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Biomedical subjects

E V Dubinina

Publications and source records attributed to E V Dubinina.

15 recordsLinked to original sources
PubMed1990

[Cardiovascular changes based on ECG data in workers involved in the elimination of the sequelae of the accident at the Chernobyl Atomic Electric Power Station].

122 persons who had participated in the Chernobyl nuclear power station disaster control were passed through ECG examinations, as a result of which susceptibility to bradycardia was revealed. To exclude a marked vagal influence on the myocardium, orthostatic, atropine and ephedrine tests were performed. Weakened reactions to atropine and ephedrine indicated a secondary vagotomy caused by the lowered sensitivity of beta-adrenoreceptors.

Accidents↗
PubMedDate not supplied

[The biodiversity dynamics of the causative agents of diseases transmitted by ticks in the genus Ixodes: an analysis of multiyear data].

Fauna of pathogen's met in the organism of the primary tick-borne disease vectors--Ixodes persulcatus Schulze and Ixodes ricinus (L.) was observed. Prevalence of Borrelia mono- and poly-infection in the I. persulcatus ticks within a season of the vector activity was analyzed and increase of the number of the dual infected specimens during the season was demonstrated. The first determination of Ehrlichia infected I. ricinus and I. persulcatus collected in the Baltic region of Russia was stated. The triple infection of Ixodes ticks in was proved: infection by the two species of Borrelia and Ehrlichia; infection by the three species of Borrelia and infection by the tick-borne encephalitis virus and two species of Borrelia. The first determination of the tick-borne encephalitis virus in I. ricinus in the recreational zone of Kaliningrad Province (Courland [correction of Curonian] Spit) was described. Dipetalonema sp. was detected in the St. Petersburg population of I. persulcatus. The prevalence of poly-infection among I. persulcatus ticks was stated.

Animals↗
PubMedDate not supplied

[Glycyphagus cadaverum housedust mites--a powerful source of allergens in Uzbekistan].

The house-dust mites, Glycyphagus cadaverum (Schrk.) and Dermatophagoides pteronyssinus (Trt.) are prevalent species in the houses of Uzbekistan. Their prevalence rates are 57.8 and 28.5%, respectively. G. cadaverum was detected in 62. 13% of the houses. It numbered as many as 1013 per g of dust. The tick, house dust and feeding media were extracted and allergic reactions to the extracts were examined by three immunological assays: passive hemagglutination test, indirect degranulation test, and common anaphylactic reaction: The study demonstrated that the extract from G. cadaverum had a higher allergenic potency, which is commonly used in Uzbekistan for the diagnosis of asthma.

Allergens↗
PubMedDate not supplied

[Detection of the genotypic heterogeneity of Ixodes persulcatus Schulze (Acari: Ixodidae) of the North-West region of Russia and characteristics of distribution of tick-borne pathogens causing Lyme disease and Ehrlichia infections in various genotypes].

The heterogeneity of the Ixodes persulcatus population in the vicinity of Saint Petersburg was estimated by using malate dehydrogenase (MDH) isoenzyme. There are six MDH genotypes carrying 3 alleles in the Ixodes persulcatus population. The prevalence of Borrelia and Ehrlichia species in the study genotypes was analyzed. There was a difference in the prevalence and intensity of infection. The greatest abundance of Borrelia was described in the genotypes to Genogroup 1 (with allele 1). Among them, heterozygous ticks were most intensively infected. Polymerase chain reaction identified species pathogenic for man. These included 3 species of Borrelia: B. afzelii, B. garinii, and B. burgdorferi sensu stricto and 2 species of Ehrlichia muris and HGE agent. The author are the first to describe HGE agent and B. burgdorfei ss encountered in Russia.

Animals↗
PubMedDate not supplied

[Borreliae as possible antagonists of tick-borne encephalitis virus: parasitologic and clinical aspects].

