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Biomedical subjects

E Tuovinen

Publications and source records attributed to E Tuovinen.

At least 19 recordsLinked to original sources
PubMed1987

Low power argon laser trabeculoplasty.

Sixty-seven consecutive argon laser trabeculoplasties to as many patients were retrospectively followed-up for 3 to 12 (mean 7) months. The laser power used was substantially lower than originally proposed by Wise & Witter (1979) ranging from 100 mW to 500 mW. Factors influencing the outcome of low power trabebuloplasty were evaluated. The statistical analysis of the data was performed using multiple regression analysis, analysis of variance, t-test and chi 2-test. The mean success rate remained relatively low (33%). In the high power capsular glaucoma group it was 50%.

Aged↗
PubMed1985

Contact lenses in hypoxia.

Seven women with soft contact lenses were examined during a 4 h period in a decompression chamber. The atmospheric pressure was lowered from the normal value of 1000 millibars (750 mmHg) to 560 millibars (420 mmHg), which corresponds to the altitude of 4000 m above sea level. The humidity, temperature, percentage of carbon acid and illumination were attempted to be kept even. Five test subjects developed subjective, and all the 7 also developed objective eye symptoms. It was concluded that hypoxia itself may cause eye discomfort for aircraft passengers with contact lenses. The most serious objective findings were corneal erosions in 3 and opacities of corneal stroma in 5 test persons. The control group without contact lenses did not develop any symptoms during the test.

Adult↗
PubMed1983

[14C]6-methoxy-1,2,3,4-tetrahydro-beta-carboline in retinal and other tissues after intravascular and intravitreal injections in mice and rats.

6-Methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THBC) is a condensation product of 5-methoxytryptamine and formaldehyde. It possesses diverse biochemical and pharmacological properties and has been suggested to act as a neuromodulator. 6-MeO-THBC has been shown to occur in various tissues including the retina in animals and human beings. The present results show that the mouse and rat retina as well as other tissues take up 14C-labelled 6-MeO-THBC injected intravenously or intravitreally. The retinal concentrations show a prompt rise after the injection and significant levels are maintained after 2 days.

Animals↗
PubMed1983

Penetration of metronidazole and tinidazole into the aqueous humor in man.

500 mg of metronidazole or tinidazole were given as a 20-min infusion each to 10 patients who were hospitalized for elective cataract extraction. Metronidazole and tinidazole concentrations in aqueous humor were 5.2 +/- (SE) 0.5 and 5.3 +/- 0.7 micrograms/ml, respectively, 20-70 min after the end of the infusion. Aqueous humor/serum concentration ratios were 0.38 and 0.47 on the average for metronidazole and tinidazole, respectively.

Aged↗
PubMed1980

Clinical trial of the topical use of disodium cromoglycate in vernal, allergic and chronic conjunctivitis.

Thirty-three patients were treated with disodium cromoglycate (DSCG). Of these 5 had vernal conjunctivitis, 18 had allergic conjunctivitis and 10 had mild chronic conjunctivitis in which the exact aetiology could not be determined. 70% of patients with DSCG as the only medication achieved at least some beneficial effect being almost exclusively in the groups of either vernal or allergic conjunctivitis. The basic trend seemed to indicate a reduction in severity during the treatment with DSCG in allergic diseases.

Chronic Disease↗
PubMed1979

Uptake of taurine by platelets in retinitis pigmentosa.

Uptake of 3H-taurine by platelets from twelve patients with retinitis pigmentosa (R.P.) and from healthy controls was measured. Platelets were incubated in autologous plasma with 3H-taurine for different times and at different substrate concentrations. The uptake of taurine by R.P. platelets at each incubation time was about two-thirds of the control value, the difference being statistically significant. Km was about the same, but Vmax was lower in R.P. platelets. The results suggest that R.P. is a disease affecting not only the eye but also taurine transport and/or storage in general.

Adolescent↗