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Biomedical subjects

E Taskinen

Publications and source records attributed to E Taskinen.

At least 73 records · Page 4Linked to original sources
PubMed1977

Nitrofurantoin-induced alterations in pulmonary tissue. A report on five patients with acute or subacute reactions.

Three patients with acute and two with subacute nitrofarantoin-induced pulmonary reactions were studied clinically and by examinining microcoscopically needle biopsy specimens of their lungs. In all five patients slight vasculitis and a few interstitial eosinophils were found in the pulmonary tissue 1-2 weeks after the withdrawal of nitrofurantion therapy. Alveolitis, fibrinous alveolar exudate and perivascular granulomas were also seen in some specimens. The patients with acute reactions had marked blood eosinophilia. In all patients, pulmonary diffusing capacity (DLCO) was below normal, but ventilatory function was not appreciably affected. Withdrawal of nitrofurantion resulted in complete or partial improvement in 4-8 weeks. Our clinical and histological findings support the suggestion that a type III immune-complex-mediated reactions is involved in acute and subacute hypersensitivity reactions to nitrofurantoin.

Adult↗
PubMed1975

Radiology and fine needle aspiration biopsy in the diagnosis of tumours of the kidney.

The value of angiography and fine needle aspiration biopsy in detecting, grading and staging of renal tumours was studied in 55 patients with renal tumours suspected clinically or on urography. 42 patients had malignant tumours. A correct angiographic diagnosis was made in 94% of the renal adenocarcinomas, the corresponding percentage for the aspiration biopsies was 71%. A combination of angiography and cytologic examination gave the correct diagnosis in 97%. In 4 cases of renal pelvic carcinoma the angiography showed extensive hydronephrosis only, the final diagnosis in these was cases achieved by fine needle aspiration biopsy. Angiographic staging of 30 renal adenocarcinomas was made according to the TNM system. The radiological staging was correct in 30% of T3 tumours, but in only 50% of T1 tumours and in one out of five T2 tumours. The difficulties seemed to be in determining the relation of tumours situated marginally near the renal capsule. Angiographic grading of the tumour was made according to the vascular pattern and the time of venous filling. Sparse vascularity and venous filling time of over 5 seconds was found in highly differentiated carcinomas and abundant vascularity and fast venous filling in neoplasms of moderate or low differentiation. The cytologic grading correlated fairly well with the histological grading. This study shows that angiography combine with fine needle aspiration biopsy provides good facilities for obtaining a correct diagnosis in renal tumours and preoperative information of the extent and degree of differentiation of renal malignant tumours.

Adenocarcinoma↗
PubMed1974

Differential cellular increase in cerebrospinal fluid after encephalography in mentally retarded patients.

The behaviour of the CSF cells during gas encephalography (GEG) with O(2), N(2)O, and halothane is poorly known in cerebral developmental disorders. One hundred and fifty CSF samples taken during pneumoencephalography from 75 mentally retarded patients were examined cytologically by the millipore technique with Papanicolaou staining. The results were processed automatically. An approximately 25-fold increase in CSF cells (P<0·001), mainly meningeal, reticulohistiocytic, and monocytic types, was found to occur. The cortical gas filling rate had a positive correlation (P<0·001) with the increase of number of CSF cells. There were no significant differences between the cellular changes in different cerebral disorders. Thus, though the irritant effect of GEG gives a rich cell yield, diagnostic atypical cells in developmental disorders of the central nervous system probably rarely exfoliate into the lumbar CSF.

Adolescent↗