PubMed Health⌕ Search

Biomedical subjects

E T Martin

Publications and source records attributed to E T Martin.

10 recordsLinked to original sources
PubMed2004

Myocardial first-pass perfusion magnetic resonance imaging: a multicenter dose-ranging study.

BACKGROUND: MRI can identify patients with obstructive coronary artery disease by imaging the left ventricular myocardium during a first-pass contrast bolus in the presence and absence of pharmacologically induced myocardial hyperemia. The purpose of this multicenter dose-ranging study was to determine the minimally efficacious dose of gadopentetate dimeglumine injection (Magnevist Injection; Berlex Laboratories) for detecting obstructive coronary artery disease. METHOD AND RESULTS: A total of 99 patients scheduled for coronary artery catheterization as part of their clinical evaluation were enrolled in this study. Patients were randomized to 1 of 3 doses of gadopentate dimeglumine: 0.05, 0.10, or 0.15 mmol/kg. First-pass perfusion imaging was performed during hyperemia (induced by a 4-minute infusion of adenosine at a rate of 140 microg x kg(-1) x min(-1)) and then again in the absence of adenosine with otherwise identical imaging parameters and the same contrast dose. Perfusion defects were evaluated subjectively by 4 blinded reviewers. Receiver-operating curve analysis showed that the areas under the receiver-operating curve were 0.90, 0.72, and 0.83 for the low-, medium-, and high-contrast doses, respectively, compared with quantitative coronary angiography (diameter stenosis > or =70%). For the low-dose group, mean sensitivity was 93+/-0%, mean specificity was 75+/-7%, and mean accuracy was 85+/-3%. CONCLUSIONS: First-pass perfusion MRI is a safe and accurate test for identifying patients with obstructive coronary artery disease. A low dose of 0.05 mmol/kg gadopentetate dimeglumine is at least as efficacious as higher doses.

Adenosine↗
PubMed1998

Imaging cardiac structure and pump function.

This article describes magnetic resonance imaging approaches for assessing cardiac structure and myocardial pump function. The article is divided into cardiac structure and ventricular function. Throughout, representative images are included. There are numerous applications of magnetic resonance imaging for assessing cardiac structure and function, and magnetic resonance imaging compared favorably to other imaging modalities.

Heart↗
PubMed1996

Development of space motion sickness in a ground-based human centrifuge.

Adaptation of the vestibular system, specifically the otolith organs, to a non-terrestrial environment can result in space motion sickness-like symptoms when the human is reintroduced to the normal, 1 Gz, terrestrial environment. This premise was investigated by exposing nine subjects to 90 min of sustained 2 Gz acceleration in a human centrifuge and then observing and evaluating them at 1 Gz. Five of the subjects developed slight SMS symptoms, three developed moderate, and one developed frank sickness. Postural instabilities in two of the most affected subjects were also observed using the Equitest System post exposure. Long duration exposure to a non-terrestrial G(2Gz) appears to be a potential means for developing SMS-like symptoms in a ground-based human centrifuge.

Adaptation, Physiological↗
PubMed1989

Recurrent tonsillitis: histologic and bacteriologic evaluation.

Histologic and bacteriologic evaluations of tonsils removed at surgery from ten patients with a diagnosis of recurrent tonsillitis were performed. The bacteriology was complex, with an average of 6.3 aerobic bacteria and 3.3 anaerobic bacteria isolated from each patient. Histologic sections revealed chronic cryptitis, with intact tonsillar architecture. These findings provide a possible explanation for the failure of commonly used antibiotic regimens to eradicate recurrent infection from this site.

Adolescent↗
PubMed1985

Clinical evaluation of the Lumac bioluminescence method for screening urine specimens.

A bioluminescence method for screening urine cultures to provide rapid reporting of negative specimens and to select appropriate urine cultures for direct application of automated identification methods was evaluated. A total of 2,000 specimens were processed in the Lumac Biocounter (3M, St. Paul, Minn.), and the results were compared with quantitative culture techniques by using a 0.001-ml inoculating loop. A total of 841 specimens were positive by the bioluminescence method; 291 specimens were culture positive (greater than or equal to 50,000 CFU of one or two organisms per ml). Positive cultures represented more than 20 different organisms. Approximately two-thirds of the false-positive results represented mixed flora or pure cultures of less than 5 X 10(4) organisms per ml. The predictive value of a negative result was 98.4%, reflecting a false-negative rate of only 0.7%. No advantages in cost or technician time were noted, but the Lumac method appears to be a useful technique in decreasing reporting time, especially for negative urine cultures.

Bacteriuria↗
PubMed1984

Sudden unexpected death as a result of anomalous origin of the right coronary artery from the left sinus of Valsalva.

The association of sudden unexpected death with coronary artery anomalies has been limited to cases of anomalous origin of the left main coronary artery, either from the right sinus of Valsalva or from the main pulmonary artery. In contrast, anomalies involving the origin of the right coronary artery have been considered to be benign. Postmortem examination in a patient who died suddenly at 23 years of age disclosed that the right coronary artery originated anomalously from the left sinus of Valsalva. The findings in this patient: (1) constitute the first necropsy documentation of premature sudden unexpected death in a patient whose sole pathologic abnormality was anomalous origin of the right coronary artery; (2) have important implications regarding previously proposed mechanisms of sudden death due to anomalous origin of the left main coronary artery; and (3) support recent suggestions that markedly acute angulation of either coronary artery, even when located in the appropriate sinus of Valsalva, may predispose to sudden unexpected death.

Adult↗
PubMed1975

Intragranular starch: comparison of starch USP and modified cornstarch.

Incorporation of starch USP or a modified cornstarch within the granules of several drug formulations was investigated. In general, the formulation containing the modified starch exhibited improved processing characteristics as well as improved tablet properties. A comparison of a granulated and a direct compression formulation of the same ingradients indicated that granulation of an active ingredient is not necessarily detrimental to its (pharmaceutical) availability.

Acetaminophen↗