An attempt was made to compare the Borrelia-TBE-virus interface in Ixodes ticks and in patients. The authors suppose that Borrelia might suppress viral replication in ticks and in TBE-susceptible individuals. Whether antibiotics (particularly representatives of the tetracycline group) may be essential in treating tick-borne diseases is also discussed. Examples of antibiotic suppression of Borrelia that made the clinic presentation of encephalitis more severe as a consequence are analyzed and discussed. The calculated risk for borreliosis or tick-borne encephalitis and the actual morbidity rates were compared. Possible reasons for disagreement in the results are also discussed.

Adult↗
PubMedDate not supplied

[Possible types of tick-borne diseases and the predictive role of history data in their diagnosis (parasitological aspects of the problem)].

The paper discusses the proven and probable role of different tick-borne pathogens and their combinations in the occurrence of zoonotic diseases. The variants of coexistence of various combinations of 7 proved disease agents (3 species of Borrelia, 2 species of Ehrlichia, Babesia, and TBE virus) with different, if might to be, disease agents, such as rickettsiae of two groups, which do not belong to the Borrelia burgdorferi sensu lato group spirochetes, are analyzed. The difference of their development and the time of transmission after of the vector Ixodes persulcatus Schulze attachment are considered. Based on the their own hypothesis that one tick specimen is able to be the vector of only three human pathogenic agents simultaneously, the authors examined the possible number of combinations of pathogens, which might be obtained by a patient after 1 tick attachment. Proper history data are recommended as a tool for making a correct diagnosis, wherein the time of attachment has to be a main factor. For example, it should be taken into account that TBE virus might be transmitted only some minutes after attachment by not only a female tick, but also a male one. Mixed infection of virus plus Borrelia might develop only following some hours of attachment (most probably after 18-24 hours). The very similar situation has to be considered to lead to virus-Borrelia-Ehrlichia (or Rickettsia) coinfection. Any combination with Babesia involvement may appear not earlier than 24-36 hours after mixed infected tick attachment (or even later). It is necessary to consider a possible role of apathogenic microorganisms which are present in the most of vector specimens in nature and which might be injected with infected tick saliva may play a possible role in the manifestation of disease and in the prediction of their possible influence.

Animals↗
PubMedDate not supplied

[Fauna of dust-dwelling mites in the Maritime Territory].

The specific composition of acarid mites occurring in dust of rural dwellings in the Far East of the USSR has been first studied and characters of their fauna have been revealed. 3 species are most frequently encountered of which Dermatophagoides pteronyssinus accounts for 56% of all finds. 6 species happened to be new for the fauna of dwellings. The typical synanthropic species Glycyphagus domesticus is totally absent from dwellings but occurs in 90% of honey-bee hives.

Animals↗
PubMedDate not supplied

[An attempt at an economic assessment of the damage caused by allergenic house dust mites].

Mites have been found to contribute to the etiology of some allergic diseases most common in Uzbekistan. The economic losses caused by atopic dust-borne asthma have been estimated. The losses due to damage to the national income, which are done by disability and to the direct and indirect expenses on treatment and disability allowance have been calculated and compared. Such an attempt is useful to calculate the profitability of prevention of domestic dust mite-caused diseases and of the mite control measures.

Adolescent↗
PubMedDate not supplied

[The functioning of foci of mixed tick-borne infections on Russian territory].

Based on the studies of behavioral variations in ixodes persulcatus ticks under the influence of their carried pathogens, the authors forward a hypothesis for that there is antagonism between Borrelia and tick-borne encephalitis virus in the vector. Experiments demonstrated that Borrelia-infected ticks had a lower viral sensitivity than did noninfected ticks. There was inhibited viral reproduction in the ticks with double infection. Evidence is presented for that the Borrelia-infected nymphal ticks display the specific behavioral and viral susceptible features that are physiologically peculiar to older Borrelia-free individuals. It is concluded that the prevalence of Borrelia in the populations of ticks in the foci of mixed infections is associated with their property to suppress viral reproduction in the Borrelia-infected ticks.

Animals↗