Biomedical subjects

E Turan

Publications and source records attributed to E Turan.

9 recordsLinked to original sources

PubMed1998

Effect of intratympanic steroid application on the development of experimental cholesteatoma.

By introducing certain irritants into the middle ear it is possible to produce cholesteatoma. Propylene glycol, the main agent used for this purpose, produces a long-standing inflammation that causes hyperplasia and migration of the epithelium through an intact tympanic membrane. In the present investigation topical prednisolone was used in order to inhibit the production of cholesteatoma. The results indicate that there is a marked decrease in inflammation and hence experimental cholesteatoma production when prednisolone is administered into the middle ear.

Animals↗

PubMed1998

Prognostic significance of depth of invasion in cancer of the larynx.

To determine the prognostic significance of depth of invasion in laryngeal cancer, the depth of invasion of tumor was measured with an ocular micrometer on the laryngectomy specimens of 94 surgically treated patients with T1, T2, and T3 laryngeal cancer and was expressed in millimeters. There was a significant negative correlation between the depth of invasion and disease-free survival. The tumors with no clinical involvement of regional lymph nodes in neck (NO neck) had significantly less depth of invasion than those with involvement (N+ neck). The tumors with pathologically confirmed cervical lymph node metastasis had significantly more depth of invasion than those without metastasis. For tumors with a depth of invasion equal to or greater than 3.25 mm, the rate of cervical metastasis in this study has always been significantly higher than for those with a depth of invasion less than 3.25 mm (P < .05). The mean depths of invasion for cases with and without recurrence were not significantly different. According to the multivariate analysis, depth of invasion (P = .047) and patient age (P = .113) significantly affected the disease-free survival independently. The depth of invasion did not significantly affect the recurrence and the interval between surgery and the development of recurrence (P > .15). The depth of invasion should be measured in every laryngectomy specimen. The depth of invasion influences the cervical metastasis and disease-free survival significantly but does not affect the recurrence rate. The depth of invasion plays an independent role in determining the disease-free survival.

Adult↗

PubMed1997

Jugular foramen meningioma. Report of a case and review of the literature.

The occurrence of a meningioma within the jugular foramen is very rare. We present the case of a 33-year-old man who presented with five-year history of hoarseness and was found to have paralysis of lower four cranial nerves on the left. High resolution computed tomography showed a dumbbell shaped tumor of the left jugular foramen extending intracranially over the jugular tubercle and extracranially into the parapharyngeal space. The patient underwent staged neuro-otological surgery and the mass was removed subtotally with no recurrence in six years. Histopathologic diagnosis was transitional meningioma. Our review of the literature revealed 33 previously reported cases. Four of these cases had neurofibromatosis. All but one underwent some form of otolaryngologic surgery. Although twenty had an intracranial component to their tumor, only 11 had a craniotomy. The majority of the tumors were meningothelial meningiomas (60%). Only two cases were malignant meningiomas. We reviewed the clinical and radiological characteristics and summarized the benefits and pitfalls of existing surgical options.

Adult↗

PubMed1994

Lymphoscintigraphy in pectoralis major myocutaneous flaps.

Myocutaneous flaps are used widely in the surgical treatment of advanced cancers, which in the past had been thought to be inoperable. Tumor recurrences are expected more frequently in these patients. Recurrent tumors may spread locally and to the regional areas via lymphatics and vessels. However, the lymphatic spread may differ in cases where myocutaneous flaps are used for reconstruction. This study is based on five patients with head and neck cancer who underwent reconstruction with myocutaneous flaps. Technetium Tc99m-labeled dextran was used to demonstrate the lymphatic flow, and technetium Tc99m rhenium sulfur colloid was used to show the lymph nodes of the neck and pectoralis major myocutaneous flap. Our findings show that the newly formed lymphatics do not pierce the fibrotic border of the donor and recipient sides. Lymphatic metastasis may occur to the internal mammary nodes through the myocutaneous flap only after recurrent tumors have invaded the myocutaneous flap directly.

Axilla↗

PubMed1994

Infratemporal hydatid cyst--unusual location of echinococcosis.

Hydatid disease is an important medical problem in countries of the temperate zones. Only occasional cases are reported in the head and neck region. An unusual location for hydatid disease in the infratemporal fossa is presented. Characteristics of this rare disease together with treatment modalities are discussed.

Adult↗

PubMed1991

Submandibular hydatid cyst. A case report.

An unusual case of Echinococcus cysticus infection of the submandibular salivary gland is reported. A 41-year-old female patient was admitted with a progressively increasing swelling in the left submandibular region present for two years. There was no pulmonary or hepatic involvement. The site, and that there is no evidence of pulmonary or hepatic involvement is of interest in this patient. Definitive therapy required radical surgery.

Adult↗

PubMed1987

Unusual metastases of renal cell carcinoma.

The case of a 55-year-old white male with recurrent metastases in the oral cavity and maxillary sinuses, as well as other organs, is presented. Local excision of the lesions, hormonal treatment and palliative measures for other metastases were used. The patient is alive 10 years after the initial diagnosis.

Carcinoma, Renal Cell↗

PubMedDate not supplied

Squamous cell carcinoma of the lower lip.

PURPOSE: Most patients with squamous cell carcinoma of the lower lip present with early disease and follow a rather indolent clinical course. Determinant 5-year survival rates range from 85% to 95%. This study was undertaken in an attempt to gain insight into the cause of failure in those few patients who develop recurrent disease. PATIENTS AND METHODS: A retrospective review was completed on patients treated between 1964 and 1990. Patients were staged according to the American Joint Committee. Patients with no palpable adenopathy had either a unilateral or bilateral suprahyoid dissection performed. Patients with palpable adenopathy underwent radical neck dissection. All patients were followed for evidence of recurrent disease. RESULTS: The records of 92 patients treated surgically for squamous cell carcinoma of the lower lip were available and complete. Palpable adenopathy was present in 38 patients; however, only 8 of these patients (21%) were histologically positive. Of the 54 patients judged to be free of disease, 3 (5.5%) had histologic evidence of metastasis. Overall, the incidence of cervical metastasis was 12%. CONCLUSION: The incidence of cervical metastasis in patients with squamous cell carcinoma of the lip is low; however, these data suggest that the size of the primary tumor does not correlate closely with predicting the incidence of regional lymph node metastases.

Carcinoma, Squamous Cell↗

PubMedDate not supplied

Peristomal recurrence.

INTRODUCTION: Peristomal recurrence following laryngectomy is a very serious and fatal complication. To treat this complication, extensive surgical resection has been advocated. However, when peristomal recurrence develops, the prognosis is dismal and the mortality is nearly 100%. Therefore, attention should focus on prevention. METHODS: Treatment of patients with tumors of the subglottis should include attention to the paratracheal region and superior mediastinum. For this reason pretracheal, paratracheal, and retrosternal dissection has been performed in patients with subglottic lesions since 1968 in the Otolaryngology Department of the Hacettepe Faculty of Medicine. RESULTS: The incidence of peristomal recurrence was 11.5% before 1968 in patients without pretracheal, paratracheal, and retrosternal dissection. The incidence of peristomal recurrence dropped from 11.5% to 2.7% after routine application of pretracheal, paratracheal, and mediastinal dissection in patients with subglottic lesions (either primarily or secondarily). DISCUSSION: A total of 488 patients with total laryngectomy were studied. The importance of pretracheal, paratracheal, and retrosternal dissection in patients with subglottic carcinoma of larynx (primarily or secondarily) was emphasized.

Adult↗