Biomedical subjects

E V Aksenova

Publications and source records attributed to E V Aksenova.

6 recordsLinked to original sources

PubMed2005

Scattering of light in cholesteric liquid crystals with large pitch.

We consider the problem of light scattering in a slab of cholesteric liquid crystal with the pitch which significantly exceeds the wavelength of light. The electromagnetic wave propagation and the Green's function are investigated for this medium basing on geometric optics approximation. The correlation function of the director fluctuations is calculated with the aid of the vector analog of the WKB approximation. A general approach to treatment of single light scattering in a stratified medium with smoothly varying properties based on the Kirchhoff method is developed. Angular and polarization dependencies of the single light scattering intensity as well as extinction of the mean field are analyzed. Unusual dependence of the light scattering intensity on the size of the system is found.

Journal Article↗

PubMed2004

[Expression of PRAME gene in multiple myeloma].

AIM: To determine clinical significance of PRAME gene expression in multiple myeloma (MM) and feasibility of its use as a marker of residual tumor clone. MATERIAL AND METHODS: 35 MM patients, of them 15 were newly diagnosed and 20 had resistance to previous therapy. PRAME was made if the patients received programmed therapy with high-dose chemotherapy (VD) and autologous transplantation of peripheral cell stem cells. 12 PRAME-positive patients were examined on the day +100, 5 patients--a year later. Monoclonal paraprotein was detected by electrophoresis and radial immunodiffusion of blood serum. Bone marrow affection was assessed at roentgenography and/or MRI. PRAME gene expression in bone marrow biopsy was measured by reverse transcription and PCR amplification. RESULTS: Activation of expression of PRAME gene in MM was found in 68.57% patients. It was higher in patients with MM duration more than 1 year and if they were treated before (85%) than in new cases (46.67%). Expression of PRAME tended to associate with activity of LDP of blood serum. After the above chemotherapy and autotransplantation transcript PRAME did not disappear in 8 of 12 cases. One year after the treatment, of 5 PRAME-positive patients 2 died, 1 had recurrence, 2 are in a compete clinicohematological remission. CONCLUSION: Frequent activation of transcription of the gene PRAME in MM, its assay can be used for monitoring of the disease course, assessment of remission completeness, detection of tumor cell contamination of preparations of autologous stem cells of peripheral blood.

Adult↗

PubMed2003

[Cytomegaloviral infection in patients with hemoblastoses].

AIM: To estimate the incidence of cytomegaloviral (CMV) infection and CMV disease in patients with acute leukemia at different stages of chemotherapy and in patients after transplantation of hemopoietic cells. MATERIAL AND METHODS: The trial was carried out in 33 patients with acute leukemia at different stages of chemotherapy, 20 patients subjected to transplantation of autologic hemopoietic cells and 21 patients who had received transplantation of allogenic hemopoietic cells. To study the dynamics of the CMV infection markers, enzyme immunoassay of the titer of the specific immunoglobulins M and G was made, detection of the viral antigen in immunofluorescence reaction and cultivation with fibroblast cell culture and determination of the cytomegalovirus DNA by polymerase chain reaction (PCR). RESULTS: Before chemotherapy, up to 90% patients with acute leukemia were infected with cytomegalovirus (similar rate of infection was observed in healthy donors of hemopoietic cells). By the time of transplantation all the patients were infected with cytomegalovirus. During chemotherapy of acute leukemia, the primary infection and reactivation of latent infection occurred in 30% patients, whereas CMV disease developed in 18% patients. In case of transplantation of autologic hemopoietic cells the rate of reactivation of CMV infection (15%) was one-half of that value in patients with acute leukemia (30%). Similar trend was observed in case of development of CMV disease (5% and 18%, respectively). In case of transplantation of allogenic hemopoietic cells the incidence of reactivation of CMV infection was three times higher than in case of transplantation of autologic hemopoietic cells (47.6% and 15%, respectively, p = 0.02). The incidence of development of CMV disease in case of transplantation of allogenic hemopoietic cells was also significantly higher than in case of transplantation of autologic hemopoietic cells (28.6% and 5%, respectively, p = 0.05). CONCLUSION: Cytomegalovirus is an infection agent responsible for severe complications of chemotherapy of acute leukemia and transplantation of hemopoietic cells in patients with hemoblastoses. Among hematological patients, the group of the highest risk of development of this complication includes recipients of transplantation of allogenic hemopoietic cells, particularly from seronegative donors.

Adolescent↗

PubMed2001

Multiple scattering temporal correlation function in a half space with finite-size heterogeneities.

An exact solution for the boundary problem of temporal correlations of light multiply scattered from a medium occupying a half space is found by means of the Wiener-Hopf method, taking into account single-scattering anisotropy. Within the P1 approximation a universal initial decay rate of the temporal correlation function is obtained. For larger time intervals a higher single-scattering anisotropy yields a higher decay rate contrary to predictions of the diffusion approximation. Within the P2 approximation, which takes account of the first- and second-order Legendre polynomials, the solution obtained becomes universal in an expanded temporal range and agrees rather well with the known measurement data.

Journal Article↗

PubMed1981

[Protective properties of antigenic complexes of Proteus].

To determine the possibility of the specific therapy and prevention of Proteus infection, the protective activity of antigenic complexes extracted from Pr. mirabilis cells by various methods was studied. Immunization of mice with these antigens rendered the animals resistant to challenge with a virulent Proteus strain, and the therapeutic injection of the antigens alleviated the infectious process developing as a result of intradermal infection. The blood sera of the treated rabbits acquired capacity of protecting mice from the Proteus infection.

Animals↗

PubMed1980

[Use of the edema test of the extremities in white mice for studying purulent Proteus infection].

The injection of non-enterotoxigenic Proteus strains into the paw pad of white mice caused paw edema, its intensity being proportional to the dose used for the test. The exudate consisted of granulocytes. Immunization with isolated Proteus antigens prevented the development of edema. This test is recommended as a model of local purulent infection. The optimal methods for the statistical analysis of the results thus obtained is proposed.

Animals↗