PubMed Health⌕ Search

Biomedical subjects

E Theodor

Publications and source records attributed to E Theodor.

68 records · Page 4Linked to original sources
PubMed1968

Treatment of ulcerative colitis with azathioprine.

Azathioprine (Imuran) was administered to seven patients with ulcerative colitis suffering from a relapse which could not be controlled by adrenocortical steroids. In four patients remission started one to two weeks after initiation of antimetabolite therapy. Corticosteroid administration was continued concurrently with azathioprine, but the dosage could be reduced and in one case they were withdrawn.Apart from transient leucopenia in two cases, and transient nausea and vomiting in two, no complications were encountered.

Adolescent↗
PubMed1967

Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man.

The absorption of cholesterol has been studied in man by perfusing the upper jejunum with a micellar solution of bile salt, 1-monoglyceride, and cholesterol-(14)C, with a triple lumen tube with collection sites 50 cm apart. The absorption of micellar components between the collection sites was calculated from their concentration changes relative to those of the watersoluble marker, polyethylene glycol. Control experiments were performed with cholesterol-free perfusions of saline or bile salt-monoglyceride solutions. Steady state conditions were obtained.Each of the components of the micelle was absorbed to a different extent during passage through the test segment of jejunum. Bile salt was not absorbed (mean, -3%), but micellar monoglyceride was rapidly hydrolyzed and absorbed almost completely (mean, 98%). Cholesterol radioactivity was absorbed to an intermediate extent (mean, 73%), and the absorption of chemically determined cholesterol (mean, 46%) indicated that much of the disappearance of radioactivity represented true absorption and not simple exchange. The specific activity of the perfused cholesterol fell during passage through the loop. This fall was interpreted as signifying the continuous addition of nonradioactive endogenous cholesterol by the test segment. However, the decrease in specific activity may also be considered to signify exchange, in that nonradioactive molecules entered the lumen as radioactive molecules were absorbed. Plant sterols appeared in the intestinal contents during the perfusion and must have been contributed by the perfused segment. The perfusate and samples taken from the upper and lower collection sites were examined by ultracentrifugation to define the physical state of cholesterol. It was found that cholesterol in the perfusate or upper collection site samples did not sediment, but that 23% of the cholesterol in the lower collection site samples was sedimentable (mean of three experiments); bile salt, as control, was not sedimentable. Solubility experiments in model systems showed that cholesterol possessed low solubility in bile salt solution; its solubility increased markedly and in linear proportion to the amount of fatty acid or monoglyceride or both that was added to the bile salt solution. These findings suggest that polar lipid such as fatty acid or monoglyceride as well as bile salt is essential for normal micellar solubilization of cholesterol in intestinal content. They suggest the necessity of considering an insoluble sedimentable phase of particulate sterol in intestinal content as well as an oil and micellar phase for a complete description of sterol absorption. The marked difference in the rates of absorption of individual micellar components suggests that micellar lipid is not absorbed as an intact aggregate and is consistent with the view that polar lipid such as fatty acid is absorbed in molecular form by diffusion from a micellar solution. The experiments confirm previous findings demonstrating that fat absorption without bile salt absorption occurs in the upper small intestine in man.

Adult↗
PubMedDate not supplied

Asymptomatic liver injury due to erythromycin stearate.

A 73-year-old woman with rosacea, who had started treatment with erythromycin stearate 2 g/d, developed asymptomatic liver injury. The drug was discontinued and the laboratory findings of liver damage disappeared within 11 days. This is the first report of erythromycin stearate-induced asymptomatic hepatotoxicity.

Aged↗
PubMedDate not supplied

Hydralazine-induced hepatitis in pregnancy.

During 1983, 38 patients with pregnancy-induced hypertension were treated with hydralazine-apresoline (1-hydrazinophthalazine). During the course of their treatment, five of these patients showed evidence of the HELLP syndrome described by Weinstein (hemolysis, thrombocytopenia, and elevated liver enzymes). Evidence is presented on the role of hydralazine in producing hepatocellular damage. Liver function is compromised during the natural course of pregnancy-induced hypertension, and 5-10% of preeclamptic patients develop the HELLP syndrome. In many places hydralazine is the drug of choice in the treatment of pregnancy-induced hypertension.

Chemical and Drug Induced Liver Injury↗
PubMedDate not supplied

Anti-Rnp antibodies in chronic liver diseases.

Antinuclear antibodies are commonly observed in chronic liver disorders. Sera from 87 patients with various chronic liver diseases were tested for the presence of antibodies against two extractable nuclear antigens (ENA) - RNP and Sm. Using an enzyme-linked immunosorbent assay (ELISA) anti-RNP antibodies were detected in 13 patients (15%) most of whom had cryptogenic or primary biliary cirrhosis. When the sera were further tested by ELISA for the presence of anti-Sm antibodies no antibody binding could be detected. These findings support the notion that anti-RNP (but not anti-Sm) antibodies are included among the autoantibodies shared by systemic lupus erythematosus and chronic liver diseases.

Autoantibodies↗