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E Tschernoster

Publications and source records attributed to E Tschernoster.

11 recordsLinked to original sources
PubMed1993

The importance of early renal graft function.

Onset of function and consequent graft and patient survival in 7923 cadaveric kidney transplants (Tx) were analysed; 42.3% of grafts had early function, 43.6% delayed function, defined as a temporary need of dialysis postoperatively, and 14.1% grafts never functioned. Multivariate analysis of 1743 cases showed that important risk factors for delayed function were of non-immune origin, i.e. length of pre-Tx dialysis, or warm and cold ischaemia. The significant risk factors for non-functioning were of immune origin i.e. panel-reactive antibodies, DR mismatches, immunosuppression without cyclosporin A and previous Tx. Five-year survival rates of early function and delayed function grafts were identical when non-functioning grafts were excluded. Comparison of early function with delayed function grafts divided according to the length of the function delay showed worse (P < 0.05) survival in grafts with delayed function > 20 days only (50.6% grafts had delayed function < 10 days, 32.7% 10-20 days, and 16.7% > 20 days). Survival of recipients with non-functioning grafts was worse (P < 0.01) than those with early function and delayed function grafts. There was no difference in recipients' survival between early function and delayed function groups. When comparing early function and delayed function graft outcome, the problem is not so much a question of how as when to define early function. A statement that delayed function is prognostically a bad sign is not correct, as most delayed function grafts recover spontaneously without any effect on long-term graft and patient survival.(ABSTRACT TRUNCATED AT 250 WORDS)

Cyclosporine↗
PubMed1985

Hypertension rate in renal graft recipients operated on at the Transplantation Centre, IKEM, in 1976-1981.

A group of 198 renal transplantations performed et our Centre in 1976-1981 was evaluated. Arterial hypertension within the first two weeks following transplantation developed in 83% of patients, in 43% being severe. Later, towards the end of the first year, less patients suffered from arterial hypertension, especially of severe hypertension. In this period, hypertension occurred in about 63%, in most cases in the mild form (50%). Patients with graft functioning for more than a year had hypertension, mostly mild, in about 43%. The incidence of hypertension in our group was, however, increased if "normotensives" taking antihypertensives were included. We may conclude that in the first year following renal transplantation true normotensive patients formed approximately 10% of the total and their number in the subsequent years raised up to 50%. The values of blood pressure in the 3rd to 4th months had a predictive significance for the further course of hypertension. In this period, patients with hypertension had a markedly worse cumulative graft survival compared with the remaining subjects. This finding supports the importance of energetic antihypertensive therapy.

Blood Pressure↗