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Biomedical subjects

E Tawil

Publications and source records attributed to E Tawil.

At least 19 recordsLinked to original sources
PubMed1985

Hodgkin's disease complicating pregnancy.

We report our experience in the management of 12 patients with Hodgkin's disease associated with pregnancy. Three patients presented in the first trimester; pregnancy was interrupted in two. They are alive and well after 8, 14 and 16 years of follow-up. Two patients presented in the second trimester; they elected to continue their pregnancies and both died from progressive disease, one of them having refused therapy. The remaining seven patients in the third trimester continued pregnancy; they are all alive after five to 11 years of follow-up and one is alive with active disease. Two patients received radiotherapy during pregnancy. Both had normal outcomes of pregnancy and no fetal abnormalities were found. There is no evidence to suggest that either pregnancy affects the course of Hodgkin's disease or that Hodgkin's disease affects pregnancy. General rules as to how to proceed in patients with Hodgkin's disease complicated by pregnancy are described.

Adult↗
PubMed1984

[Laparotomy in Hodgkin's disease: significance of splenic involvement].

We retrospectively reviewed 224 cases of Hodgkin's disease, in 120 of which staging laparotomy was performed. The surgical findings in cases of clinical stage I or II disease with supradiaphragmatic presentation or clinical stage III disease did not influence the treatment plans. Of the 64 patients with positive results of laparotomy (splenic or lymph node involvement or both) 51 had splenic involvement; their 5-year survival rate, 57%, was similar to that of the patients with clinical or pathological stage III disease - 58% and 54% respectively. At laparotomy 11 patients with pathological stage III disease were found to have isolated splenic involvement; their 5-year survival rate, 64%, was not appreciably different from that of the patients with clinical stage II disease, 70%; both groups were treated with radiotherapy only. From this study we can conclude that splenic involvement in Hodgkin's disease has no deleterious effect on survival and that splenic irradiation seems to be as effective as splenectomy in controlling the disease.

Combined Modality Therapy↗
PubMed1983

Acute graft-versus-host disease after allogeneic bone marrow transplantation.

In 25 patients receiving allogeneic bone marrow transplants methotrexate was used to prevent acute graft-versus-host disease (GVHD). Acute GVHD, grades 2 to 4, developed in only 5 (20%) of the patients. The incidence of acute GVHD in other series of recipients of bone marrow transplants has ranged from 5% to 76%. A review of the literature suggests that this variation cannot be completely accounted for by age, type of disease treated by transplantation or type of GVHD prophylaxis. However, transfusion of allogeneic lymphocytes that have not been completely inactivated by irradiation (e.g., in platelet and granulocyte preparations) and inadequate isolation-decontamination procedures may increase the probability of GVHD following bone marrow transplantation.

Acute Disease↗
PubMed1983

Restoration of normal hematopoiesis by bone marrow ablation and allogeneic marrow transplantation in a case of Hodgkin's disease therapy-related preleukemia.

Therapy-related leukemias are generally preceded by a preleukemic phase of several months duration, characterized by pancytopenia, abnormal bone marrow findings, and nonrandom chromosomal abnormalities in almost all cases. No specific therapeutic guidelines are recommended in this preleukemic phase or any other type of preleukemia; aggressive combination chemotherapy is usually withheld until the full expression of leukemia. A 22-yr-old man with therapy-related preleukemia following treatment of Hodgkin's disease received as primary treatment ablative chemotherapy followed by marrow transplantation from his histocompatible sister. At day 316, the patient is still in complete bone marrow recovery with a normal donor karyotype. In the light of the very poor results obtained with conventional chemotherapy regimens once the leukemic phase is established, we suggest that bone marrow transplantation, if undertaken before leukemic conversion, may be the treatment of choice in young adults with therapy-related preleukemia.

Adult↗
PubMed1983

Second malignancy complicating Hodgkin's disease.

We have reviewed the records of 227 patients with Hodgkin's disease diagnosed between 1969 and 1977 inclusively. The incidence of a second malignancy has been assessed. Fourteen patients developed second malignancies, 10 of which were solid tumors and four acute leukemias. The ratios of observed to expected malignancies were assessed for three subgroups: it was 1.58 for patients who received radiotherapy alone, 5.17 for patients who received combined radiotherapy and chemotherapy, and 14.73 for a third subgroup of patients who also received maintenance chemotherapy. A detailed analysis of the 14 patients with a second malignancy has been done. Only one occurred in a patient who had had a splenectomy. Patients who had a relapse of Hodgkin's disease did not have an increased incidence of second malignancy. Treatment-induced malignancies appear to be rather aggressive. Of the 14 patients, 12 died within one year and two are alive with disease, one year after diagnosis.

Acute Disease↗
PubMed1975

[Anaplastic epithelioma of the thyroid gland 6 years after cervical irradiation for malignant lymphoma].

Carcinoma of the thyroid gland may develop after irradiation of the cervical region. It is well documented in patients who received radiation therapy to the neck in childhood but rarely when the therapy was given in adulthood. A case of an undifferentiated carcinoma of the thyroid gland occurring in an adult 6 years after irradiation of the cervical region for a malignant lymphoma is reported. The role of irradiation and the factors related to the development of carcinoma of the thyroid gland are reviewed.

Age Factors↗
PubMed1975

Malignant lymphoma of the testis.

Three cases of patients suffering from malignant lymphoma of the testicle are reported. The clinical aspects and characteristic pathological features are discussed. The evolution of lymphoma of the testicle differs from lymphomas in other sites and appears to be more agressive. It is recommended that a more extensive radiation therapy be applied because of frequent extra-nodal spread which is often excluded when using conventional fields. Chemotherapy provides long periods of remission in malignant lymphoma. This therapeutic weapon should be combined with radiation therapy for a better control of the disease.

Aged↗
PubMed1974

Malignant testicular tumours.

A series of 71 patients with malignant testicular tumours treated primarily by orchiectomy and irradiation is reviewed with respect to pathological and clinical features and modes of treatment.The three-year crude survival rate in 36 patients with seminoma was 86% and in 24 patients with carcinoma it was 41.7%. There were no survivors among patients with choriocarcinoma. Our results are comparable with those of other series.A prospective study is proposed of the value of irradiation and subsequent limited lymph node dissection following orchiectomy in cases of carcinoma of the testis.

Adolescent↗