PubMed Health⌕ Search

Biomedical subjects

E V Flerov

Publications and source records attributed to E V Flerov.

At least 19 recordsLinked to original sources
PubMed1995

[Effects of nitroglycerin on myocardial contraction in patients with ischemic heart disease].

The effects of nitroglycerin on central hemodynamics and direct myocardial contractility were directly studied in 32 patients with functional class III-IV heart failure during aortocoronary bypass surgery. When nitroglycerin was used, hemodynamic parameters changed in two stages: 1) systemic blood pressure initially slightly increased; 2) decreases in this and other central hemodynamic parameters occurred. The dynamics of myocardial function was determined by its baseline state, dyskinetic intensity, i.e. its contractility. In patients with preserved myocardial function, nitroglycerin failed to cause its substantial dysfunction. At the same time its contractility and central hemodynamic parameters might considerably deteriorate in patients with moderate dyskinesia and furthermore with severe myocardial dysfunction.

Adult↗
PubMed1990

[Disorders of the oxygenating function of the lungs during open-heart surgery].

A retrospective analysis of arterial blood oxygenation during open-heart surgery in 463 patients revealed pulmonary oxygenation disorders in 23% prior to perfusion and in 49% in the post-perfusion period. The basic mechanism underlying the fall in arterial blood oxygenation is the increasing venous admixture in the lungs. A growth in the venous admixture in the post-perfusion period is brought about by a decreased total ventilation/perfusion ratio, increased alveolar shunting, and impaired diffusion. It was found, that the assisted ventilation regimen at +5+8 cm H2O in the post-perfusion period caused a 30% reduction in the venous admixture and improved the blood oxygenation. Additional use of diuretics to diminish the intrapulmonary water causes a 59% reduction in the venous admixture. A prophylactic pre-perfusion administration of corticosteroids, vitamin E, and protease inhibitors maintains the oxygenating function of the lungs, which is manifested in a higher blood oxygenation in these patients after assisted circulation compared to the controls.

Adrenal Cortex Hormones↗
PubMed1985

[Use of a multifunctional catheter for assessing cardiovascular function].

A new method of cardiovascular investigation with a multifunctional catheter was used in 56 cardiac and pulmonary patients. The multifunctional catheter enabled simultaneous measurement of the intravascular pressure and liner flow rate in large vessels (both arteries and veins). Prospects are outlined for the multifunctional catheter to be used for continuous hemodynamic monitoring, and developing, on this basis, of a computer monitoring system to assess cardiac performance during surgery.

Adult↗
PubMed1984

[Effect of isosorbide dinitrate (isoket) on central hemodynamics and myocardial contraction in patients with ischemic heart disease].

The authors studied the effect of isoket on the central hemodynamics and myocardial contractility as well as on the conditions of myocardial functioning in 38 patients aged 28-53 years and suffering from coronary heart disease. The infusion of 2 mg of isoket at a rate of 400 micrograms/min was followed by a decrease in the arterial pressure with the maximum drop seen on the seventh minute (by 26% from the baseline value), a reduction in the end-diastolic pressure by 50%, and a lengthening of the preejection period without any significant changes in either the cardiac output or the total peripheral resistance. Taken as a whole these changes justify the conclusion that the influence of dinitrate isosorbite (isoket) on the central hemodynamics is largely due to its venodilating action leading to a reduction of the pre-load which in turn improves myocardial functioning.

Adult↗
PubMed1977

[Effect of prostaglandin Bl on systemic and regional hemodynamics].

The effect of prostaglanding B1 (PGB1) on the cardiovascular system of dogs was studied in experiments on anesthetized dogs. The intravenous injection of PGB1 (40 microng/kg) was followed by aortic hypertension, tachycardia, an increase of myocardial contractility, an enhancement of minute volume of the heart, and in increase of arterial pressure in the pulmonary artery. Total peripheral resistance and total lung resistance were reduced. The work of the left and the right ventricles and the coronary flow increased (the latter by 29%). The average voluminous blood flow velocity in the femoral and the superior mesenteric arteries increased significantly, while in the common carotid and the renal arteries--insignificantly. The observed changes in the systemic and regional hemodynamics were of short duration.

Animals↗
PubMed1977

[Effect of prostaglandin E1 on the systemic and regional hemodynamics of dogs].

The effect of prostaglandin E1 (PGE1) on the cardiovascular system of the dog has been studied in experiments with anesthetized dogs. After intravenous injections of PGE1 (5 microgram/kg) arterial hypotension, tachycardia, increase of cardiac output, increase of myocardial contractility were observed. PGE1 induced dilatation of pulmonary vessels. Peripheral resistance reduced. The work of the left ventricle after PGE1 injection underwent two-phase changes: it increased for a short period of time and then reduced. The work of the right ventricle was activated. PGE1 caused a significant increase of the volume flow rate in the coronary (44%), femoral (83%) and superior mesenteric (59%) arteries.

Animals↗