Biomedical subjects
Publications and source records attributed to E Tanner.
The 12-year experiences of a working team with the intraarticular radiogold therapy in persisting synovialitides of chronic rheumatic diseases and resistant irritation phases of arthroses are supplementarily described and a critical valuation is performed. Finally practical conclusions for the local joint therapy are made, taking into consideration also the experiences of other investigators.
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The diagnosis of carpal-tunnel syndrome was made clinically in 124 cases (101 patients) and in each instance it was confirmed by nerve-conduction studies. Surgery was carried out with a uniform technique. Retrospective analysis of the series suggests that nerve-conduction studies can be used as a prognostic factor. Those patients with motor abnormalities appeared to have a more favorable result than those with only sensory abnormalities. Neurolysis was found to be a valuable adjunct to the release of the volar carpal ligament. Preoperative duration of symptoms did not appear to significantly influence the results of the operation.
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Together with gastroenterologists rheumatologists describe diagnostically significant disturbances of the supporting apparatus and the locomotor system which frequently occur in ulcerous colitis, enterocolitis regionalis Crohn, Whipple's disease and non-tropical sprue. Important conclusion for the diagnostic approach supplement the description.
To investigate whether steroids influence the course and prognosis of acute sarcoidosis (Löfgren syndrome) 35 patients who developed this disease during the period 1960-1970 were examined and retrospectively divided into two groups, one of which had received steroids and the other not. At the onset of the disease all the patients had had typical symptoms of acute sarcoidosis: bilateral hilar lymphadenopathy, erythema nodosum, arthralgia, fever and elevated sedimentation rate. Biopsy of hilar lymphnodes had revealed non-caseating granulomas in all cases, whereas such granulomas were present in only 7 of 15 liver biopsies. The Kveim reaction was positive in 89% and the tuberculin skin test was negative in 51%. The duration of the disease was 6-7 weeks in both groups, i.e. steroid treated and non-steroid treated. The radiological chest abnormality had usually disappeared within one year. All chest X-rays had completely normalized after two years. Neither the course nor the prognosis differed in the two groups. However, patients receiving steroids had had more side effects. Acute sarcoidosis should not be treated with steroids; symptomatic therapy with other, less toxic antiinflammatory drugs suffices. The outcome is good. None of the patients has progressed to chronic sarcoidosis.
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It is reported on the therapeutic effects with trenimon in patients with rheumatoid arthritis half a year and one year after the end of the treatment. When critically judged the quota of success was 32.5% for the total judgement after half a year. Significant relations dosis-effect could be ascertained only for the parameters of clinical activity up to 1 year and humoral inflammatory signs after half a year. When the therapeutic success is assessed in any case the additional therapeutic expenditure must be taken into consideration. Before the beginning of the therapy there was no ascertained relation between success of therapy and duration of the disease, sex, age, activity and function.