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Biomedical subjects

E Trabucchi

Publications and source records attributed to E Trabucchi.

At least 55 records · Page 3Linked to original sources
PubMed1987

Transscleral contact cyclophotocoagulation with Nd:YAG laser CW: experimental study on rabbit eyes.

The authors suggest a new type of transscleral cyclophotocoagulation by using the Nd:YAG laser. This was done by bringing fibre optics into contact with the sclera. The study illustrates the macroscopic, histologic and scanning electron microscopic changes produced on the ciliary body of rabbit eyes with this technique. The actual possibility and the future prospect of applying this method to the human eye still remain to be investigated.

Animals↗
PubMed1986

Cytoprotection by PGE2, pirenzepine or vagotomy: a transmission and scanning electron microscopic study in rats.

We have studied the effects of PGE2, the anticholinergic pirenzepine and vagotomy on the rat gastric mucosa after challenge with ASA+0.15N HCl or absolute ethanol. The damage was evaluated by quantitative macroscopic examination, light and electron (transmission and scanning examinations) microscopy. We found both macroscopically and microscopically that pirenzepine and PGE2 were effective against ASA+0.15N HCl, but under microscopic examination they were seen to be uneffective 1 hr after absolute ethanol. Vagotomy showed some protection against ASA+0.15N HCl but was totally uneffective against absolute ethanol. The results stress the differences between ASA+0.15N HCl and absolute ethanol damage and show that "cytoprotection" is possible when the mucosa is challenged with noxious agents that do not act by hyperosmolar effects.

Animals↗
PubMed1986

Controlled study of the effects of tiropramide on biliary dyskinesia.

A controlled trial was carried out in patients with biliary dyskinesia to compare the effects of the new calmodulin-independent and antispastic drug tiropramide with those of imecromone. Forty patients were randomly divided into two groups, one treated with 300 mg tiropramide per day and the other with 1200 mg imecromone per day, both treatments lasting for 3 months. The results showed that tiropramide was significantly more effective in decreasing the number of attacks of pain and in improving pain and dyspepsia symptoms than imecromone. In subjects with delayed filling of the gall bladder during cholecystography, tiropramide but not imecromone was able to normalize the condition. These results confirm the antispastic synchronizing effect of tiropramide on the motor activity of the gall bladder and the sphincter of Oddi and indicate that it should be the drug of choice for treatment of motor disorders of the biliary tract.

Biliary Dyskinesia↗
PubMed1986

Topical treatment of experimental skin lesions in rats: macroscopic, microscopic and scanning electron-microscopic evaluation of the healing process.

The effects of the topical antiseptic agents mercurochrome and silver nitrate and of sodium hyaluronate on the process of wound healing were assessed by macroscopic examination, light microscopy histology, electron microscopy and scanning electron microscopy of wounds made by cutting or by abrasion of the skin of rats. It was found that wounds treated with hyaluronic acid underwent longer periods of inflammation (proportional to the presence of mastocytes) and greater amounts of collagen deposition than wounds that were either untreated controls or treated with silver nitrate or mercurochrome, but this did not impede the formation in the early stages of healing of bridges of fibrin between the edges of the wounds.

Administration, Topical↗
PubMed1986

Differential diagnosis of Crohn's disease of the colon from ulcerative colitis: ultrastructure study with the scanning electron microscope.

Mucosal biopsies from patients with Crohn's disease and with ulcerative colitis were studied by scanning electron microscopy. Important abnormalities of the mucosal surface were found in both diseases. For Crohn's disease, the characteristic abnormality was loss of the regularity of the polygonal units, but with preservation of the mucosal integrity and of the normal mucosal design. For ulcerative colitis, the abnormalities were disorganization of the cells, signs of sloughing, and superficial erosions. Patients with Crohn's disease always had a significantly increased number of muciparous cells, while those with ulcerative colitis had obvious signs of decreased mucus production. The lesions of ulcerative colitis could be seen under the scanning electron microscope in mucosal areas that appeared normal endoscopically. We feel therefore that scanning electron microscopy of biopsy specimens from patients with inflammatory bowel diseases can be of great help in differential diagnosis.

Colitis, Ulcerative↗
PubMed1985

Clinical evaluation of triletide versus antacids in the treatment of duodenal ulcer out-patients.

Thirty out-patients with endoscopically assessed, active duodenal ulcer of mild to moderate intensity were randomly assigned to 8-weeks' treatment with either antacids (0.8 g/day each of aluminium hydroxide and magnesium hydroxide), triletide (1.5 g/day) or a combination of the two treatments. Every other week, the intensity of subjective symptoms and of objective signs was scored and recorded, and the endoscopic outcome assessed at the 8th week. Three patients on antacids alone and 1 on triletide alone were withdrawn at the 4th week because of therapeutic failure. Symptoms and signs improved in the three groups significantly faster, to a significantly greater extent, and in more patients with triletide, alone or in combination, than with antacids. Endoscopic evidence of therapeutic response was detected in significantly more patients given triletide, alone or in combination, in comparison with the group who had antacids. A significant influence on promoting ulcer healing could be attributed to triletide (p less than 0.05, multiple linear regression) and not to antacids. Tolerance was complete in all patients. It is concluded that triletide appears to be equally well tolerated as, but significantly more effective than, antacids in relieving symptoms and promoting healing in patients with mild to moderate duodenal ulcer.

Adult↗
PubMed1978

[Acute hepatic failure and renal damage. Experimental and clinical studies].

Renal damage in acute hepatic failure induced in the pig by means of an hepatic state, temporary or permanent devascularisation Amanita phalloides poisoning or orthotopic liver transplant proved of slight degree, particularly in animals treated with replacement therapy. In the cases of animals that died in acute hepatic coma, on the other hand, renal cortex ischaemia and marked medullary congestion were constant. Histologically, the damage consisted of slight tubular nephrosis; this was more apparent in the proximal tubules. Evaluation of renal damage in 38 patients with acute hepatic failure was more complicated owing to the variety of clinical conditions (level of coma, hypovolaemia, intensive care and hepatic assistance). Nevertheless, a clear relation was established between the degree of liver damage and blood creatinine and creatinine clearance values. All patients who died presented liver cell necrosis of over 75%, blood creatinine values of more than 2 mg/100 ml, and less than 50 ml/min clearance. Tubular nephrosis was the predominant lesion. It appeared that renal damage was primarily pre-renal. No signs of a true hepatorenal syndrome could be made out.

Animals↗