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Biomedical subjects

E T Owen

Publications and source records attributed to E T Owen.

At least 19 recordsLinked to original sources
PubMed1994

Scleromyxoedema associated with synovitis and myopathy.

Scleromyxoedema is a rare skin disease characterized by the deposition of hyaluronic acid in the papillary dermis and often associated with the presence of a monoclonal para protein. Patients with this disorder may also have systemic manifestations. A case of a patient with biopsy proven scleromyxoedema who, in addition to the skin changes had a steroid responsive myopathy and polysynovitis is presented.

Carpal Tunnel Syndrome↗
PubMed1987

Unusual paraspinal muscle lesions in ankylosing spondylitis.

Minicore, multicore, core-targetoid and other ultrastructural lesions were found in the paraspinal muscles of patients with AS. The 10 patients studied, all men with AS, showed varying degrees of muscle fibre atrophy, Z band streaming, rod body formation, minicores, multicores and core-targetoid fibres. Central core disease, rod body myopathy, minicore and multicore diseases are recognized clinical entities within the congenital group of structural myopathies. Target fibres are believed to be a feature of reinnervation. It is also known that experimental tenotomy causes core-targetoid changes, rod bodies, minicores and multicores. Therefore, it seems possible that tension is a necessary stimulus for the correct programming of synthetic muscle enzymes, and without this disorganization occurs. It may also be assumed, but in this case for genetic reasons, that similar biochemical systems are disturbed in the group of congenital myopathies.

Adult↗
PubMed1986

Cardiac rheumatoid nodules.

Rheumatoid nodules in the heart are unusual specific manifestations of rheumatoid arthritis. This paper describes three cases in which these nodules were found at necropsy. The patients were women with long histories of rheumatoid arthritis, two of whom had significant but unexplained congestive cardiac failure. The rheumatoid nodules were present in the patients' myocardium and in one patient's pericardium. We suggest that in patients with rheumatoid arthritis with severe but unexplained cardiac failure, the possibility of rheumatoid nodules in the heart should be considered.

Aged↗
PubMed1984

Eosinophilia in rheumatoid patients treated with D-penicillamine.

The prevalence of eosinophilia in 66 patients with rheumatoid arthritis receiving D-penicillamine was determined in a retrospective study. Eosinophilia occurred in 24%. The simultaneous occurrence of toxicity and eosinophilia occurred in 3%. In contrast, eosinophilia only occurred in 10% of those with suspected toxicity. The value of eosinophilia as a marker of toxicity is discussed.

Adult↗
PubMed1983

Observer variation in grading sacroiliac radiographs in HLA-B27 positive individuals.

This study attempts to reconcile the apparent differences in the reported frequency of ankylosing spondylitis and radiological sacroiliitis in HLA-B27 positive individuals. Pelvic radiographs from 125 Busselton subjects were mixed with 81 other films selected to illustrate the possible range of sacroiliac changes and were graded by observers who were involved in 2 of the conflicting studies and by a 3rd independent observer. Concordance was high for advanced bilateral disease but not for unilateral and milder changes. Variation between observers and the interpretation of sacroiliac radiographs is sufficiently large to account for much of the disagreement between frequency estimates.

Arthritis↗
PubMed1983

Prevalence of eosinophilia during gold therapy for rheumatoid arthritis.

The prevalence of eosinophilia in 82 rheumatoid arthritis patients receiving gold sodium thiomalate (GSTM) and 30 patients receiving auranofin (AF) was determined in a retrospective study. Eosinophilia occurred in 21% taking GSTM and in 13% on AF. The simultaneous occurrence of toxicity and eosinophilia occurred in 14% receiving GSTM and in 10% receiving AF. In contrast, eosinophilia only occurred in 24% of those with suspected toxicity receiving GSTM and in 30% of those with suspected toxicity receiving AF. The value of eosinophilia as a marker of toxicity is discussed.

Adult↗
PubMed1982

Reactive arthritis associated with Clostridium difficile.

A case of reactive arthritis in a patient with a previously documented history of Reiter's syndrome is described. The precipitating agent appears to have been Clostridium difficile. High levels of toxin were demonstrable in the faeces and neutralising antitoxin was detected in the patient's serum but not synovial fluid. Resolution of the polyarthropathy was slow despite successful eradication of the C. difficile with a course of vancomycin.

Adult↗
PubMed1979

Methotrexate in Reiter's disease.

Three cases of severe Reiter's disease were treated successfully with methotrexate after failure of conservative therapy, including systemic corticosteroids in 2 instances. The usefulness and potential hazards of such therapy are discussed, and some evidence that corticosteroids may aggravate the dermatological manifestations of Reiter's disease is presented.

Adolescent↗
PubMed1979

Clinical significance of antibodies to ribonucleoprotein.

Antibodies to ribonucleoprotein (RNP) were detected by an immunofluorescence technique based on the sensitivity of speckled antinuclear antibodies to ribonuclease. These antibodies were found to identify a group of patients with a consistent set of clinical features, especially arthritis, swollen hands, Raynaud's phenomenon, and myositis. The presence of anti-RNP antibodies in sera from patients with polymyositis, systemic lupus erythematosus, and systemic sclerosis was also associated with these clinical features. Other studies of the clinical significance of these antibodies support the concept that they appear to identify a group of patients with a distinct clinical condition.

Adolescent↗
PubMed1977

Symptoms and signs among relatives of patients with HLA B27 ankylosing spondylitis: Correlation between back pain, spinal movement, sacroilitis, and HLA antigens.

In order to determine the prevalence of ankylosing spondylitis and the prevalence and pattern of back pain amongst the relatives of patients with ankylosing spondylitis, 63 first degree relatives of 14 propositi were assessed by means of questionnaire, physical examination, and radiology. There were no significant differences in the responses of the B27 positive and negative relatives in relation to prevalence, severity and character of back pain. Ankylosing spondylitis was found in 6.5 per cent of B27 positive relatives and 3.1 per cent of B27 negative relatives; sacroilitis being present in 12.9 per cent of B27 positive relatives and 6.3 per cent of B27 negative relatives. A family studied is presented as a possible corssover between HLA B locus and disease "predisposition" genes. It is suggested patterns of back pain may not be as discriminating as has been thought.

Adolescent↗