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Biomedical subjects

E Streicher

Publications and source records attributed to E Streicher.

15 recordsLinked to original sources
PubMed1979

[Haemofiltration in terminal renal failure (author's transl)].

The concentrations of low-molecular retention products rise during long-term haemodialysis, without any apparent side effects. The authors, having performed haemofiltration in 18 patients who had been on a chronic dialysis programme, conclude that haemofiltration is generally better tolerated than conventional haemodialysis. Haemofiltration benefitted the majority of dialysis-resistant hypertensives, and it also favourably influenced uraemic polyneuropathy. Indications for haemofiltration are thought to be dialysis-resistant hypertension, severe polyneuropathy, and dialysis intolerance.

Female↗
PubMed1979

Haemofiltration - critical evaluation of clinical benefits.

To delineate the worth of chronic HF in end stage renal failure, since 1976 we have treated 9 patients with dialysis-resistant hypertension, 6 patients with dialysis intolerance, 7 patients with hypertriglyceridaemia and 7 patients with polyneuropathy. We found an improvement of polyneuropathy and volume-sodium dependent hypertension and symptoms of dialysis discomfort markedly diminished. No amelioration was detected in anaemia, hypertriglyceridaemia and volume-independent hypertension. Hyperphosphataemia was poorly controlled despite increased amounts of aluminium hydroxide. PTH values increased and renal osteopathy seemed to deteriorate.

Acidosis↗
PubMed1978

Thyroid function in long term haemofiltration.

Ten patients on haemofiltration treatment for between 4 and 20 months have been screened for thyroid function. Comparing serum T3 and T4 levels at the start of haemofiltration and 5 to 20 months later, a continuous decrease was detected (T3-Ria: 92 +/- 23 ng% to 68 +/- 23 ng%; T4-Ria: 4.94 +/- 1.79 microgram% to 3.81 +/- 1.21 microgram%). Serum TSH-Ria values also declined in mean from 3.48 +/- 0.47 muU/ml, yet two patients showed an increase as expected with a functioning hypothalamic pituitary-thyroid axis. During a single treatment TBG, T4 and T3 values increased in excess of the amount expected for the degree of blood volume contraction, whereas the T4/TBG ratio remained normal indicating peripheral euthyroidism. Serum TSH was found to decrease significantly after 5 hours of haemofiltration possibly by losses via the haemofiltrate. Stimulation of the pituitary gland by i.v. injection of 200 microgram TRH gave a normal TSH response. Chronic haemofiltration leads to a proportional decline of thyroid hormones and their protein bound fractions: euthryoidism was proved by the normal T4/TBG ratio and the absence of clinical signs of hypothyroidism.

Humans↗
PubMed1978

Does long term haemofiltration provoke secondary hyperparathyroidism?

One thousand nine hundred and forty-nine haemofiltration procedures have been performed since 1976; 4 different types of haemofilters have been tested in gravimetric and volumetric haemofiltration machines. Balance studies revealed a diminished calcium intake of about 1/3 of that found in conventional dialysis. Magnesium balance is negative and leads to decreasing serum Mg values. Inorganic phosphate is removed in similar quantity to dialysis. PTH levels increase during 3--18 months of treatment, whereas 25-OH-D3 levels rapidly fell, gc-globulin- and HCT-levels did not change markedly. g-c globulin could be detected in filtrate samples in remarkable amounts, 25-OH-D3 was found in traces. Radiologically no apparent alteration occurred. We recommend Vitamin D supplementation to compensate for the losses and thereby avoid development of secondary hyperparathyroidism.

Calcium↗
PubMed1977

Capillary membranes for hemofiltration.

Membranes for hemofiltration were manufactured from blood-compatible polyamides in the form of capillaries. Hemofiltration units containing these capillaries were tested in vitro with aqueous solutions of salts and metabolites and with whole human blood. The results show that the capillary membranes fulfill the requirements for a membrane suitable for hemofiltration.

Biocompatible Materials↗
PubMed1977

Asymmetric polyamide hollow-fiber filters in the hemofiltration system.

We tested the asymmetric polyamide hollow fiber as the filter in the hemofiltration unit. Effective membrane thickness was 1mu, the diameter of the hollow fiber was 600mu, and the total surface was 1 m2. Membrane cutoff was determined at 13,000 daltons molecular weight. A fully automated system was used to replace the volume of ultrafiltrate with a balanced electrolyte solution. Clearance rates for BUN, creatinine, uric acid, and inorganic phosphate were calculated at 70-75 ml/min when prediluting (i.e., when balanced electrolyte solution is admitted to the arterial line of the extracorporeal circuit). Clearance rate for inulin was determined at 23 ml/min. Sieving coefficients for small molecular weight solutes were determined at 1.0 and for inulin 0.4. This decrease is explained by the development of a secondary protein layer and by unflavorable streaming conditions inside the hollow fiber. The ultrafiltrate remained free of protein.

Kidneys, Artificial↗