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E Strong

Publications and source records attributed to E Strong.

30 records · Page 2Linked to original sources
PubMed1981

Stability of oxygen transmissibility during ischemia.

Simultaneous measurements of oxygen availability (O2a) and partial pressure (PO2) were made by the double noble metal electrode system designed by Erdmann and Krell in an attempt to monitor the oxygen transmissibility (Dk) with respect to time before and after ischemic episodes in the brain cortex. Available current equations can appropriately describe the performance of the electrode in a homogeneous nonconsuming medium, and with some experimental error this electrode system can be used to estimate oxygen transmissibility changes in the brain based on the different characteristics of the O2a (rod-type, flush-ended bare tip) and the PO2 (rod-type, recessed tip) cathodes. Our method monitors the oxygen transmissibility within the diffusion sphere of the bare tip as the ratio of the currents related to O2a and PO2. We find with this system that even prolonged global cerebral ischemia does not alter the oxygen transmissibility of the brain tissue. Therefore, alternation of the oxygen transmissibility can not be a contributing factor to postischemic cerebral malfunction.

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PubMedDate not supplied

Effects of ischemia on the oxygen diffusion coefficients in the brain cortex (studies on Macaca irus).

In this series of experiments changes in oxygen diffusion coefficients were measured in waking primates undergoing focal middle cerebral artery ischemia; Ligation of the middle cerebral artery followed by a decrease of the oxygen diffusion coefficient in the areas supplied by that vessel to levels ten to twenty per cent below normal by twenty-five minutes following onset of ischemia. Following release and re-perfusion diffusion coefficient gradually increases and reaches a super normal peak value three hours after release of ligation. This is followed by a gradual reduction in diffusion coefficient with stabilization at preocclusion levels. In the three experiments described these changes following re-perfusion corresponded with clinical improvement of the neurological status of the monkeys;

Animals↗
PubMedDate not supplied

cis-Dichlorodiammineplatinum(II)-based chemotherapy as initial treatment of advanced head and neck cancer.

During the past 2--3 years, a total of 73 patients with advanced head and neck cancer (mostly stage IV) were treated with cis-dichlorodiammineplatinum(II) (cis-platinum) as initial therapy, either alone or in combination with other agents. After chemotherapy, the patients received surgery and/or radiation therapy in standard fashion. Major degrees of tumor regression were seen in 40%--71% of the patients. cis-Platinum and bleomycin given by infusion gave the highest response rate (71%). The addition of high-dose methotrexate to cis-platinum plus bleomycin produced an unacceptable level of toxicity. Similarly, a four-drug regimen in which low-dose methotrexate and vinblastine were added to cis-platinum and bleomycin resulted in increased toxicity without additional therapeutic effect. Initial chemotherapy does not compromise subsequent surgery or increase either the immediate complications of surgery or the acute toxicity of radiation therapy. It seems unlikely that initial chemotherapy has altered the grim prognosis of an advanced, inoperable presentation. The effect of initial chemotherapy on advanced, operable disease will have to be assessed by suitable controlled trials.

Antineoplastic Agents↗