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Biomedical subjects

E Taleporos

Publications and source records attributed to E Taleporos.

5 recordsLinked to original sources
PubMed1979

Outcomes of pregnancy for addicts receiving comprehensive care.

This study reports pregnancy outcomes for 105 addicted women enrolled in New York Medical College's Pregnant Addicts and Addicted Mothers Program. Three classes of variables are examined: prenatal care variables, obstetrical outcomes, and neonatal outcomes. As a first step, percentage distributions are shown for all variables within each class. With respect to the second and third classes, comparisons are made when possible to findings reported elsewhere on heroin-addicted, methadone-maintained, and drug-free populations. Zero-order correlations are then shown for the prenatal care variables versus the neonatal outcomes. It is found that the mother's number of prenatal medical visits correlates significantly with the neonate's gestational age at birth and birth weight, and that her methadone dose at time of delivery correlates significantly with the neonate's withdrawal status. The effect of the prenatal care variables on the two key neonatal outcomes--gestional age at birth and birth weight--is then examined via a stepwise regression analysis. It is found that two of the variables--gestional duration at first prenatal visit and number of prenatal visits--together account for 18.5% of the variance in birth weight and 26.9% of the variance in gestational age at birth, while maternal methadone dose has virtually no effect on these outcome measures. The findings indicate that better neonatal outcomes are associated with the mother's joining the program relatively early in pregnancy and coming in relatively often for prenatal care.

Adult↗
PubMed1978

The neuroleptic hypothesis: study of the covariation of extrapyramidal and therapeutic drug effects.

A therapeutic trial with chlorpromazine was conducted with a homogeneous (for age and sex) group of recently admitted schizophrenic patients. Extrapyramidal effects were measured through quantitative analysis of digital tremor, after four days of fixed-dose treatment. Assessment of treatment efficacy was based on Brief Psychiatric Rating Scale ratings, done at the end of four weeks' treatment. Those patients whose tremor was least affected by drug were most likely to benefit from the treatment. Implications of this negative correlation for our understanding of the neuroleptic hypothesis and the closely associated dopamine hypothesis of schizophrenia are discussed.

Adolescent↗
PubMed1978

Naltrexone and conventionality.

This study examines the effect of conventionality on whether patients who were scheduled for naltrexone took it, and on treatment outcomes for patients who did take it. It is based on admission and case record data for 147 male opiate addicts who enrolled in New York Medical College's Multitrack Abstinence Program. Naltrexone-taking is examined against an array of "drug" and "social" variables and is found to be strongly related to four in particular: amount spent daily on heroin, number of arrests, type of residence, and employment. These variables are combined into an index which measures a patient's degree of conventionality. It is found that naltrexone-taking varies directly with degree of conventionality. Furthermore, it is found that, among patients who took naltrexone, those who gained in conventionality while in treatment were more likely than others to leave the program opiate-free after terminating naltrexone therapy.

Adolescent↗