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Biomedical subjects

E Uchikova

Publications and source records attributed to E Uchikova.

At least 19 recordsLinked to original sources
PubMed2006

[Pregnancy in teenagers].

UNLABELLED: Teenage pregnancy is a recognized problem of social and health significance worldwide. World Health Organization considers them as high-risk pregnancies. Teenage birth rates vary by different country. OBJECTIVE: To study the frequency and the obstetric outcome of pregnancy at teenagers in University Hospital "St. George" Plovdiv. SUBJECTS AND METHODS: Nuliparous women who at the period of the delivery were at 11-19 years old and were seen at the obstetric unit of the above hospital were recruited into the study. Observed complications during the pregnancy and delivery were also calculated. RESULTS: For the period of 10 years the teenage pregnancy rate was 8.22%/n= 958/ of all 11657 deliveries /91.78%/. 901 of the teenagers were aged 16 to 19 years /7.73%/ while only 57/0.49%/ were aged 11 to 15 years. In 69.42% /n= 665/ of the cases the deliveries were not complicated; in 30.58% of the cases there were complications or the delivery ended surgicaly. CONCLUSIONS: Pregnancy during teenage years remains major public health problem with lasting repercussions for the teenage mothers and their infants but also for their families and society as a whole. The prevention of the adolescent pregnancy by executing proven and effective programs would decrease its frequency and the complications associated with it.

Adolescent↗
PubMed2006

[The effect of contraceptive with 20 ug ethinylestradiol and 150 ug desogestrel on some acute phase proteins].

BACKGROUND: We present the influence of monophasic combined oral contraceptive with 20 mmicrog ethinylestradiol /150 microg desogestrel upon some acute phase proteins: C- reactive protein, fibrinogen, haptoglobin and the connection between the proinflammatory effect of oestrogens METHODS: Forty clinically healthy young women between 18 and 35 years, using oral contraceptives in the duration of 12 months, are included in this study. RESULTS: We don't find statistically significant differences in the plasma concentrations of C--reactive protein, fibrinogen, haptoglobin on the 12th month of the using of the oral contraceptives in comparision with the initial levels of the variables, before starting the study. CONCLUSION: The reduction of the dose of ethinylestradiol, definitely reduces the effects of oral contraceptives upon acute phase proteins and eventually the increased risk of cardiovascular disease.

Acute-Phase Proteins↗
PubMed2006

[Pregnancy outcomes in women of advanced maternal age].

UNLABELLED: During the last decade there is a trend all over the world women at advanced age/older than 35 years old/ and especially educated ones to postpone their reproductive plans. Pregnancy and birth outcomes in women >35 years old I traditionally associated with increasing risk of complications both for the mother and the foetus. OBJECTIVE: To study the frequency and the obstetric outcome of pregnancy at advanced age women in the University Hospital "St. George" Plovdiv. SUBJECTS AND METHODS: Women who at the period of the delivery were at more than 35 years old and were seen at the obstetric unit of the above hospital were recruited into the study. Observed complications during the pregnancy and delivery were also calculated. RESULTS: For the period of 10 years the teenage pregnancy rate was 5.10% /n= 594/5.10% of all 11657 deliveries /94.90%/. 504 of the patients were aged 35 to 39 years /4. 32%/ while only 90 /0.78%/ were aged > 40 years old. In 54.88% of the cases the deliveries were not complicated; in the rest of the cases there were complications or the delivery ended surgicaly. CONCLUSIONS: The increasing frequency of the advanced age pregnancy and deliveries and improved pre and intranatal counseling has made advanced maternal age compatible with successful pregnancy for the great majority of such women.

Adult↗
PubMed2006

[Obesity and pregnancy].

UNLABELLED: The increasing frequency of preobesity and obesity in all age groups worldwide can be characterized as a pandemia. Obesity is a public health problem because it is a major contributing factor in the development of hypertension, heart disease, type II diabetes, osteoarthritis, respiratory problems and certain cancer. THE OBJECTIVE OF THE STUDY: To describe the prevalence of preobesity and obesity among pregnant women and to evaluate the impact of preobesity and obesity upon pregnancy and delivery. SUBJECTS AND METHODS: 255 women, aged between 17 and 39 years old are conducted in the study. They have been admited to the Clinic of Obstetrics and Gynecology at the University Hospital "St. George" Plovdiv for the period of for months /January- April 2005/. The data of the patients are obtained from their history of the disease and the dokument of the newborn. BMI was calculated before and at the end of pregnancy. RESULTS: Preobesity and obesity are more frequent at more educated women, nuliparous women and women aged 30 years and more. Obese women had a higher frequency of preeclampsia, gestational diabetes, macrosomia, and operative delivery. 33.33% (n=85) of the pregnant women start their pregnancy with abnormal weight or obesity. At the end of the pregnancy 72.94% (n=186) of them are in condition of preobesity and obesity. CONCLUSION: As overweight and obesity are associate with adverse pregnancy outcomes, the attention of the obstetritian must be directed to so called preconceptual consulting in order to limit the gaining of wight upon the optimal limit before and during pregnancy.

