Biomedical subjects

E Tournier

Publications and source records attributed to E Tournier.

3 recordsLinked to original sources

PubMed1991

Interest of TOF PET for clinical applications.

The interest of PET is now well established in medical research. Recently PET has proved to be also useful in the clinical domain e.g. for the diagnosis of epilepsy, myocardial disease etc... Its use has been so far limited by the cost of the radionuclide production and the cost of the PET itself. However, inexpensive, compact cyclotrons and centralized distribution of F18 are beginning to facilitate the availability of radionuclides. Thanks to its performances in terms of high random rate, sensitivity gain, random reduction, TOF is becoming practical for clinical use, especially with new types of architecture allowing the reduction of the cost of the detection head, so far the main obstacle to the use of TOF PET in clinical domain.

Algorithms↗

PubMed1984

T-cell subsets in multiple sclerosis: a comparative study between cell surface antigens and function.

Pokeweed mitogen (PWM)-driven immunoglobulin synthesis (IgG, IgA, IgM) and concanavalin A (Con A)-stimulated suppression of allogeneic mixed leukocyte reaction (MLR) were studied and compared to T-cell subsets defined by monoclonal antibodies OKT4 and OKT8 in patients with multiple sclerosis (MS). The group of patients with active progressive MS showed diminished suppressor activity as measured by T-cell functional tests and also an elevated OKT4/OKT8 ratio. The group of MS patients in remission did not show these abnormalities. However, this correlation between functional tests and T-cell phenotypes was not found when separate individuals were considered within the subgroups of MS. Since neither OKT4 nor OKT8-reactive cells represent homogeneous functional subsets of T cells, the OKT4/OKT8 ratio does not account for the functional immunological status of separate individuals but rather provides a global evaluation of T-cell subset disturbances in different groups of diseases.

Adult↗

PubMed1980

Deficit of suppressor T cells in active multiple sclerosis.

Suppressor T cells in forty-seven patients with multiple sclerosis (MS) were studied by indirect immunofluorescence by means of monoclonal antibodies directed at T-cell subsets. Suppressor cell numbers were depressed in patients with acute exacerbation of MS and in patients with continuous progressive deterioration. In one case the T-cell anomaly was observed one week before the onset of the acute phase; it had been absent 4 months before exacerbation.

Acute Disease↗