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Biomedical subjects

E V Dmitrichenko

Publications and source records attributed to E V Dmitrichenko.

10 recordsLinked to original sources
PubMed1993

[Cardiodynamics and myocardial contractile reserve in patients with hypertrophic cardiomyopathy].

Cardiodynamics and myocardial contractile reserve were studied in 60 patients with hypertrophic cardiomyopathy by using radionuclide ventriculography at rest and during graded exercise test. All findings that characterize cardiodynamics (normal or higher overall ejection fraction and stroke volume or lower end-systolic volume, higher maximum ejection rate) show the contractility of the left ventricle in patients with hypertrophic cardiomyopathy which can be regarded to be more severe. During graded exercise test, in patients with hypertrophic cardiomyopathy three types of reactions were identified: (1) positive inotropic effect; (2) negative inotropic effect; (3) intermediate (deviation of major cardiodynamic parameters was no more than 20-25% of the baseline levels). Identification of the above types allows one to assess the presence and conditions of myocardial contractile reserve implementation in these patients and to objectivize the choice of corrective drugs.

Adolescent↗
PubMed1992

[Diastolic filling of the left ventricle in relation to the degree of its hypertrophy in patients with ischemic heart disease].

The features of diastolic filling of the left ventricle (LV) were examined in relation to the nature of its hypertrophy in patients with coronary heart disease (CHD). A total of 110 male patients with CHD concurrent with essential hypertension or without it who underwent contrast ventriculography in order to determine LV diastolic stiffness. Radionuclide ventriculography was performed in 49 patients at rest and during exercise. The CHD patients with moderate LV concentric hypertrophy had more adequate LV diastolic filling in the presence of concurrent essential hypertension. Abnormal diastolic filling was more pronounced in CHD patients without hypertrophy or its eccentric development than in those without essential hypertension.

Adult↗
PubMed1991

[Radionuclide ventriculography in the diagnosis of hypertrophic cardiomyopathy].

Total and regional (by 7 zones) contractility of left ventricular functions in 25 patients with hypertrophic cardiomyopathy (HCMP) were characterized by a different combination of normal and elevated values of total and regional ejection fractions, rate indices of systolic expulsion. Normal or slightly changed values of the end-diastolic volume were combined with normal or elevated values of the stroke volume. Comparative analysis of the values characterizing cardiodynamics, led to working out criteria of differential diagnosis in HCMP patients with heart pain and in CHD patients with myocardial hypertrophy (predominance of the signs of left ventricular hyperfunction in the former and contractility hypofunction and asynergy in the latter). Changes in the diastolic filling of the left ventricle indicated its disturbed diastolic function in both groups of patients.

Adolescent↗
PubMed1990

[The functional assessment of left ventricular hypertrophy in patients with ischemic heart disease].

It was established that left ventricular hypertrophy in patients with ischemic heart disease associated with hypertensive disease reflects a functionally more intact myocardium than similar hypertrophy in analogous patients without hypertensive disease. Hypertrophy of the left ventricle in patients with ischemic heart of different severity may be considered an index of myocardial lesion and this should be considered in the treatment tactics.

Adult↗
PubMed1989

[The regional contractility of the left ventricle in patients with ischemic heart disease and concomitant hypertension].

Differential evaluation was carried out of hypertrophy as a factor possibly of compensatory or that of furthering disturbances of the coronary circulation and contractile function of the myocardium. Echocardiography, radionuclide ventriculography tests with physical loads revealed that only moderate hypertrophy of the left ventricle in IHD patients with hypertensive disease (grade II) may be considered as one of the compensatory factors maintaining the functional state of the left ventricle myocardium.

Cardiomegaly↗
PubMed1986

[Importance of collateral circulation for compensating for myocardial ischemia during physical loading in ischemic heart disease patients].

Exercise-induced electrocardiotopographic ST depression was analysed with reference to the presence of a collateral blood flow, angiographic assessment of the coronary bed and a history of myocardial infarction in 94 coronary patients. The presence of a collateral blood flow is shown to contribute to a more rapid elimination of post-exercise myocardial ischemia, irrespective of the number of affected coronary arteries and the history of myocardial infarction. Myocardial ischemia developing in response to exercise is particularly extensive in case of multiple coronary arterial lesions and the presence of a collateral blood flow.

Adaptation, Physiological↗
PubMedDate not supplied

[The ratio of the left ventricular systolic and diastolic functions in patients with hypertrophic cardiomyopathy].

A total of 60 patients with hypertrophic cardiomyopathy (HCMP) and 26 normal subjects were examined. HCMP patients showed increase in maximum ejection rate (ERmax) and shortening of time to reach it, which fact reflects augmentation of myocardial contractility in these patients. Significant alterations were also detectable in left ventricular diastolic function, manifested by a drop in maximum filling rate (FRmax), prolongation of time to reach it, diminution of filling fraction during phase of rapid filling, tendency toward increase of the filling fraction during diastasis phase and atrial systoles, reduction in indices of left ventricular volume compliance. The above alterations had a clear-cut association with the myocardial mass index. Comparative evaluation of left ventricular systolic and diastolic functions in HCMP patients indicated early and marked alterations in diastolic function of the left ventricle, preceding the development of systolic dysfunction, which fact is to be taken into account in choosing suitable medical treatment for HCMP patients.

Adolescent↗