. There was a statistically significant correlation between lymph flow and estimated capillary pressure (reabsorption pressure), capillary filtration coefficient, calf blood flow and Pif. According to this study the capillary pressure should at least be 11 mmHg before production of lymph occurs.

Aged↗