Adolescent↗
PubMed2006

[Hyperlipidemic pancreatitis during pregnancy--a case report].

We present a case of acute pancreatitis during pregnancy, associated with hyperlipidemia. The patient, 23 years old in 36 g. w., was hospitalized at the Clinic of Obstetrics and Gynecology with nausea, multiple vomitting, persistent abdominal pain and febrility. Because of the clinical apperance of acute pancreatitis Ceaserean Section was performed with subsequent revision of the abdominal cavity, necrectomy of the pancreas, laparostoma, lavage, drainage, nutritional yienostoma. Intubation with artificial pulmonary ventilation and high volume continuous veno-venous haemofiltration (HV CVVH) was performed because of the development of polyorgan insufficiency and ARDS. After the procedure the patient condition became stable. After four months of hospitalisation, she was discharged from hospital with stable vital signs.

Female↗
PubMed2006

[C-reactive protein in women with pre-eclampsia].

UNLABELLED: Preeclampsia is a disorder associated with generalized dysfunction of endothelial cells probably as a result of systematic inflammatory maternal reaction. CRP is a positive marker of inflammation higher at overt preeclampsia than in normal pregnancy. The aim of the present study is to observe the variations of the acute phase protein CRP at women with preeclampsia and those with normal pregnancy in the third trimester. MATERIAL AND METHODS: Sixty women are included in the study, separated into two groups; group A (n = 30), consisted of women with overt preeclampsia and group B (n = 30)- women with normal pregnancy. Plasma levels of CRP are measured by using immunoturbidimetric method and the results are statistically calculated by variative analysis. RESULTS: We found statistically significant difference in plasma concentration of CRP between pregnant women with preeclampsia and those with normal pregnancy (t = 2.92, P < 0.01). CONCLUSION: In conclusion our data about the significantly higher values of CRP at women with preeclampsia are in agreement with the statement for presence of pronounced inflammation at preeclampsia compared with normal pregnancy.

Biomarkers↗
PubMed2006

[Effect of oral contraceptives on vaginal flora].

The contraceptive and non contraceptive advantages of oral chormonal contraceptives as well as the good control on fertility, make it one of the most preffered method of contraception. The normal vaginal flora is a dynamic ecosystem and itsequilibrium and status of eubyosis amongst its inhabitants is an important mechanism against exogenous infections. The use of oral contraceptives is not associated with significant changes in the vaginal microbial flora; the normal concentration of the lactobacillli is preserved.

Bacteria, Aerobic↗
PubMed2006

[Thrombophilia and pregnancy].

The incidence of venous thromboembolism is increased five to six times in pregnancy; and it is estimated that thromboembolic episodes- superficial and deep venous thromboembolism and pulmonary embolism occur in 1:1000 to 1:1500 pregnancies. These complications during pregnancy and puerperium, are not common but serious and leading cause of maternal morbidity and mortality. Thrombophilias--acquired or inherited, result of anticoagulant regulatory proteins deficiency, could compromise normal pregnancy by increasing the risk of developing first or recurrent thromboembolic incidents and adverse obstetric events.

Female↗
PubMed2005

[Mesenteric venous trombosis and pregnancy--a case report and a short review of the problem].

Mesenteric venous thrombosis is extremely rare surgical pathology during pregnancy and frequently is associated with hemoglobinopathies beta-thalassemia, congenital defects of the coagulation and antiphospholipide syndrome. It has nontypical clinical appearance, which hardens the timely diagnosis and the adequate surgical treatment. We present a case of a 22 year-old girl with hemozygote form of beta thalassemia, pregnant in ml II, with mesenteric venose thrombosis. The diagnosis was made on the 24th hour from the beginning of the disease. The patient was operated successfully by a resection of the necrotic changed part of the intestine. She noticed vaginal bleeding due to a missed abortion on the 22nd day after the operation.

Adult↗
PubMed2004

[Effect of low-dose oral contraceptive regulon-Gedeon Richter on some hemostatic variables].

The authors have investigated the changes of some haemostatic variables at 33 women, who used low-dosed oral contraceptive REGULON--Gedeon Richter in the duration of six months. Statistically significant decrease is found in the activity of Protein S and Protein C, but plasminogen level is increased. The levels of the other variables remained in referential ranges. The use of REGULON doesn't influence the coagulation system.

Adolescent↗
PubMed2004

[Effect of the monophase oral contraceptive combination with 20 ug ethinyl estradiol/150 ug desogestrel on haemostasis].

