Intracellular receptors and signal transducers and activators of transcription superfamilies: novel targets for small-molecule drug discovery.
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Biomedical subjects
Publications and source records attributed to E T Jones.
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The selection of fusion levels in thoracic idiopathic scoliosis was subjected to multicenter retrospective review to test the validity of the classification system and recommendations of King et al. The 253 patients reviewed were treated by posterior fusion and Harrington instrumentation. Bending films were of little help in selecting fusion levels. Standing radiographs alone were usually adequate. King Type II curves may yield better lumbar correction if the lumbar curve is partially included in the fusion. Type IV curves may be safely fused one level proximal to the stable vertebrae.
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Fifty consecutive patients had posterior spinal fusion using only graft from bone banks. They were studied retrospectively in order to determine the pseudarthrosis rate, the quality of fusion mass obtained, the rate of infection, volume of blood lost, and operative time. The results showed that it is likely that the graft material used is not as important as the fusion technique. Strict adherence to facet obliteration, posterior element decortication, thorough removal of all soft tissue, and stable, well-planned instrumentation are probably the most important factors in preventing pseudarthrosis. With the complications associated with iliac crest graft and the potential benefits of reduced operative time and blood loss, use of allogeneic bone appears justified.
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During surgical correction of scoliosis, 63 patients had somatosensory evoked potential (SEP) monitoring of the spinal cord. Tibial nerves were unilaterally stimulated, and the potentials were recorded from the midcervical spine with surface and epidural needle electrodes. Over 85% had no significant change in their SEP and no postoperative neurologic deficits. Eleven percent had a significant change in their potential (amplitude decrease of greater than 60% and/or latency increase of greater than 2.5 msec) with no neurologic complications. One patient had a significant potential change and temporary postoperative sensory deficits did occur. One additional patient experienced postoperative neurologic complications but had no SEP change. This single false negative case, however, was clinically significant only for motor dysfunction, which is not monitored by the SEP. When changes in patient core temperature were compared to changes in SEP amplitude and latency, an intraoperative decrease in core temperature increased SEP latency and decreased amplitude, which may explain in part the false positive rate of the procedure.
For all lower extremity problems in children with cerebral palsy, early attention to overactive spastic muscle groups can aid in preventing bony deformities under most situations. More severely involved children need more aggressive treatment, with early soft tissue procedures to attempt balance of muscle groups surrounding joints. Early aggressive management of soft tissue problems can avoid long-term bony deformity and more severe posturing problems in the lower extremities of children with cerebral palsy.
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Infantile cortical hyperostosis (Caffey-Silverman syndrome) is an uncommon and not well-understood disorder. Most authors confine cortical hyperostosis strictly to infants under six months of age as originally described by Caffey. Others indicate they have seen the same clinical, radiographic, and pathologic problem in older children as initial presentations or as a recurrence where the infantile phase had possibly been unrecognized. This is a report of idiopathic cortical hyperostosis (ICH) in an 11-year-old girl who had no history of the disorder as an infant. The report confirms others who have documented cortical hyperostosis in older children and postulates that it is the same entity as infantile cortical hyperostosis.
Intraoperative awakening is commonly used to evaluate voluntary motor function to lessen the risks of nerve damage during posterior spine fusion and Harrington rod instrumentation for idiopathic scoliosis. This is a report of intraoperative monitoring of tension in the soft tissues of patients with idiopathic scoliosis utilizing a strain-gauged distraction outrigger. The tension in soft tissues was found to drop following intraoperative awakening by an average of 52 N in the 14 patients monitored. The "wake-up" technique may aid in protecting the spinal cord from overdistraction by the increase in soft tissue tension present at the time of Harrington rod replacement in addition to providing a spot check of motor function. This increased tension may slightly repress curve correction.
The use of the computed tomography has been rapidly expanding in the 7 years it has been clinically available, and there is no doubt that this modality will have an important role in the assessment of many pediatric orthopedic problems. Computed tomography now provides previously unavailable information in cases of tumors, infections, and fractures of the axial skeleton, pelvis, and hips. With the faster scan times, better density and two-point resolution of the newer generation scanners, computed tomography will be useful in other isolated cases and in more situations, but still may not gain wide applicability in pediatric orthopedics.
This is a case presentation of an occurrence of a C2--C3 dislocation without fracture occurring in a child, probably at the time of birth, causing weakness and hypotonia and going unrecognized for almost 2 years. Surgical stabilization provided a slow improvement in neurologic function. Cervical spine injury should be an initial diagnostic consideration in the newborn with hypotonia ("congenital myopathies" and "floppy infants"), since discovery of remediable lesions early could make stabilization therapy effective.
We retrospectively reviewed the use of computed tomography scans for the preoperative evaluation of musculoskeletal neoplasms in nineteen children. Of twenty-five scans, there was accurate correlation with the surgical findings in thirteen patients (fourteen scans), while overestimation or underestimation of the extent of soft-tissue disease was evident in nine patients (eleven scans). We concluded that computed tomography is a useful adjunct to the more conventional means of preoperative assessment but that overdependence on this one method of evaluation should be avoided.