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Biomedical subjects

E Till

Publications and source records attributed to E Till.

8 recordsLinked to original sources
PubMed1992

[Serotonin syndrome--a case account].

Beside a large number of pharmaceuticals available on our market having an impact on serotonergic transmission, selective serotonin reuptake blocker inhibitors (fluvoxamine, fluoxetine) and a selective reversible monoaminooxidase inhibitor (moclobemide), have been included recently. The combination of the drugs can in certain conditions cause a central serotonergic hyperactivity, i.e. the serotonin syndrome. The study describes the development of the serotonin syndrome following an abrupt replacement of trazodone by moclobemide. The diagnosis was made on the basis of the anamnesis, clinical features, course and outcome of the disorder and diagnostic criteria suggested in the literature. The importance of the prevention, early detection and timely management of the serotonin syndrome have been reflected in the fact that some of the outcomes described were fatal, although this state most frequently remits spontaneously after the replacement of the drug therapy.

Antidepressive Agents↗
PubMed1989

Factor analytic study of depressive disorders.

Factor analysis was performed on 39 variables (symptoms and characteristics) of a diagnostically heterogenous population of depressive patients (N = 200). The results indicated the existence of one general factor that groups together "endogenomorphous" symptoms and characteristics and three others that are associated with three subtypes of depressive disorders-psychotic, anxiety, and retarded depression. The 13 variables that have high loadings with the first factor agree with widely known facts about the structure of the axial syndrome of endogenous depression.

Adult↗
PubMed1989

[The neuroleptic malignant syndrome].

Malignant neuroleptic syndrome (MNS) together with agranulocytosis represents a relatively rare but the most difficult idiosyncratic reaction to the therapy with neuroleptics. The most prominent symptoms are as follows: hyperthermia, muscular rigidity, vegetative dysfunction and disturbance in consciousness. MNS usually occurs unexpectedly and unpredictably during the first days of the treatment with neuroleptics and most frequently it takes a remarkably rapid course. About 15-20% of the cases are lethal. The aim of the successful treatment is the early recognition of MNS preferably in the prodromal phases which can by the employment of adequate therapy interfere the evolution into the full clinical picture, i.e. to the lethal outcome. Efficient therapy includes: 1) interruption in the administration of neuroleptics, 2) regulation of water disbalance and electrolyte metabolism, 3) application of drugs which activate dopaminergine transmission insufficiency (bromocriptine, predominantly) or other disturbances induced by it in other neuronal systems which is obtained by the administration of anticholinergic antiparkinsonics and benzodiazepines (GABA effect), and 4) electroconvulsion. All aspects of MNS from the standpoint of actual level of knowledge are presented in this paper. The authors' own experience with the nine MNS cases registered at their clinic is also set forth. By the improvement in diagnostic and therapy no death due to MNS has been observed over the last few years.

Adult↗