The authors examined the changes in the haemostasis during the use of the oral contraceptive combination with 20 microg ethynil estradiol/150 microg desogestrel at 35 women, a basic group, who used the oral contraceptive in the duration of 12 months and a control group (n=35), who do not use the pills. We found statistically significant increase of Antithrombin III (ATIII) (p<0.011), Cofactor II of Heparin (HCII) (p<0.001), the activity of plasminogen (p<0.026) and beta2-antiplasmin (0.026), significant decrease of Protein C (PrC) (p<0.0001) and of total Protein S (TPrS) (p<0.03) in the basic group in comparision with the control one. We do not observe significant changes in the rest of the haemostatic variables between the two groups. During the use of the oral contraceptive combination with 20 microg ethynil estradiol/150 microg desogestrel the changes in the system of the natural inhibitors are balanced by these in the system of fibrinolysis.

Adolescent↗
PubMed2004

[Postoperative nausea and vomiting--possibility to prevent after long-lasting gynecological operations].

The aim of this study is to establish the possibilities for effective influence upon the postoperative nausea and vomiting and to summarize the existing literature data. The observation is carried out upon 361 patients with performed hysterectomy, who were hospitalised at the Department of Obstetrics and Gynecology of the University Hospital "Saint George" Plovdiv for the period January-December 2003 year. We performed randomized study about the effect of the application of dexamethasone used in the introduction of anaesthesia and its effect upon the postoperative nausea and vomiting. Our observation confirms the literature data about the safe and effective application of dexamethasone as a method of choice for minimizing the frequency of the postoperative nausea and vomiting

Adult↗
PubMed2004

[Perforation of duodenal ulcer in the puerperium--a case report].

The authors present a case of perforated duodenal ulcer in the puerperium at a patient who underwent Ceaserian section. Urgently 12 hours after the perforation relaparotomy was made. The exit of the illness depends on the precise and early diagnosis and subsequent surgical treatment.

Adult↗
PubMed2004

[The effect of two low dose oral contraceptive with gestodene on the systems of natural inhibitors of coagulation].

AIM: The authors investigated the influence of two monophasic oral contraceptives with 30 and 20 microg ethynilestradiol (EE) with combination with 75 microg gestodene (GSD) upon the system of natural inhibitors of coagulation. MATERIALS AND METHODS: The study is prospective for a period of 12 months and was conducted upon 105 clinically healthy women, who use 30 microg EE/75 microg GSD (n = 35), 20 microg EE/75 microg GSD (n = 35) and a control group (n = 35). RESULTS: The continuous use of the contraceptive combination with 20 g EE/75 g GSD leads to statistically significant elevation of protein C (PrC), total protein S (TPrS) and Heparin Cofactor II (HCII). The use of the contraceptive combination with 30 microg EE/75 microg GSD is associated with statistically significant increase of Pr C and HC II. There were no statistically significant changes in the other variables. CONCLUSION: The use of both oral contraceptive combinations is associated with increased anticoagulant activity, which status prevents from thrombosis.

Adolescent↗
PubMed2004

[Acute pancreatitis and pregnancy--analysis of a 10 year period of time].

Acute pancreatitis during pregnancy is rare and complicates one in 1000 to 5000 pregnancies. The commonest reasons during pregnancy are: biliary disease, congenital or acquired hypertriglyceridemia and very rarely acute pancreatitis is associated with preeclampsia-eclampsia or HELLP syndrome. We presented in the research the clinical course of 14 women who developed acute pancreatitis and were treated at the Clinic of Thoraco-abdominal and Hepato-Biliary Surgery at the University Hospital Plovdiv for a tenth year of a period. The leading etiology was biliary disease. Eleven of 14 patient were successfully treated conservatively during pregnancy; 5 of them underwent surgery after pregnancy. Only one patient underwent operative treatment during pregnancy. Although acute pancreatitis is a rare disease during pregnancy, in order to improve the prognosis and to decrease the maternal and fetal morbidity and mortality, a timely diagnosis and an adequate conservative or surgical treatment is necessary.

Acute Disease↗
PubMed2003

[Peritoneal cyst--a case report].

Peritoneal cysts are rare benign tumors of the abdominal and pelvic peritoneum. We present a case of 26 year old patient with a peritoneal cyst treated operatively.

Adult↗
PubMed2003

[Clinical study of the low dose oral contraceptive novynette].

The authors review the efficacy, control of the menstrual cycle and the tolerance of the low-dosed oral contraceptive Novynette (20 mkg EE/150 desogestrel) of Gedeon Richter at 25 women, included in the study. The results show: Pearl index = 0.00, a good control over the menstrual cycle, not significant and transitor side effects.

Contraceptives, Oral, Combined↗