Confidentiality and research.
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Confidentiality↗
Biomedical subjects
E Theis
Publications and source records attributed to E Theis.
Influence of treatment time on the response of rat rhabdomyosarcoma R1H to fractionated irradiation.
The aim of this work was to study influence of overall treatment time on response of an experimental tumour to fractionated radiotherapy. Rhabdomyosarcoma R1H of the rat was treated by fractionated irradiation applying 30 fractions in different overall treatment times of 10, 18.5, 29, 39, and 67 days. The doses per fraction ranged from 1.50 to 2.67 Gy. Tumour response was assessed by net growth delay and by an in vitro colony assay. The results indicate that repopulation of the tumour with clonogenic tumour cells slowed down during treatment leading to an average doubling time of clonogenic tumour cells of 8 +/- 1 days, which is considerably longer than that of unirradiated tumours (3 days). The repopulation rate seemed to increase after about 3 weeks of treatment with a doubling time of tumour clonogens of 5 +/- 1 days, which was still lower than in control tumours.
Animals↗
Hepatocellular carcinoma: pilot trial of treatment with Y-90 microspheres.
The potential use of yttrium-90 glass microspheres in the treatment of hepatocellular carcinoma was assessed in a pilot study of seven patients. The Y-90 microspheres were injected via a hepatic artery catheter. In this group of patients, no toxicity was observed for absorbed doses of between 5,000 and 10,000 cGy to the liver and up to 32,000 cGy to the tumor itself. Tumor response was seen only at the higher absorbed doses. The new Y-90 glass microspheres can safely deliver large doses of internal radiation to hepatic tumors as long as extrahepatic shunting can be excluded. Extrahepatic shunting will be the main limitation to this form of radiation therapy.
Brachytherapy↗